論文

査読有り
2019年2月28日

Environmentally Benign Ritter Reaction Using Bismuth Salts as a Catalyst

European Journal of Organic Chemistry
  • Masaharu Ueno
  • ,
  • Ryo Kusaka
  • ,
  • Satoshi D. Ohmura
  • ,
  • Norikazu Miyoshi

2019
8
開始ページ
1796
終了ページ
1800
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/ejoc.201801882
出版者・発行元
Wiley

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim We developed an environmentally benign Ritter reaction of alcohols with nitriles using a commercially available bismuth salt as a less harmful catalyst. The detailed reaction profiles revealed that consumption of the ether by-product as the reaction proceeded was the key for optimizing this reaction, and the yield of the target amide was improved by adding a small amount of water. This finding clearly reveals the significance of using a bismuth salt as the catalyst, as it is not deactivated in the presence of water. This catalyst system has a broad substrate scope, and even with 1 mol-% of the catalyst, the reaction progresses smoothly. It is also possible to react stoichiometric amounts of nitriles and alcohols, thus reducing the amount of organic solvent required for the reaction. Furthermore, as the inexpensive bismuth catalyst can be easily removed using aqueous hydrochloric acid, a purification process that only required washing and drying without any organic solvents was successfully established.

リンク情報
DOI
https://doi.org/10.1002/ejoc.201801882
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85060954116&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85060954116&origin=inward

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