論文

査読有り 筆頭著者
2008年12月

Activation of TGF-beta/activin signalling resets the circadian clock through rapid induction of Dec1 transcripts

NATURE CELL BIOLOGY
  • Naohiro Kon
  • ,
  • Tsuyoshi Hirota
  • ,
  • Takeshi Kawamoto
  • ,
  • Yukio Kato
  • ,
  • Tadashi Tsubota
  • ,
  • Yoshitaka Fukada

10
12
開始ページ
1463
終了ページ
U197
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/ncb1806
出版者・発行元
NATURE PUBLISHING GROUP

The circadian clock is reset by external time cues for synchronization to environmental changes(1). In mammals, the light-input signalling pathway mediated by Per gene induction has been extensively studied(2,3). On the other hand, little is known about resetting mechanisms that are independent of Per induction(4-6). Here we show that activation of activin receptor-like kinase (ALK), triggered by TGF-beta, activin or alkali signals, evoked resetting of the cellular clock independently of Per induction. The resetting was mediated by an immediate-early induction of Dec1, a gene whose physiological role in the function of the circadian clock has been unclear. Acute Dec1 induction was a prerequisite for ALK-mediated resetting and upregulation was dependent on SMAD3, which was phosphorylated for activation in response to the resetting stimuli. Intraperitoneal injection of TGF-beta into wild-type or Dec1-deficient mice demonstrated that Dec1 has an essential role in phase-shift of clock gene expression in the kidney and adrenal gland. These results indicate that ALK-SMAD3-Dec1 signalling provides an input pathway in the mammalian molecular clock.

リンク情報
DOI
https://doi.org/10.1038/ncb1806
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000261261800018&DestApp=WOS_CPL
ID情報
  • DOI : 10.1038/ncb1806
  • ISSN : 1465-7392
  • Web of Science ID : WOS:000261261800018

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