2012年2月
Structural basis of transcription by bacterial and eukaryotic RNA polymerases
CURRENT OPINION IN STRUCTURAL BIOLOGY
- ,
- ,
- 巻
- 22
- 号
- 1
- 開始ページ
- 110
- 終了ページ
- 118
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.sbi.2011.11.006
- 出版者・発行元
- CURRENT BIOLOGY LTD
DNA-dependent RNA polymerase (RNAP) is responsible for cellular gene transcription. Although crystallographic studies on prokaryotic and eukaryotic RNAPs have elucidated the basic RNAP architectures, the structural details of many essential events during transcription initiation, elongation, and termination are still largely unknown. Recent crystallographic studies on a bacterial RNAP and yeast RNAP II have revealed different RNAP structural states from that of the normal transcribing complex, as well as the basis of transcription factor functions, advancing our understanding of transcription. These studies have highlighted unexpected similarities in many fundamental aspects of transcription mechanisms between the bacterial and eukaryotic transcription machineries.
Remarkable differences also exist between the bacterial and eukaryotic transcription systems, suggesting directions for future studies.
Remarkable differences also exist between the bacterial and eukaryotic transcription systems, suggesting directions for future studies.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.sbi.2011.11.006
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000301471500016&DestApp=WOS_CPL
- URL
- https://www.sciencedirect.com/science/article/pii/S0959440X11002004?via%3Dihub
- ID情報
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- DOI : 10.1016/j.sbi.2011.11.006
- ISSN : 0959-440X
- Web of Science ID : WOS:000301471500016