論文

査読有り
2016年5月

Preserved Nephrogenesis Following Partial Nephrectomy in Early Neonates

SCIENTIFIC REPORTS
  • Yuhei Kirita
  • ,
  • Daisuke Kami
  • ,
  • Ryo Ishida
  • ,
  • Takaomi Adachi
  • ,
  • Keiichi Tamagaki
  • ,
  • Satoaki Matoba
  • ,
  • Tetsuro Kusaba
  • ,
  • Satoshi Gojo

6
開始ページ
26792
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/srep26792
出版者・発行元
NATURE PUBLISHING GROUP

Reconstitution of total nephron segments after resection in the adult kidney has not been achieved; however, whether the neonatal kidney can maintain the capacity for neo-nephrogenesis after resection is unknown. We performed partial resection of the kidney in neonatal rats on postnatal days 1 (P1x kidney) and 4 (P4x kidney) and examined morphological changes and relevant factors. The P1x kidney bulged into the newly formed cortex from the wound edge, while nephrogenesis failure was prominent in the P4x kidney. Twenty-eight days post-resection, the glomerular number, cortex area, and collecting duct were preserved in the P1x kidney, whereas these parameters were markedly decreased in the P4x kidney. During normal development, Six2 expression and Six2+ nephron progenitor cells in the cap mesenchyme both rapidly disappear after birth. However, time course analysis for the P1x kidney showed that Six2 expression and Six2+ cells were well preserved in the tissue surrounding the resected area even 2 days after resection. In conclusion, our results indicate that kidneys in early neonate rats retain the capability for neo-nephrogenesis after resection; however, this ability is lost soon after birth, which may be attributed to a declining amount of Six2+ cells.

Web of Science ® 被引用回数 : 1

リンク情報
DOI
https://doi.org/10.1038/srep26792
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27244673
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000392060600001&DestApp=WOS_CPL

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