2011 - 2012
The effect of Treg-Th17 conversion induced by periodontopathicbacteria on osteoclastogenesis.
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B) Grant-in-Aid for Young Scientists (B)
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- Grant number
- 23792469
- Japan Grant Number (JGN)
- JP23792469
- Grant amount
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- (Total)
- 4,160,000 Japanese Yen
- (Direct funding)
- 3,200,000 Japanese Yen
- (Indirect funding)
- 960,000 Japanese Yen
We investigated whether the Treg-Th17 conversion is associated with the pathogenesis of periodontitis. Immunohistological analysis showed that IL-17A+FOXP3+ cells were observed only in periodontitis lesions but not in clinically healthy sites. Next, we established CD4+ T-cell lines from gingival tissues and peripheral blood of periodontitis patients. The proportion of IL-17+FOXP3+ cells in total FOXP3+ cellswas higher in gingival tissue CD4+ T-cell lines compared with peripheral blood CD4+T-cell lines.
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- ID information
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- Grant number : 23792469
- Japan Grant Number (JGN) : JP23792469