論文

査読有り
2016年3月

Successful bypass surgery for esophageal carcinoma under adequate factor XIII/13 replacement therapy in a case of intractable autoimmune hemorrhaphilia due to anti-Factor XIII/13 antibodies.

International journal of hematology
  • Minoru Kojima
  • Akitada Ichinose
  • Masayoshi Souri
  • Tsukasa Osaki
  • Hidetsugu Kawai
  • Jun Amaki
  • Hiroki Numata
  • Mitsuki Miyamoto
  • Daisuke Ogiya
  • Kosuke Tsuboi
  • Yoshiaki Ogawa
  • Soji Ozawa
  • Kiyoshi Ando
  • 全て表示

103
3
開始ページ
341
終了ページ
7
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s12185-015-1917-7
出版者・発行元
SPRINGER JAPAN KK

Autoimmune hemorrhaphilia due to anti-factor XIII (FXIII) antibodies (AH13) is a life-threatening disease associated with high risk of surgical bleeding. Since AH13 occurs mainly in the elderly, patients of AH13 tend to be complicated with other life-threatening diseases that may require surgical procedures. During our nation-wide survey on AH13, supported by the Japanese Ministry of Health, Labor, and Welfare, patients with unexplained bleeding were examined for FXIII-related parameters and anti-FXIII autoantibodies. A 64-year-old man had previously been tentatively diagnosed with AH13 and received immunosuppressive therapies, as FXIII inhibitor was detected by functional cross-mixing studies. About 2 years later, he was definitively diagnosed with AH13, because our immuno-chromatographic test and enzyme-linked immuno-sorbent assay detected FXIII-bound anti-FXIII-A subunit autoantibodies. Since routine endoscopic examination revealed suspected esophageal carcinoma, a preparatory FXIII pharmacokinetic (PK) analysis was performed by infusing FXIII concentrates prior to biopsy. Consequently, biopsy of this lesion was done without bleeding complications. One month later, a second PK study was carried out before surgery, and esophageal bypass surgery was completed successfully under FXIII replacement therapy. Our experience with this case suggests that operations can be performed safely and with confidence even in patients with such life-threatening hemorrhagic diseases.

リンク情報
DOI
https://doi.org/10.1007/s12185-015-1917-7
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26619833
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000371254700011&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s12185-015-1917-7
  • ISSN : 0925-5710
  • eISSN : 1865-3774
  • PubMed ID : 26619833
  • Web of Science ID : WOS:000371254700011

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