論文

国際誌
2021年1月1日

Sex-Dependent Effects of the APOE ɛ4 Allele on Behavioral Traits and White Matter Structures in Young Adults.

Cerebral cortex (New York, N.Y. : 1991)
  • Hikaru Takeuchi
  • ,
  • Hiroaki Tomita
  • ,
  • Ryan Browne
  • ,
  • Yasuyuki Taki
  • ,
  • Yoshie Kikuchi
  • ,
  • Chiaki Ono
  • ,
  • Zhiqian Yu
  • ,
  • Rui Nouchi
  • ,
  • Ryoichi Yokoyama
  • ,
  • Yuka Kotozaki
  • ,
  • Seishu Nakagawa
  • ,
  • Atsushi Sekiguchi
  • ,
  • Kunio Iizuka
  • ,
  • Sugiko Hanawa
  • ,
  • Tsuyoshi Araki
  • ,
  • Carlos Makoto Miyauchi
  • ,
  • Kohei Sakaki
  • ,
  • Takayuki Nozawa
  • ,
  • Shigeyuki Ikeda
  • ,
  • Susumu Yokota
  • ,
  • Daniele Magistro
  • ,
  • Yuko Sassa
  • ,
  • Ryuta Kawashima

31
1
開始ページ
672
終了ページ
680
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/cercor/bhaa251

The APOE ɛ4 allele is associated with a risk of Alzheimer's disease in the elderly, with the association being pronounced in females. Conversely, findings of the effects of the APOE ɛ4 allele in young adults are mixed. Here, we investigated the sex-genotype interaction effects of the APOE ɛ4 allele on cognitive functions as well as brain structures among 1258 young adults. After adjusting for multiple comparisons, there were significant effects of the interaction between sex and the number of APOE ɛ4 allele on some speed tasks (e.g., simple processing speed tasks and the reverse Stroop task) as well as on regional white matter volume (rWMV). The observed sex-genotype interaction conferred better cognitive performance and greater rWMV in the anterior frontal and precentral white matter areas in females having more APOE ɛ4 alleles and reduced rWMV in the same areas in male having more APOE ɛ4 alleles. These findings support the long-debated antagonistic pleiotropic effects of the APOE ɛ4 allele in females.

リンク情報
DOI
https://doi.org/10.1093/cercor/bhaa251
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32954402
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727389
ID情報
  • DOI : 10.1093/cercor/bhaa251
  • PubMed ID : 32954402
  • PubMed Central 記事ID : PMC7727389

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