2022年4月
Estimated Isotopic Compositions of Yb in Enriched Yb-176 for Producing Lu-177 with High Radionuclide Purity by Yb-176(d,x) Lu-177
JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN
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- 巻
- 91
- 号
- 4
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.7566/JPSJ.91.044201
- 出版者・発行元
- PHYSICAL SOC JAPAN
Recently, great interest has arisen concerning Lu-177 as one of the most important therapeutic radionuclides for treating neuroendocrine tumors. This has driven demand for Lu-177 with high radionuclide purity produced in accelerators, by using highly enriched Yb-176 samples to develop a variety of mix-labelled radiopharmaceuticals. In this paper, a method is presented to estimate isotopic compositions of enriched Yb-176 samples required for achieving large-scale production of Lu-177 having high radionuclide purity by the Yb-176(d,x)Lu-177 reaction. These isotopic compositions were estimated using the latest measured excitation functions of the Yb-nat(d,x)Lu reaction that were confirmed in this study by measuring the integral yields of the reaction, and a particle transport simulation code. The estimated radionuclide purity of Lu-177 for commercially available enriched Yb-176 sample is over 99% at a deuteron energy of 20MeV. The method plays an important role in determining isotopic compositions of enriched samples for producing high purity medical radionuclides in accelerators.
- リンク情報
- ID情報
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- DOI : 10.7566/JPSJ.91.044201
- ISSN : 0031-9015
- Web of Science ID : WOS:000785988000009