This paper proposes an optimum design method, based on our level set-based topology optimization method, for maximizing thermal diffusivity in problems dealing with generic heat transfer boundaries that include design-dependent boundary conditions. First, a topology optimization method using a level set model incorporating a fictitious interface energy for regularizing the topology optimization is briefly discussed. Next, an optimization method for maximizing thermal diffusivity is formulated based on the concept of total potential energy. An optimization algorithm that uses the finite element method when solving the equilibrium equation and updating the level set function is then constructed. Finally, several numerical examples are provided to confirm the utility and validity of the proposed topology optimization method. [DOI: 10.1115/1.4003684]