論文

査読有り 国際誌
2013年8月1日

Dendritic cells regulate high-speed interstitial T cell migration in the lymph node via LFA-1/ICAM-1.

Journal of immunology (Baltimore, Md. : 1950)
  • Tomoya Katakai
  • ,
  • Katsuyoshi Habiro
  • ,
  • Tatsuo Kinashi

191
3
開始ページ
1188
終了ページ
99
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.4049/jimmunol.1300739
出版者・発行元
AMER ASSOC IMMUNOLOGISTS

T lymphocytes vigorously migrate within the paracortex of lymph nodes (LNs) in search of cognate Ags that are presented by dendritic cells (DCs). However, the mechanisms that support T cells to exert the highest motility in a densely packed LN microenvironment are not fully understood. Two-photon microscopy using LN tissue slices revealed that LFA-1 and ICAM-1 were required for high-velocity migration (>10 μm/min) with relatively straight movement. Importantly, ICAM-1 expressed by myeloid lineages, most likely DCs, but not stromal cells or lymphocytes, was sufficient to support the high-velocity migration. Visualizing DCs in the LN from CD11c-EYFP mice showed that T cells traveled over thin dendrites and the body of DCs. Interestingly, DCs supported T cell motility in vitro in chemokine- and ICAM-1-dependent manners. Moreover, an acute lymphopenic environment in the LN significantly increased LFA-1 dependency for T cell migration, indicating that lymphocyte density modulates the use of LFA-1. Therefore, our results indicate that LFA-1/ICAM-1-dependent interactions between T cells and DCs play a crucial role not only in supporting firm arrest during Ag recognition but also in facilitating the Ag scanning processes.

リンク情報
DOI
https://doi.org/10.4049/jimmunol.1300739
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23817428
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000322010100025&DestApp=WOS_CPL
ID情報
  • DOI : 10.4049/jimmunol.1300739
  • ISSN : 0022-1767
  • PubMed ID : 23817428
  • Web of Science ID : WOS:000322010100025

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