論文

国際誌
2017年8月

Curcumin reduces the risk of chronic kidney damage in mice with nonalcoholic steatohepatitis by modulating endoplasmic reticulum stress and MAPK signaling.

International immunopharmacology
  • Mst Rejina Afrin
  • Somasundaram Arumugam
  • Md Azizur Rahman
  • Vengadeshprabhu Karuppagounder
  • Meilei Harima
  • Hiroshi Suzuki
  • Shizuka Miyashita
  • Kenji Suzuki
  • Kazuyuki Ueno
  • Hiroyuki Yoneyama
  • Kenichi Watanabe
  • 全て表示

49
開始ページ
161
終了ページ
167
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.intimp.2017.05.035

Developing confirmation recommends that in patients with dynamic type of NAFLD, particularly nonalcoholic steatohepatitis (NASH) may have the pathogenic parts in the advancement of kidney damage. In this study we have examined the impact of curcumin on NASH instigated chronic kidney damage (CKD) and the putative mechanisms. To prepare this NASH model, neonatal C57BL/6J male mice were exposed to low-dose streptozotocin (STZ) and were fed high-fat diet (HFD) at the age of 4weeks and continued up to 14weeks, curcumin was given at 100mg/kg dose by oral gavage daily after 10weeks of STZ injection and continued for 4weeks along with HFD feeding. NASH incited mice demonstrated nephrotoxicity as proved by declining renal capacity, which was evaluated by measuring blood urea nitrogen and creatinine in serum and histopathological variations from the norm. These progressions were switched by curcumin treatment, which brought about huge change in renal capacity. Furthermore, curcumin markedly decreased NAD(P)H oxidase subunits (p67phox, p47phox, p22phox), nitrotyrosine and CYP2E1 renal protein expression as well as reduced pro-inflammatory cytokine expression (TNFα, IL-1β, IFNγ). Renal protein expression of mitogen activated protein kinases (MAPKs) (p-JNK, p-ERK1/2) and glucose regulated protein 78, CHOP were increased in NASH induced mice and curcumin treatment attenuated these increased expressions. In addition, curcumin treatment also decreased the apoptosis signaling proteins (cleaved caspase-3, cleaved caspase-12) in the NASH kidney. Taken together, our results suggest that curcumin preserves the renal function, probably by attenuating the ER stress mediated MAPK signaling.

リンク情報
DOI
https://doi.org/10.1016/j.intimp.2017.05.035
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28595079
ID情報
  • DOI : 10.1016/j.intimp.2017.05.035
  • PubMed ID : 28595079

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