2020年7月
Succeeding in deactivating: associations of hair zinc levels with functional and structural neural mechanisms
SCIENTIFIC REPORTS
- 巻
- 10
- 号
- 1
- 開始ページ
- 12364
- 終了ページ
- 12364
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41598-020-69277-4
- 出版者・発行元
- NATURE PUBLISHING GROUP
Zinc is a biologically essential element and involved in a wide range of cellular processes. Here, we investigated the associations of zinc levels in hair with brain activity during the n-back working memory task using functional magnetic resonance imaging, fractional anisotropy (FA) of diffusion tensor imaging, and cognitive differences in a study cohort of 924 healthy young adults. Our findings showed that greater hair zinc levels were associated with lower brain activity during working memory in extensive areas in the default mode network (i.e., greater task-induced deactivation) as well as greater FA in white matter areas near the hippocampus and posterior limbs of the internal capsule. These findings advance previous non-neuroimaging findings of zinc's associations with excitability, excitability-associated disorders, and myelination.
- リンク情報
-
- DOI
- https://doi.org/10.1038/s41598-020-69277-4
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/32704167
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378227
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000556690900071&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1038/s41598-020-69277-4
- ISSN : 2045-2322
- PubMed ID : 32704167
- PubMed Central 記事ID : PMC7378227
- Web of Science ID : WOS:000556690900071