2011年4月4日
Effect of early antiviral agent therapy (NS3 and NS5A inhibitors) in chronic hepatitis C null responders
Acta Hepatologica Japonica
- 巻
- 52
- 号
- 2
- 開始ページ
- 147
- 終了ページ
- 149
- 記述言語
- 日本語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2957/kanzo.52.147
- 出版者・発行元
- Acta Hepatologica Japonica
To further improve therapeutic effect on chronic hepatitis C, we have administered NS3 inhibitor and NS5A inhibitor together, and examined effects of early antiviral agent therapy. The subjects were five cases where interferon is ineffective (null responders). The NS5A and NS3 inhibitors are oral drugs and were daily administered for 24 weeks. Figure 1 shows time-dependent change of the number of viruses after the therapy started, and rapid decrease of viruses is recognized. Within 12 hours, HCV-RNA decreased by more than 2 log IU/ml in every patient. Two patients became negative for the virus by the 15th day after the therapy started. Furthermore, 80% of cases by the 28th day and all the cases by the 56th day became negative. The new therapy has manifested excellent early antiviral effect.<br>
- リンク情報
- ID情報
-
- DOI : 10.2957/kanzo.52.147
- ISSN : 0451-4203
- CiNii Articles ID : 10029285146
- CiNii Books ID : AN00047770