Jan, 2014
Palladium-Catalyzed Regio- and Stereoselective Chlorothiolation of Terminal Alkynes with Sulfenyl Chlorides
CHEMISTRY-AN ASIAN JOURNAL
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- Volume
- 9
- Number
- 1
- First page
- 58
- Last page
- 62
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1002/asia.201301295
- Publisher
- WILEY-V C H VERLAG GMBH
Chlorothiolation of terminal alkynes with sulfenyl chlorides yields anti-adducts without transition-metal catalysts. In sharp contrast, transition-metal-catalyzed chlorothiolation has not been developed to date, possibly because organosulfur compounds can poison catalyst. Herein, the regio- and stereoselective palladium-catalyzed chlorothiolation of terminal alkynes with sulfenyl chlorides is described. syn-Chlorothiolation offers a complementary synthetic route to chloroalkenyl sulfides. 2-Chloroalkenyl sulfides can easily be transformed into various sulfur-containing products, most of which are often found in natural products and pharmaceuticals.
- Link information
- ID information
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- DOI : 10.1002/asia.201301295
- ISSN : 1861-4728
- eISSN : 1861-471X
- Web of Science ID : WOS:000328501400005