Masahiro Nagata - Papers

A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses.

Masahiro Nagata, Yasmin Carvalho Schäfer, Laurens Wachsmuth, Manolis Pasparakis

The EMBO journal, Sep 19, 2024

ADAR1 averts fatal type I interferon induction by ZBP1.

Huipeng Jiao, Laurens Wachsmuth, Simone Wolf, Juliane Lohmann, Masahiro Nagata, Göksu Gökberk Kaya, Nikos Oikonomou, Vangelis Kondylis, Manuel Rogg, Martin Diebold …

Nature, 607(7920) 776-783, Jul, 2022

Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors.

Masahiro Nagata, Kenji Toyonaga, Eri Ishikawa, Shojiro Haji, Nobuyuki Okahashi, Masatomo Takahashi, Yoshihiro Izumi, Akihiro Imamura, Koichi Takato, Hideharu Ishida …

The Journal of experimental medicine, 218(1), Jan 4, 2021

Design of potent Mincle signalling agonists based on an alkyl β-glucoside template.

Dylan G M Smith, Yuki Hosono, Masahiro Nagata, Sho Yamasaki, Spencer J Williams

Chemical communications (Cambridge, England), 56(31) 4292-4295, Apr 21, 2020

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation.

Lucie Laurien, Masahiro Nagata, Hannah Schünke, Tom Delanghe, Janica L Wiederstein, Snehlata Kumari, Robin Schwarzer, Teresa Corona, Marcus Krüger, Mathieu J M Bertrand …

Nature communications, 11(1) 1747-1747, Apr 8, 2020

High affinity sugar ligands of C-type lectin receptor langerin.

Fumi Ota, Tetsuya Hirayama, Yasuhiko Kizuka, Yoshiki Yamaguchi, Reiko Fujinawa, Masahiro Nagata, Hendra S Ismanto, Bernd Lepenies, Jonas Aretz, Christoph Rademacher …

Biochimica et biophysica acta. General subjects, 1862(7) 1592-1601, Jul, 2018

Mincle: 20 years of a versatile sensor of insults.

Xiuyuan Lu, Masahiro Nagata, Sho Yamasaki

International immunology, 30(6) 233-239, May 24, 2018

Lipidated Brartemicin Analogues Are Potent Th1-Stimulating Vaccine Adjuvants.

Amy J Foster, Masahiro Nagata, Xiuyuan Lu, Amy T Lynch, Zakaria Omahdi, Eri Ishikawa, Sho Yamasaki, Mattie S M Timmer, Bridget L Stocker

Journal of medicinal chemistry, 61(3) 1045-1060, Feb 8, 2018

Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity.

Masahiro Nagata, Yoshihiro Izumi, Eri Ishikawa, Ryoko Kiyotake, Rieko Doi, Satoru Iwai, Zakaria Omahdi, Toshiyuki Yamaji, Tomofumi Miyamoto, Takeshi Bamba …

Proceedings of the National Academy of Sciences of the United States of America, 114(16) E3285-E3294, Apr 18, 2017

Lipid structure influences the ability of glucose monocorynomycolate to signal through Mincle.

Phillip L van der Peet, Masahiro Nagata, Sayali Shah, Jonathan M White, Sho Yamasaki, Spencer J Williams

Organic & biomolecular chemistry, 14(39) 9267-9277, Oct 4, 2016

Total synthesis of a cyclopropane-fatty acid α-glucosyl diglyceride from Lactobacillus plantarum and identification of its ability to signal through Mincle.

Sayali Shah, Masahiro Nagata, Sho Yamasaki, Spencer J Williams

Chemical communications (Cambridge, England), 52(72) 10902-5, Sep 18, 2016

Pathogen-sensing by mincle: Function and molecular aspects

Masahiro Nagata, Zakaria Omahdi, Sho Yamasaki

C-Type Lectin Receptors in Immunity, 15-34, Jan 1, 2016 Peer-reviewed

Macrophage-inducible C-type lectin Mincle-expressing dendritic cells contribute to control of splenic Mycobacterium bovis BCG infection in mice.

Friederike Behler, Regina Maus, Jennifer Bohling, Sarah Knippenberg, Gabriele Kirchhof, Masahiro Nagata, Danny Jonigk, Nicole Izykowski, Lavinia Mägel, Tobias Welte …

Infection and immunity, 83(1) 184-96, Jan, 2015