論文

査読有り 筆頭著者
2015年2月

Multiple invasions of an infectious retrovirus in cat genomes

SCIENTIFIC REPORTS
  • Sayumi Shimode
  • ,
  • So Nakagawa
  • ,
  • Takayuki Miyazawa

5
開始ページ
8164
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/srep08164
出版者・発行元
NATURE PUBLISHING GROUP

Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections of host germ-line cells. While most ERVs are defective, some are active and express viral proteins. The RD-114 virus is a replication-competent feline ERV, and several feline cell lines produce infectious RD-114 viral particles. All domestic cats are considered to have an ERV locus encoding a replication-competent RD-114 virus in their genomes; however, the locus has not been identified. In this study, we investigated RD-114 virus-related proviral loci in genomes of domestic cats, and found that none were capable of producing infectious viruses. We also found that all domestic cats have an RD-114 virus-related sequence on chromosome C2, termed RDRS C2a, but populations of the other RDRSs are different depending on the regions where cats live or breed. Our results indicate that RDRS C2a, the oldest RD-114-related provirus, entered the host genome before an ancestor of domestic cats started diverging and the other new RDRSs might have integrated into migrating cats in Europe. We also show that infectious RD-114 virus can be resurrected by the recombination between two non-infectious RDRSs. From these data, we conclude that cats do not harbor infectious RD-114 viral loci in their genomes and RD-114-related viruses invaded cat genomes multiple times.

リンク情報
DOI
https://doi.org/10.1038/srep08164
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25641657
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000348670200005&DestApp=WOS_CPL
ID情報
  • DOI : 10.1038/srep08164
  • ISSN : 2045-2322
  • PubMed ID : 25641657
  • Web of Science ID : WOS:000348670200005

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