Papers

Peer-reviewed
Dec, 2007

Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor

JOURNAL OF BIOLOGICAL CHEMISTRY
  • Chihiro Hisatsune
  • ,
  • Keiko Yasumatsu
  • ,
  • Hiromi Takahashi-Iwanaga
  • ,
  • Naoko Ogawa
  • ,
  • Yukiko Kuroda
  • ,
  • Ryusuke Yoshida
  • ,
  • Yuzo Ninomiya
  • ,
  • Katsuhiko Mikoshiba

Volume
282
Number
51
First page
37225
Last page
37231
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1074/jbc.M705641200
Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

Inositol 1,4,5-trisphosphate receptor (IP3R) is one of the important calcium channels expressed in the endoplasmic reticulum and has been shown to play crucial roles in various physiological phenomena. Type 3 IP3R is expressed in taste cells, but the physiological relevance of this receptor in taste perception in vivo is still unknown. Here, we show that mice lacking IP(3)R3 show abnormal behavioral and electrophysiological responses to sweet, umami, and bitter substances that trigger G-protein-coupled receptor activation. In contrast, responses to salty and acid tastes are largely normal in the mutant mice. We conclude that IP3R3 is a principal mediator of sweet, bitter, and umami taste perception and would be a missing molecule linking phospholipase C beta 2 to TRPM5 activation.

Link information
DOI
https://doi.org/10.1074/jbc.M705641200
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000251646000048&DestApp=WOS_CPL
ID information
  • DOI : 10.1074/jbc.M705641200
  • ISSN : 0021-9258
  • Web of Science ID : WOS:000251646000048

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