Noriko Miyake

Profile Information

Affiliation: Nippon Medical School

Degree: 医学博士

Researcher number: 00421206
J-GLOBAL ID: 201801016630196886
researchmap Member ID: B000317431

Committee Memberships

2022 - Present

日本遺伝子細胞治療学会評議員

Awards

Jul, 2015

Award for the Annual Meeting of JSGT, Trans-BBB gene therapy for metachromatic leukodystrophy using self-complementary type 9, Japan Society of Gene and Cell Therapy

Noriko Miyake
Oct, 2012

鈴木邦彦研究奨励賞, 日本ライソゾーム病研究会

三宅紀子

Papers

"A New Method for In Vivo Targeted Gene Transfer into Oligodendrocytes using Adenoviral and HIV Vectors"

Miyake K, Miyake N, Shimada T

Biomedical Journal of Scientific & Technical Research, 39(3), Oct 20, 2021 Peer-reviewed
Treatment of adult metachromatic leukodystrophy model mice using intrathecal administration of type 9 AAV vector encoding arylsulfatase A.

Noriko Miyake, Koichi Miyake, Atsushi Sakai, Motoko Yamamoto, Hidenori Suzuki, Takashi Shimada

Scientific reports, 11(1) 20513-20513, Oct 15, 2021
Treatment with bone maturation and average lifespan of HPP model mice by AAV8-mediated neonatal gene therapy via single muscle injection.

Tae Matsumoto, Koichi Miyake, Noriko Miyake, Osamu Iijima, Kumi Adachi, Sonoko Narisawa, José Luis Millán, Hideo Orimo, Takashi Shimada

Molecular therapy. Methods & clinical development, 22 330-337, Sep 10, 2021
Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration.

Hirofumi Yamaguchi, Shinya Honda, Satoru Torii, Kimiko Shimizu, Kaoru Katoh, Koichi Miyake, Noriko Miyake, Nobuhiro Fujikake, Hajime Tajima Sakurai, Satoko Arakawa …

Nature communications, 11(1) 5311-5311, Oct 20, 2020
TERT and TERC mutations detected in cryptic dyskeratosis congenita suppress telomerase activity.

Kazuki Terada, Koichi Miyake, Hiroki Yamaguchi, Noriko Miyake, Keiichiro Yamanaka, Seiji Kojima, Etsuro Ito, Koiti Inokuchi, Takashi Okada

International journal of laboratory hematology, 42(3) 316-321, Jun, 2020 Peer-reviewed
Tbx6 induces cardiomyocyte proliferation in postnatal and adult mouse hearts.

Haginiwa, Sho, Sadahiro, Taketaro, Kojima, Hidenori, Isomi, Mari, Tamura, Fumiya, Kurotsu, Shota, Tani, Hidenori, Muraoka, Naoto, Miyake, Noriko, Miyake, Koichi …

Biochemical and biophysical research communications, 513(4) 1041-1047, Jun, 2019 Peer-reviewed
D816V mutation in the KIT gene activation loop has greater cell-proliferative and anti-apoptotic ability than N822K mutation in core-binding factor acute myeloid leukemia

Ikuko Omori, Hiroki Yamaguchi, Koichi Miyake, Noriko Miyake, Tomoaki Kitano, Koiti Inokuchi

EXPERIMENTAL HEMATOLOGY, 52 56-64, Aug, 2017 Peer-reviewed
MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain

Atsushi Sakai, Fumihito Saitow, Motoyo Maruyama, Noriko Miyake, Koichi Miyake, Takashi Shimada, Takashi Okada, Hidenori Suzuki

NATURE COMMUNICATIONS, 8 16079, Jul, 2017 Peer-reviewed
miR-15b mediates oxaliplatin-induced chronic neuropathic pain through BACE1 down regulation

Naomi Ito, Atsushi Sakai, Noriko Miyake, Motoyo Maruyama, Hirotoshi Iwasaki, Koichi Miyake, Takashi Okada, Atsuhiro Sakamoto, Hidenori Suzuki

BRITISH JOURNAL OF PHARMACOLOGY, 174(5) 386-395, Mar, 2017 Peer-reviewed
Improved Intravitreal AAV-Mediated Inner Retinal Gene Transduction after Surgical Internal Limiting Membrane Peeling in Cynomolgus Monkeys

Kazuhisa Takahashi, Tsutomu Igarashi, Koichi Miyake, Maika Kobayashi, Chiemi Yaguchi, Osamu Iijima, Yoshiyuki Yamazaki, Yuko Katakai, Noriko Miyake, Shuhei Kameya …

MOLECULAR THERAPY, 25(1) 296-302, Jan, 2017 Peer-reviewed
Treatment of hypophosphatasia by muscle-directed expression of bone-targeted alkaline phosphatase via self-complementary AAV8 vector

Aki Nakamura-Takahashi, Koichi Miyake, Atsushi Watanabe, Yukihiko Hirai, Osamu Iijima, Noriko Miyake, Kumi Adachi, Yuko Nitahara-Kasahara, Hideaki Kinoshita, Taku Noguchi …

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 3 15059, 2016 Peer-reviewed
Prevention of Lethal Murine Hypophosphatasia by Neonatal Ex Vivo Gene Therapy Using Lentivirally Transduced Bone Marrow Cells

Osamu Iijima, Koichi Miyake, Atsushi Watanabe, Noriko Miyake, Tsutomu Igarashi, Chizu Kanokoda, Aki Nakamura-Takahashi, Hideaki Kinoshita, Taku Noguchi, Shinichi Abe …

HUMAN GENE THERAPY, 26(12) 801-812, Dec, 2015 Peer-reviewed
Enzyme replacement in the CSF to treat metachromatic leukodystrophy in mouse model using single intracerebroventricular injection of self-complementary AAV1 vector

Kohei Hironaka, Yoshiyuki Yamazaki, Yukihiko Hirai, Motoko Yamamoto, Noriko Miyake, Koichi Miyake, Takashi Okada, Akio Morita, Takashi Shimada

SCIENTIFIC REPORTS, 5 13104, Aug, 2015 Peer-reviewed
Serotype-independent Method of Recombinant Adeno-associated Virus (AAV) Vector Production and Purification

Koichi Miyake, Noriko Miyake, Yoshiyuki Yamazaki, Takashi Shimada, Yukihiko Hirai

JOURNAL OF NIPPON MEDICAL SCHOOL, 79(6) 394-402, Dec, 2012 Peer-reviewed
アデノ随伴ウイルスベクターの筋注による全身性癌遺伝子治療の開発(Development of adeno-associated viral (AAV) vector mediated muscle directed systemic cancer gene therapy)

三宅弘一, Wang Nanya, 三宅紀子, 猪口孝一, 島田隆

日本癌学会総会記事, 69回 320-320, Aug, 2010
Successful Treatment of Metachromatic Leukodystrophy Using Bone Marrow Transplantation of HoxB4 Overexpressing Cells

Noriko Miyake, Koichi Miyake, Stefan Karlsson, Takashi Shimada

MOLECULAR THERAPY, 18(7) 1373-1378, Jul, 2010 Peer-reviewed
MLL/AF4遺伝子異常を伴う急性リンパ性白血病のMDA7/IL24による遺伝子治療

玉井勇人, 三宅弘一, 三宅紀子, 山口博樹, 檀和夫, 猪口孝一, 島田隆

臨床血液, 50(9) 1114-1114, Sep 30, 2009
Direct comparison of adeno-associated virus serotypes for systemic delivery by monitoring of in vivo quantitative noninvasive imaging

Miyake Koichi, Miyake Noriko, Hirai Yukihiko, Shimada Takashi

JOURNAL OF GENE MEDICINE, 10(4) 450, Apr, 2008 Peer-reviewed
Adeno-associated virus (AAV) type-8 mediated systemic antiangiogenic gene therapy for murine model of multiple myeloma

Miyake Koichi, Isotani Mayu, Miyake Noriko, Shimada Takashi

JOURNAL OF GENE MEDICINE, 10(4) 462, Apr, 2008 Peer-reviewed
Therapeutic effects of bone marrow transplantation for metachromatic leukodystrophy using HOXB4 over-expressing cells

Miyake Noriko, Miyake Koichi, Karlsson Stefan, Shimada Takashi

JOURNAL OF GENE MEDICINE, 10(4) 476-477, Apr, 2008 Peer-reviewed

Misc.

AAVベクターの硝子体投与における内境界膜剥離併用硝子体手術とサル網膜への遺伝子導入改善効果と安全性の検討

五十嵐勉, 高橋和久, 三宅弘一, 小林舞香, 矢口智恵美, 山崎吉之, 三宅紀子, 亀谷修平, 島田隆, 岡田尚巳 …

眼科臨床紀要, 11(7) 554-554, Jul, 2018
アデノ随伴ウイルスベクターによる遺伝子治療と内境界膜剥離

五十嵐勉, 高橋和久, 三宅弘一, 小林舞香, 矢口智恵美, 山崎吉之, 三宅紀子, 亀谷修平, 島田隆, 岡田尚巳 …

日本眼科学会雑誌, 122(3) 251-252, Mar, 2018
サルに対するAAVベクター硝子体投与による血中抗体価の検討

五十嵐勉, 高橋和久, 三宅弘一, 小林舞香, 矢口智恵美, 山崎吉之, 喜納裕美, 三宅紀子, 亀谷修平, 島田隆 …

日本眼科学会雑誌, 122(臨増) 260-260, Mar, 2018
Efficient Transduction of Inner Retina by Surgical Internal Limiting Membrane (ILM) Peeling Before Intravitreal AAV Vector Injection in Cynomolgus Monkeys

Kazuhisa Takahashi, Tsutomu Igarashi, Koichi Miyake, Maika Kobayashi, Chiemi Yaguchi, Osamu Iijima, Yoshiyuki Yamazaki, Noriko Miyake, Shuhei Kameya, Takashi Shimada …

MOLECULAR THERAPY, 25(5) 111-111, May, 2017
Why Are scAAV9 Vectors Able to Pass Through the BBB but Not ssAAV9?; The Difference Between the ssAAV9 and scAAV9 Vector in Transduction of CNS by Intravenous Injection

Noriko Miyake, Koichi Miyake, Motoko Yamamoto, Takashi Shimada, Takashi Okada

MOLECULAR THERAPY, 25(5) 320-321, May, 2017
Tyrosine-mutated AAV2 (Y730, 500, 444F) mediated BDNF rescued inner retina in rat retinal ischemic injury model

M. Kobayashi, T. Igarashi, K. Miyake, N. Miyake, K. Nakamoto, Y. Hirai, H. Takahashi, T. Okada

HUMAN GENE THERAPY, 27(11) A122-A123, Nov, 2016
神経障害性疼痛におけるmiR‐17‐92クラスターによるカリウムチャネルの調節

坂井敦, 丸山基世, 丸山基世, 三宅紀子, 齋藤文仁, 三宅弘一, 島田隆, 岡田尚巳, 鈴木秀典

Pain Research, 31(2) 86, Jun 24, 2016
Successful Treatment of Neonatal Metachromatic Leukodystrophy Model Mice by Low Dose of Self-Complementary AAV Type9 Vector Expressing ASA

Noriko Miyake, Koichi Miyake, Motoko Yamamoto, Takashi Shimada, Takashi Okada

MOLECULAR THERAPY, 24 S63-S63, May, 2016
BDNFを発現するチロシン変異AAV2を用いた網膜虚血モデルにおける神経保護効果

五十嵐勉, 三宅弘一, 小林舞香, 高橋和久, 三宅紀子, 中元兼二, 岡田尚巳, 高橋浩

眼科臨床紀要, 8(10) 772-772, Oct, 2015
網膜一過性虚血モデルにおけるチロシン変異AAV2ベクター由来BDNFの神経保護効果

五十嵐勉, 三宅弘一, 中元兼二, 小林舞香, 亀谷修平, 三宅紀子, 飯島脩, 岡田尚巳, 島田隆, 高橋浩

日本緑内障学会抄録集, 26回 114-114, Sep, 2015
THE D816V C-KIT MUTATION HAS HIGHER ABILITY OF JAK-STAT AND SRC FAMILY KINASE THAN N822K C-KIT MUTATION, AND THEREFORE PROLIFERATION ACTIVITY IS HIGH IN CORE-BINDING FACTOR ACUTE MYELOID LEUKEMIA

I. Omori, H. Yamaguchi, T. Kitano, N. Miyake, K. Miyake, D. Kazuo, K. Inokuchi

HAEMATOLOGICA, 100 353-354, Jun, 2015
Prolonged Survival and Improved Phenotypes of Lethal Hypophosphatasia Model Mice By Adeno-Associated Virus-Mediated Muscle Transduction of Bone-Targeted Alkaline Phosphatase

Aki Nakamura, Koichi Miyake, Atsushi Watanabe, Yukihiko Hirai, Noriko Miyake, Osamu Iijima, Kumi Adachi, Hideaki Kinoshita, Taku Noguchi, Shinichi Abe …

MOLECULAR THERAPY, 23 S282-S282, May, 2015
The D816V C-Kit Mutation Confers Higher Proliferation Activity By JAK-STAT and Src Family Kinase Pathways Compared to N822K C-Kit Mutation in Core-Binding Factor Acute Myeloid Leukemia

Ikuko Omori, Hiroki Yamaguchi, Tomoaki Kitano, Noriko Miyake, Koichi Miyake, Koiti Inokuchi

BLOOD, 124(21), Dec, 2014
Gene Therapy for MLD by Intrathecal Administration of Type 9 AAV Vector Expressing ASA

Noriko Miyake, Koichi Miyake, Atsushi Sakai, Motoko Yamamoto, Ayumi Endo, Hidenori Suzuki, Takashi Shimada

JOURNAL OF GENE MEDICINE, 16(7-8) 252-253, Jul, 2014
AAV Type 8 Mediated Bone-Targeted and Muscle Directed Neonatal Gene Therapy for Hypophosphatasia

Koichi Miyake, Tae Matsumoto, Noriko Miyake, Hideo Orimo, Yoshitaka Fukunaga, Takashi Shimada

JOURNAL OF GENE MEDICINE, 16(7-8) 274-275, Jul, 2014
Direct Comparison of Administration Routes for AAV 8 Mediated Ocular Gene Therapy

Nagisa Asakawa, Tsutomu Igarashi, Noriko Miyake, Koichi Miyake, Takashi Shimada, Hiroshi Takahashi

JOURNAL OF GENE MEDICINE, 16(7-8) 254-255, Jul, 2014
Efficient Protection of Retina By Tyrosine-Mutated Self-Complementary AAV2 Vector Encoding BDNF in a Rat Retinal Ischemic Injury Model

Tsutomu Igarashi, Koichi Miyake, Maika Kobayashi, Kazuhisa Takahashi, Noriko Miyake, Osamu Iijima, Kenji Nakamoto, Yukihiko Hirai, Takashi Shimada, Hiroshi Takahashi

MOLECULAR THERAPY, 22 S47-S47, May, 2014
Successful Treatment of Adult MLD Model Mice By Intravenous Injection of Self-Complementary Type 9 AAV Vector Expressing ASA

Noriko Miyake, Koichi Miyake, Motoko Yamamoto, Takashi Shimada

MOLECULAR THERAPY, 22 S151-S151, May, 2014
Gene therapy of MLD model mice by intrathecal and intravenous injection of AAV9 vector

Noriko Miyake, Koichi Miyake, Takashi Shimada

MOLECULAR GENETICS AND METABOLISM, 111(2) S78-S79, Feb, 2014
一次感覚神経において神経障害性疼痛特異的に発現変化するマイクロRNAの解析

坂井敦, 三宅紀子, 三宅弘一, 島田隆, 鈴木秀典

Pain Research, 29(2), 2014

Books and Other Publications

Gene Delivery into the Central Nervous System (CNS) Using AAV Vectors

Noriko Miyake (Role: Joint author)

Intech, Nov, 2015

Research Projects

リソゾーム病の神経病変を標的とした新規骨髄移植法の開発

科学研究費補助金基盤研究, 文部科学省, 2008 - 2010

三宅紀子
リソゾーム病の神経病変を標的とした新規遺伝子治療の開発

科学研究費補助金若手Ｂ, 文部科学省, 2006 - 2008

三宅紀子

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Committee Memberships

Awards

Papers

Misc.

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