Naoki Suzuki
(鈴木 直輝)
Modified on: 04/16
Profile Information
- Affiliation
- Department of Neurology, Tohoku University
- Degree
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MD, PhD(Mar, 2007, Tohoku University)
- J-GLOBAL ID
- 200901015923185416
- researchmap Member ID
- 5000066620
- External link
2001年に医師になって以降、脳神経内科臨床医として診療に携わる一方、筋萎縮性側索硬化症(ALS)と封入体筋炎やdysferlin異常症、GNEミオパチーなどの難治性筋疾患を主なターゲットに、iPS細胞・遺伝子解析・オミックス解析・動物モデル・神経筋病理などの各種手法を駆使し、一貫して神経筋疾患の病態・治療研究を続けています。特に運動ニューロン軸索の100年機能し続ける耐久性(レジリエンス)や常にメカニカルストレスにさらされている骨格筋の細胞膜修復・不要蛋白除去の分子機構を明らかにしたいと考えています。熱いパッションを持ちつつサイエンスを極め、臨床に還元することを目指しています。「難病や障害の克服とそれに向き合う人と社会のためにできることを」頑張ります。
Research Interests
20Research Areas
6Research History
8-
Oct, 2020 - Mar, 2024
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Oct, 2019 - Sep, 2020
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2015 - Sep, 2019
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Nov, 2011 - Sep, 2014
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Apr, 2007 - Oct, 2011
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Apr, 2004 - Mar, 2007
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Apr, 2003 - Mar, 2007
Education
3-
Apr, 2003 - Mar, 2007
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Apr, 1995 - Mar, 2001
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Apr, 1992 - Mar, 1995
Awards
13-
2020
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2016
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2011
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2011
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2010
Major Papers
192-
Annals of Clinical and Translational Neurology, Jan 29, 2024
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Annals of clinical and translational neurology, 11(3) 577-592, Dec 29, 2023
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Journal of neurology, neurosurgery, and psychiatry, 94(10) 816-824, Oct, 2023
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Orphanet Journal of Rare Diseases, 18(1) 241-241, Aug 11, 2023
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Nature aging, 3(8) 1001-1019, Jul 20, 2023
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Journal of Neurology, Neurosurgery & Psychiatry, 94(12) 1018-1024, Jul 14, 2023
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Cell stem cell, 30(6) 766-780, Jun 1, 2023
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Journal of neuromuscular diseases, 10(4) 555-566, Apr 25, 2023
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NEUROLOGY AND CLINICAL NEUROSCIENCE, 10(5) 239-244, Sep, 2022
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Scientific reports, 12(1) 14291-14291, Aug 22, 2022
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Journal of human genetics, Jun 13, 2022
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BMC neurology, 22(1) 94-94, Mar 16, 2022
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Scientific reports, 12(1) 1082-1082, Jan 20, 2022
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Stem cell reports, 16(6) 1527-1541, Jun 8, 2021
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Neurology, 96(12) e1595-e1607, Mar 23, 2021
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Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 81 92-94, Nov, 2020
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Communications biology, 3(1) 526-526, Sep 23, 2020 Peer-reviewed
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iScience, 23(9) 101491-101491, Aug 21, 2020 Peer-reviewed
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Brain : a journal of neurology, 143(8) 2398-2405, Aug 1, 2020 Peer-reviewed
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Human mutation, 41(9) 1540-1554, May 12, 2020 Peer-reviewed
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Molecular therapy : the journal of the American Society of Gene Therapy, 28(4) 1133-1153, Apr 8, 2020 Peer-reviewed
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Journal of neurology, neurosurgery, and psychiatry, 91(3) 285-290, Mar, 2020 Peer-reviewed
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PloS one, 15(12) e0231064, 2020
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Inducible Rpt3, a Proteasome Component, Knockout in Adult Skeletal Muscle Results in Muscle Atrophy.Frontiers in cell and developmental biology, 8 859-859, 2020 Peer-reviewed
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Frontiers in neuroscience, 14 194-194, 2020 Peer-reviewed
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HUMAN MOLECULAR GENETICS, 28(20) 3486-3497, Oct, 2019 Peer-reviewed
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The Lancet. Neurology, 18(9) 834-844, Sep, 2019 Peer-reviewed
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Scientific reports, 9(1) 11914-11914, Aug 15, 2019 Peer-reviewed
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EBioMedicine, 45 362-378, Jul, 2019 Peer-reviewed
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Orphanet journal of rare diseases, 14(1) 155-155, Jun 26, 2019 Peer-reviewed
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Stem cell reports, 11(6) 1523-1538, Dec 11, 2018 Peer-reviewed
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Translational Medicine Communications, 3(1), Dec, 2018 Lead author
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Journal of neuroscience research, 96(2) 222-233, Feb, 2018 Peer-reviewed
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Neurobiology of aging, 53 194.e1-194.e8-194.e8, May, 2017 Peer-reviewed
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Annals of neurology, 81(4) 512-525, Apr, 2017 Peer-reviewed
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Nature communications, 7 13283-13283, Oct 31, 2016 Peer-reviewed
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Science translational medicine, 8(347) 347ra93, Jul 13, 2016 Peer-reviewed
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Human molecular genetics, 25(9) 1814-23, May 1, 2016 Peer-reviewed
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Stem cell reports, 6(4) 496-510, Apr 12, 2016 Peer-reviewed
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Neurology. Genetics, 1(4) e36, Dec, 2015 Peer-reviewed
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NEUROLOGY-GENETICS, 1(3), Oct, 2015 Peer-reviewed
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Journal of human genetics, 60(10) 653-4, Oct, 2015 Peer-reviewed
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Neurology. Genetics, 1(3) e23-S280, Oct, 2015 Peer-reviewed
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Journal of cell science, 127(Pt 24) 5204-17, Dec 15, 2014 Peer-reviewed
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Neuromuscular disorders : NMD, 24(12) 1068-72, Dec, 2014 Peer-reviewed
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Science translational medicine, 6(248) 248ra104, Aug 6, 2014 Peer-reviewed
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Nature neuroscience, 16(12) 1725-7, Dec, 2013 Peer-reviewed
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Journal of human genetics, 58(5) 259-66, May, 2013 Peer-reviewed
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Journal of neurology, neurosurgery, and psychiatry, 84(4) 433-40, Apr, 2013 Peer-reviewed
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Journal of neuropathology and experimental neurology, 71(9) 779-88, Sep, 2012 Peer-reviewed
Misc.
336-
臨床神経生理学, 50(5) 400-400, Oct, 2022
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臨床免疫・アレルギー科, 78(4) 430-437, Oct, 2022
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脳循環代謝, 34(1) 142-142, Oct, 2022
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日本筋学会学術集会プログラム・抄録集, 8回 24-24, Aug, 2022
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日本筋学会学術集会プログラム・抄録集, 8回 144-144, Aug, 2022
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臨床神経学, 62(5) 409-409, May, 2022
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体力科学, 71(1) 55-55, Feb, 2022
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脳循環代謝(Web), 34(1), 2022
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臨床神経学, 62(1) 55-55, Jan, 2022
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筋ジストロフィー医療研究, 8 41-41, Nov, 2021
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BIO Clinica, 36(9) 838-842, Aug, 2021
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臨床神経学, 61(7) 509-509, Jul, 2021
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脳循環代謝(Web), 33(1), 2021
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多系統蛋白質症(MSP)患者の全国実態調査と診療体制構築に関する研究 令和2年度 総括・分担研究報告書(Web), 2021
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神経治療学(Web), 38(6), 2021
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筋ジストロフィー医療研究, 7 65-65, Jan, 2021
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日本筋学会学術集会プログラム・抄録集, 6回 124-124, Dec, 2020
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臨床神経学, 60(Suppl.) S55-S55, Nov, 2020
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臨床神経学, 60(Suppl.) S90-S90, Nov, 2020
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臨床神経学, 60(Suppl.) S128-S128, Nov, 2020
Books and Other Publications
8-
2024
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Springer Nature Singapore Ltd, 2017
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2015
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2013
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2013
Presentations
27-
遺伝子診療部教育セミナー2023, Nov 21, 2023
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第9回日本筋学会学術集会, Aug 18, 2023
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The 46th Annual Meeting of the Japan Neuroscience Society, Aug 1, 2023
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64th Annual Meeting of the Japanese Society of Neurology, Jun 2, 2023
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64th Annual Meeting of the Japanese Society of Neurology, Jun 1, 2023
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日本筋学会, Aug 5, 2022 Invited
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Neuro2022, Jun 30, 2022 Invited
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第76回日本体力医学会大会, Sep 17, 2021 Invited
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東海大学卓越研究員シンポジウム 「ヒト多能性幹細胞と多層的トランスレーショナル研究」, Dec 7, 2020 Invited
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電気化学会東北支部 第33回東北若手の会, Dec 5, 2020 Invited
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第61回日本神経学会, Aug 31, 2020 Invited
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メタルバイオサイエンス2018, Nov 16, 2018 Invited
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59th Annual Meeting of the Japanese Society of Neurology, May 26, 2018
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第35回日本神経治療学会, Nov, 2017 Invited
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第3回 日本筋学会, Aug, 2017 Invited
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第69回日本細胞生物学会大会, Jun, 2017 Invited
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21th World Muscle Society, Oct, 2016
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13th International Congress of Human Genetics, Apr, 2016
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rd World Centenarian Intiative International Symposium, 2016
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12th International Society for Stem Cell Research Modeling, Jun, 2014
Research Projects
20-
Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
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Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2023 - Mar, 2025
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Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
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科学研究費助成事業 基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024
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科学研究費助成事業 基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2023
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Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2022
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Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021
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Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021
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科学研究費補助金(基盤研究(C)), 文部科学省, Apr, 2018 - Mar, 2021
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Grants-in-Aid for Scientific Research Challenging Research (Exploratory), Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2020
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Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019
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希少難治性疾患に対する画期的な医薬品医療機器等の実用化に関する研究([新規化合物等治験](ステップ2)), 日本医療研究開発機構 AMED, 2018 - 2019
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Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018
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Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A), Grant-in-Aid for Young Scientists (A), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018
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Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016
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Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016
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疾患特異的iPS細胞を用いた難治性疾患の病態解明及び治療法開発に関する研究, 日本医療研究開発機構 AMED, 2015 - 2016
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科学研究費助成事業 若手研究(B), 若手研究(B), 日本学術振興会, 2010 - 2011
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Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2010 - 2011
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Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (Start-up), Grant-in-Aid for Young Scientists (Start-up), Japan Society for the Promotion of Science, 2007 - 2008