Susumu Goyama

Profile Information

Affiliation: 教授, 大学院新領域創成科学研究科メディカルゲノム専攻先進分子腫瘍学分野, 東京大学

Degree: 博士(医学)(Mar, 2006, 東京大学)

Researcher number: 80431849
J-GLOBAL ID: 202001016468456940
researchmap Member ID: R000005675

Research Interests

Research Areas

Life sciences / Hematology and oncology / Hematopoietic Neoplasms, Hematopoietic Stem Cells, Epigenetics, Transcription Factor

Research History

Apr, 2020 - Present

Professor, Division of Molecular Oncology, Graduate School of Frontier Sciences, The University of Tokyo
Mar, 2015 - Mar, 2020

Associate Professor, Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo
Apr, 2012 - Feb, 2015

Research Associate, Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center
Apr, 2010 - 2012

Postdoctoral Fellow for Research Abroad, Cincinnati Children’s Hospital Medical Center
Jul, 2009 - Mar, 2010

Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center
Feb, 2009 - Jun, 2009

Assistant professor, The University of Tokyo Hospital
Apr, 2006 - Jan, 2008

Senior Residency, Department of Hematology and Oncology, The University of Tokyo Hospital
Apr, 2001 - Mar, 2002

Senior Residency, Department of Hematology and Oncology, The University of Tokyo Hospital
Jun, 2000 - Mar, 2001

Residency, the Ibaragi Hitachi Hospital, Ibaragi, Japan, The Ibaragi Hitachi Hospital, Ibaragi, Japan
Jun, 1999 - May, 2000

Residency, The University of Tokyo Hospital

Education

Apr, 2002 - Mar, 2006

Graduate School of Medicine and Faculty of Medicine
Apr, 1993 - Mar, 1999

Graduate School of Medicine and Faculty of Medicine, The University of Tokyo

Papers

BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state.

Muran Xiao, Shinji Kondo, Masaki Nomura, Shinichiro Kato, Koutarou Nishimura, Weijia Zang, Yifan Zhang, Tomohiro Akashi, Aaron Viny, Tsukasa Shigehiro …

Nature communications, 14(1) 8372-8372, Dec 15, 2023
Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment.

Tomohiro Yabushita, Takumi Chinen, Atsuya Nishiyama, Shuhei Asada, Ruka Shimura, Tomoya Isobe, Keita Yamamoto, Naru Sato, Yutaka Enomoto, Yosuke Tanaka …

Cell reports, 42(9) 113098-113098, Sep 26, 2023
Immune checkpoint molecule DNAM-1/CD112 axis is a novel target for NK-cell therapy in acute myeloid leukemia.

Yuta Kaito, Emi Sugimoto, Fumi Nakamura, Yutaka Tsukune, Makoto Sasaki, Shunsuke Yui, Hiroki Yamaguchi, Susumu Goyama, Yasuhito Nannya, Kinuko Mitani …

Haematologica, Sep 21, 2023
Identification of compounds that preferentially suppress the growth of T‐cell acute lymphoblastic leukemia‐derived cells

Kazuya Miyashita, Takuya Yagi, Noritaka Kagaya, Azusa Takechi, Chihiro Nakata, Risa Kanda, Hideko Nuriya, Kosuke Tanegashima, Shota Hoyano, Fumiya Seki …

Cancer Science, 114(10) 4032-4040, Jul 31, 2023
The E3 ligase DTX2 inhibits RUNX1 function by binding its C terminus and prevents the growth of RUNX1-dependent leukemia cells.

Taishi Yonezawa, Hirotaka Takahashi, Yangying Hao, Chie Furukawa, Akiho Tsuchiya, Wenyu Zhang, Tsuyoshi Fukushima, Tomofusa Fukuyama, Tatsuya Sawasaki, Toshio Kitamura …

The FEBS journal, Jul 27, 2023
IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia.

Xiaoxiao Liu, Naru Sato, Tomohiro Yabushita, Jingmei Li, Yuhan Jia, Moe Tamura, Shuhei Asada, Takeshi Fujino, Tsuyoshi Fukushima, Taishi Yonezawa …

EMBO molecular medicine, 15(1) e15631, Dec 1, 2022
TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

Takuma Shibata, Ryota Sato, Masato Taoka, Shin-Ichiroh Saitoh, Mayumi Komine, Kiyoshi Yamaguchi, Susumu Goyama, Yuji Motoi, Jiro Kitaura, Kumi Izawa …

Oct 27, 2022
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.

Tomoya Isobe, Masatoshi Takagi, Aiko Sato-Otsubo, Akira Nishimura, Genta Nagae, Chika Yamagishi, Moe Tamura, Yosuke Tanaka, Shuhei Asada, Reina Takeda …

Nature communications, 13(1) 4501-4501, Aug 30, 2022
Mechanisms involved in hematopoietic stem cell aging.

Takeshi Fujino, Shuhei Asada, Susumu Goyama, Toshio Kitamura

Cellular and molecular life sciences : CMLS, 79(9) 473-473, Aug 8, 2022
MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis.

Yasutaka Hayashi, Kimihito C Kawabata, Yosuke Tanaka, Yasufumi Uehara, Yo Mabuchi, Koichi Murakami, Akira Nishiyama, Shigeru Kiryu, Yusuke Yoshioka, Yasunori Ota …

Cell reports, 39(6) 110805-110805, May 10, 2022
CHIP-associated mutant ASXL1 in blood cells promotes solid tumor progression.

Xiaoxiao Liu, Naru Sato, Yuko Shimosato, Teh-Wei Wang, Tamami Denda, Yu-Hsuan Chang, Tomohiro Yabushita, Takeshi Fujino, Shuhei Asada, Yosuke Tanaka …

Cancer science, 113(4) 1182-1194, Apr, 2022
PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation.

Lomeli C Shull, Ezra S Lencer, Hyun Min Kim, Susumu Goyama, Mineo Kurokawa, James C Costello, Kenneth Jones, Kristin B Artinger

Development (Cambridge, England), 149(4), Feb 15, 2022
Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors.

Yosuke Tanaka, Reina Takeda, Tsuyoshi Fukushima, Keiko Mikami, Shun Tsuchiya, Moe Tamura, Keito Adachi, Terumasa Umemoto, Shuhei Asada, Naoki Watanabe …

Nature communications, 13(1) 271-271, Jan 12, 2022
CRISPR/Cas9-mediated base-editing enables a chain reaction through sequential repair of sgRNA scaffold mutations.

Tsuyoshi Fukushima, Yosuke Tanaka, Keito Adachi, Nanami Masuyama, Akiho Tsuchiya, Shuhei Asada, Soh Ishiguro, Hideto Mori, Motoaki Seki, Nozomu Yachie …

Scientific reports, 11(1) 23889-23889, Dec 13, 2021
Prospective isolation of mouse and human hematopoietic stem cells using Plexin domain containing 2

Yosuke Tanaka, Yasushi Kubota, Ivo Lieberam, Jillian L. Barlow, Josh W. Bramley, Chiaki Sakuma, Takashi Shibata, Masataka Nakagawa, Yasunori Kurosawa, Toshiaki Maruyama …

Sep 27, 2021
MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions.

Elyne Backx, Elke Wauters, Jonathan Baldan, Mathias Van Bulck, Ellis Michiels, Yves Heremans, Diedert Luc De Paep, Mineo Kurokawa, Susumu Goyama, Luc Bouwens …

Cell death and differentiation, 28(9) 2601-2615, Sep, 2021
A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells.

Keita Yamamoto, Susumu Goyama, Shuhei Asada, Takeshi Fujino, Taishi Yonezawa, Naru Sato, Reina Takeda, Akiho Tsuchiya, Tomofusa Fukuyama, Yosuke Tanaka …

Cell reports, 36(8) 109576-109576, Aug 24, 2021
Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway.

Takeshi Fujino, Susumu Goyama, Yuki Sugiura, Daichi Inoue, Shuhei Asada, Satoshi Yamasaki, Akiko Matsumoto, Kiyoshi Yamaguchi, Yumiko Isobe, Akiho Tsuchiya …

Nature communications, 12(1) 1826-1826, Mar 23, 2021
Efficacy of tyrosine kinase inhibitors on a mouse chronic myeloid leukemia model and chronic myeloid leukemia stem cells.

Yosuke Tanaka, Tsuyoshi Fukushima, Keiko Mikami, Keito Adachi, Tomofusa Fukuyama, Susumu Goyama, Toshio Kitamura

Experimental hematology, 90 46-51, Oct, 2020
HHEX promotes myeloid transformation in cooperation with mutant ASXL1.

Reina Takeda, Shuhei Asada, Sung-Joon Park, Akihiko Yokoyama, Hans Jiro Becker, Akinori Kanai, Valeria Visconte, Courtney Hershberger, Yasutaka Hayashi, Taishi Yonezawa …

Blood, 136(14) 1670-1684, Oct 1, 2020 Peer-reviewed

Misc.

The hematopoietic stem cell picture based on their division patterns

田中洋介, 田中洋介, 福島剛, 小出周平, 合山進, 岩間厚志, 須田年生, 北村俊雄

日本再生医療学会総会(Web), 22nd, 2023
Impaired Osteoblastic Differentiation of MSCs Suppresses Normal Hematopoiesis in MDS

Yasutaka Hayashi, Kimihito Cojin Kawabata, Yosuke Tanaka, Yasufumi Uehara, Shigeru Kiryu, Yasunori Ota, Yusuke Yoshioka, Yo Mabuchi, Tatsuki Sugiyama, Keiko Mikami …

BLOOD, 136, Nov, 2020
DTX2はRUNX1のユビキチン化および脱アセチル化を促進し,白血病細胞の増殖を抑制する

米澤大志, 高橋宏隆, 澤崎達也, 北村俊雄, 合山進

日本血液学会学術集会抄録(Web), 82nd, 2020
Asxl1変異とStag2の欠失は協調してクロマチン構造を開き骨髄異形成症候群の発症を誘導する

藤野赳至, 越智陽太郎, 昆彩奈, 合山進, 小川誠司, 北村俊雄

日本血液学会学術集会抄録(Web), 82nd, 2020
The Ubiquitin Ligase DTX2 Promotes Nuclear Export of RUNX1 and Inhibits RUNX1-Dependent Leukemogenesis

Taishi Yonezawa, Hirotaka Takahasi, Tatsuya Sawasaki, Toshio Kitamura, Susumu Goyama

BLOOD, 134, Nov, 2019
Growth Suppressing Activity of Lhx2 in Human T Cell Acute Lymphoblastic Leukemia (T-ALL)-Derived Cells and Large-Scale Screening of a Lead Compounds Targeting T-ALL

Kazuya Miyashita, Noritaka Kagaya, Miho Izumikawa, Kenji Kitajima, Kyoko Watakabe-Inamoto, Yuho Najima, Noriko Doki, Takeshi Kobayashi, Kazuhiko Kakihana, Susumu Goyama …

BLOOD, 128(22), Dec, 2016
Inhibition of Impdh As an Effective Treatment for MLL-Fusion Leukemia

Susumu Goyama, Shiori Shikata, Yasutaka Hayashi, Yuto Izawa, Janet Schibler, Hiroyuki Iwamura, Motoki Saito, Satoshi Kofuji, Kazutaka Sumita, Atsuo T. Sasaki …

BLOOD, 128(22), Dec, 2016
HIGHER EXPRESSION OF ATP-BINDING CASSETTE TRANSPORTER G2 (ABCG2) IS SPECIFIC TO ADVANCED MDS AND PROMOTES INEFFICIENT HEMATOPIESIS VIA CONVERSIONS OF TUMOR MICROENVIRONMENTS IN MOUSE BONE MARROW TRANSPLANTATION MODEL

Kimihito Cojin Kawabata, Yasutaka Hayashi, Daichi Inoue, Hiroki Mizuno, Jiro Kitaura, Yosuke Tanaka, Susumu Goyama, Yuka Harada, Hironori Harada, Hiroyuki Aburatani …

EXPERIMENTAL HEMATOLOGY, 44(9) S110-S110, Sep, 2016
ANALYSIS OF MDS MICE MODEL INDUCED BY ASXL1 AND RUNX1 MUTANTS

Reim Nagase, Daichi Inoue, Makoto Saika, Hsin-An Hou, Wen-Chien Chou, Kimihito Kawabata, Hironori Harada, Akinori Kanai, Susumu Goyama, Hiroaki Honda …

EXPERIMENTAL HEMATOLOGY, 44(9) S90-S90, Sep, 2016
A Patient-Derived EZH2 Mutant Induces MDS-like Diseases with Derepressed ABCG2 Expression in Mice

Kimihito Cojin Kawabata, Daichi Inoue, Jiro Kitaura, Yuka Harada, Susumu Goyama, Hironori Harada, Hiroyuki Aburatani, Toshio Kitamura

BLOOD, 126(23), Dec, 2015
INACTIVATION OF EZH2 BY TRANCATED FORM MUTAION DE-REPRESSES NOVEL TARGET GENES TO PROMOTE TUMOR-INITIATING CAPACITY

Kimihito Cojin Kawabata, Daichi Inoue, Susumu Goyama, Hironori Harada, Jiro Kitaura, Toshio Kitamura

EXPERIMENTAL HEMATOLOGY, 43(9) S51-S51, Sep, 2015
NOVEL ROLES OF ASXL1 IN EPIGENETIC REGULATION

Daichi Inoue, Sayuri Horikawa, Hirotaka Matsui, Reina Nagase, Makoto Saika, Kimihito C. Kawabata, Susumu Goyama, Toshio Kitamura

EXPERIMENTAL HEMATOLOGY, 43(9) S69-S69, Sep, 2015
Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia

Tomohiko Sato, Susumu Goyama, Keisuke Kataoka, Ryo Nasu, Takako Tsuruta-Kishino, Yuki Kagoya, Arika Nukina, Katsuyoshi Kumagai, Naoto Kubota, Masahiro Nakagawa …

CANCER RESEARCH, 74(19), Oct, 2014
Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells (vol 123, pg 3876, 2013)

Susumu Goyama, Janet Schibler, Lea Cunningham, Yue Zhang, Yalan Rao, Nahoko Nishimoto, Masahiro Nakagawa, Andre Olsson, Mark Wunderlich, Kevin A. Link …

JOURNAL OF CLINICAL INVESTIGATION, 123(11) 4979-4979, Nov, 2013
Regulation of Chronic Myelogenous Leukemia Stem Cells by Leukemia Oncogene Evi1

Tomohiko Sato, Susumu Goyama, Keisuke Kataoka, Takako Tsuruta, Masahiro Nakagawa, Keiki Kumano, Katsuyoshi Kumagai, Naoto Kubota, Takashi Kadowaki, Mineo Kurokawa

BLOOD, 118(21) 440-441, Nov, 2011
Evil Is a Stem Cell-Specific Regulator of Self-Renewal Capacity In the Definitive Hematopoietic System

Keisuke Kataoka, Tomohiko Sato, Akihide Yoshimi, Susumu Goyama, Takako Tsuruta, Shunya Arai, Yoichi Imai, Katsuyoshi Kumagai, Naoto Kubota, Takashi Kadowaki …

BLOOD, 116(21) 365-365, Nov, 2010
Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells

58(3) 354-360, Mar, 2009
Evi-1 Interacts with Histone Methyltransferases for Transcription Repression and Bone Marrow Transformation

Susumu Goyama, Eriko Nitta, Munetake Shimabe, Tetsuya Yoshino, Shinichi Kako, Motoshi Ichikawa, Yoichi Imai, Tsuyoshi Takahashi, Akira Hangaishi, Mineo Kurokawa

BLOOD, 112(11) 787-788, Nov, 2008
Evi-1 promotes para-aortic splanchnopleural hematopoiesis through up-regulation of GATA-2 and repression of TGF-beta signaling.

Tomohiko Sato, Susumu Goyama, Mineo Kurokawa

BLOOD, 110(11) 374A-374A, Nov, 2007
Phosphorylation of AML1/Runx1 is essential for T cell differentiation and early hematopoietic development

Mayumi Yoshimi, Susumu Goyama, Masahiro Nakagawa, Takashi Asai, Motoshi Ichikawa, Mineo Kurokawa

BLOOD, 110(11) 651A-651A, Nov, 2007

Professional Memberships

Research Projects

Identification of tumor driver lncRNAs in myeloid tumors and development of lncRNA-targeting therapies

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2026
骨髄系腫瘍におけるドライバーlncRNAの同定とlncRNA標的医薬の開発

科学研究費助成事業基盤研究(B), 基盤研究(B), 文部科学省, 2022 - 2025

合山進, 高橋宏隆, 長門石曉
膜のない構造体パラスペックルの生体内での役割と生物学的意義の解明を目指して

科学研究費助成事業挑戦的研究(萌芽), 挑戦的研究(萌芽), 日本学術振興会, Jun, 2022 - Mar, 2024

北村俊雄, 合山進
Identification of the cell of origin of infant leukemia with pluripotency

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2022 - Mar, 2024
Development of proteostasis modulators targeting the co-chaperon E3 ligase STUB1

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2023
Ab initio法を活用した造血系腫瘍におけるlncRNAの統合的機能解析

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

森努, 合山進
Targeting transcription and epigenetic factors through modulation of protein-protein interactions

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2023
Crosstalk between clonal hematopoiesis and solid tumors

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2021

Goyama Susumu
Analyses of relationship between clonal hematopoiesis associated with leukemia-related gene mutations and leukemia/solid tumors/cardiovascular diseases

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2020

Kitamura Toshio
Ab initio analysis on the pathophysiology of hematopoietic neoplasms

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2017 - Mar, 2019

Mori Tsutomu, KAWAMURA Takashi
Crosstalk between epigenetic therapy and anti-tumor immunity in the treatment of hematopoietic neoplasms

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

Goyama Susumu, Hayashi Yasutaka, Saika Makoto, Yonezawa Taishi, Liu XiaoXiao
造血系転写因子RUNX1のユビキチン化修飾および分解制御機構の解明

科学研究費助成事業研究活動スタート支援, 研究活動スタート支援, 日本学術振興会, Aug, 2015 - Mar, 2016

合山進
Establishment of experimental model for leukemia to develop novel molecular therapy

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2008 - 2009

GOYAMA Susumu
Evi1による造血幹細胞及び癌化の制御機構

科学研究費助成事業若手研究(スタートアップ), 若手研究(スタートアップ), 日本学術振興会, 2006 - 2007

合山進
Comprehensive analysis of oncogenic transcriptional factor Evi-1.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2005 - 2006

KUROKAWA Mineo, HANGAISHI Akira, IZUTSU Koji, GOYAMA Susumu

Profile Information

Research Interests

Research Areas

Research History

Education

Papers

Misc.

Professional Memberships

Research Projects

Menu

Coauthors