論文

査読有り 国際誌
2020年7月23日

Succeeding in deactivating: associations of hair zinc levels with functional and structural neural mechanisms.

Scientific reports
  • Hikaru Takeuchi
  • ,
  • Yasuyuki Taki
  • ,
  • Rui Nouchi
  • ,
  • Ryoichi Yokoyama
  • ,
  • Yuka Kotozaki
  • ,
  • Seishu Nakagawa
  • ,
  • Atsushi Sekiguchi
  • ,
  • Kunio Iizuka
  • ,
  • Sugiko Hanawa
  • ,
  • Tsuyoshi Araki
  • ,
  • Carlos Makoto Miyauchi
  • ,
  • Kohei Sakaki
  • ,
  • Takayuki Nozawa
  • ,
  • Shigeyuki Ikeda
  • ,
  • Susum Yokota
  • ,
  • Daniele Magistro
  • ,
  • Yuko Sassa
  • ,
  • Ryuta Kawashima

10
1
開始ページ
12364
終了ページ
12364
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-020-69277-4

Zinc is a biologically essential element and involved in a wide range of cellular processes. Here, we investigated the associations of zinc levels in hair with brain activity during the n-back working memory task using functional magnetic resonance imaging, fractional anisotropy (FA) of diffusion tensor imaging, and cognitive differences in a study cohort of 924 healthy young adults. Our findings showed that greater hair zinc levels were associated with lower brain activity during working memory in extensive areas in the default mode network (i.e., greater task-induced deactivation) as well as greater FA in white matter areas near the hippocampus and posterior limbs of the internal capsule. These findings advance previous non-neuroimaging findings of zinc's associations with excitability, excitability-associated disorders, and myelination.

リンク情報
DOI
https://doi.org/10.1038/s41598-020-69277-4
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32704167
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378227
ID情報
  • DOI : 10.1038/s41598-020-69277-4
  • PubMed ID : 32704167
  • PubMed Central 記事ID : PMC7378227

エクスポート
BibTeX RIS