2020年4月15日
Behçet's Disease with Severe Autonomic Disorders Developing after Herpes Zoster.
Internal medicine (Tokyo, Japan)
- 巻
- 59
- 号
- 8
- 開始ページ
- 1099
- 終了ページ
- 1104
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2169/internalmedicine.3954-19
A 58-year-old Japanese woman with herpes zoster developed Behçet's disease (BD) with symptoms including orthostatic intolerance as an autonomic disorder. Multiple immune-suppressive therapies and a β-blocker successfully controlled both the disease activity of BD and the autonomic disorders. A cytokine multiplex analysis of her serum revealed the elevation of proinflammatory cytokines [interleukin (IL)-1, IL-6, IL-12, tumor necrosis factor alfa (TNFα), and interferon gamma (IFN-γ)] and a low IL-10 concentration. IL-10 production is reported to be important for defense against herpes zoster virus (VZV). Insufficient IL-10 production is reported in BD. The reactivation of VZV with this cytokine profile suggests that BD will develop with various symptoms, including severe autonomic disorders.
- リンク情報
- ID情報
-
- DOI : 10.2169/internalmedicine.3954-19
- PubMed ID : 32009095
- PubMed Central 記事ID : PMC7205542