Papers

Peer-reviewed
11 2003

Molecular characterization of chicken growth hormone secretagogue receptor gene

GENERAL AND COMPARATIVE ENDOCRINOLOGY
  • M Tanaka
  • ,
  • T Miyazaki
  • ,
  • Yamamoto, I
  • ,
  • N Nakai
  • ,
  • Y Ohta
  • ,
  • N Tsushima
  • ,
  • M Wakita
  • ,
  • K Shimada

Volume
134
Number
2
First page
198
Last page
202
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1016/S0016-6480(03)00247-8
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE

Synthetic growth hormone secretagogues stimulate growth hormone secretion by binding to a specific receptor, growth hormone secretagogue receptor (GHS-R). In this study, we investigated the cDNA and the genomic structure of chicken GHS-R. Chicken GHS-R gene is composed of two exons separated by an intron. Two GHS-R mRNA species, cGHS-R1a and cGHS-R1a-variant (cGHS-R1aV) are generated by alternative splicing of a primary transcript. cGHS-R1a protein is predicted to have seven transmembrane domains by a high degree of amino acid sequence identity with mammalian and teleost homologs. cGHS-R1aV lacks the transmembrane-6 domain due to a 48 bp deletion. RT-PCR analysis showed widespread tissue distributions of cGHS-R1a and cGHS-R1aV mRNAs with much higher amounts of cGHS-R1a in all the tissues. (C) 2003 Elsevier Inc. All rights reserved.

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Link information
DOI
https://doi.org/10.1016/S0016-6480(03)00247-8
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/14511992
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000186053800015&DestApp=WOS_CPL

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