論文

査読有り
2017年7月

Sexual dimorphisms of mRNA and miRNA in human/murine heart disease

PLOS ONE
  • Masato Tsuji
  • ,
  • Takanori Kawasaki
  • ,
  • Takeru Matsuda
  • ,
  • Tomio Arai
  • ,
  • Satoshi Gojo
  • ,
  • Jun K. Takeuchi

12
7
開始ページ
e0177988
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.0177988
出版者・発行元
PUBLIC LIBRARY SCIENCE

Background Sexual dimorphisms are well recognized in various cardiac diseases such as ischemic cardiomyopathy (ICM), hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Thorough understanding of the underlying genetic programs is crucial to optimize treatment strategies specified for each gender. By performing meta-analysis and microarray analysis, we sought to comprehensively characterize the sexual dimorphisms in the healthy and diseased heart at the level of both mRNA and miRNA transcriptome.
Results Existing mRNA microarray data of both mouse and human heart were integrated, identifying dozens/hundreds of sexually dimorphic genes in healthy heart, ICM, HCM, and DCM. These sexually dimorphic genes overrepresented gene ontologies (GOs) important for cardiac homeostasis. Further, microarray of miRNA, isolated from mouse sham left ventricle (LV) (n = 6 & n = 5 for male & female) and chronic MI LV (n = 19 & n = 19) and from human normal LV (n = 6 & n = 6) and ICM LV (n = 4 & n = 5), was conducted. This revealed that 13 mouse miRNAs are sexually dimorphic in MI and 6 in normal heart. In human, 3 miRNAs were sexually dimorphic in ICM and 15 in normal heart. These data revealed miRNA-mRNA networks that operate in a sexually-biased fashion.
Conclusions mRNA and miRNA transcriptome of normal and disease heart show significant sex differences, which might impact the cardiac homeostasis. Together this study provides the first comprehensive picture of the genome-wide program underlying the heart sexual dimorphisms, laying the foundation for gender specific treatment strategies.

Web of Science ® 被引用回数 : 12

リンク情報
DOI
https://doi.org/10.1371/journal.pone.0177988
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28704447
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000405649700005&DestApp=WOS_CPL

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