論文

国際誌
2020年5月8日

VGLUT2-expressing neurons in the vestibular nuclear complex mediate gravitational stress-induced hypothermia in mice.

Communications biology
  • Chikara Abe
  • ,
  • Yusuke Yamaoka
  • ,
  • Yui Maejima
  • ,
  • Tomoe Mikami
  • ,
  • Shigefumi Yokota
  • ,
  • Akihiro Yamanaka
  • ,
  • Hironobu Morita

3
1
開始ページ
227
終了ページ
227
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s42003-020-0950-0

The vestibular system, which is essential for maintaining balance, contributes to the sympathetic response. Although this response is involved in hypergravity load-induced hypothermia in mice, the underlying mechanism remains unknown. This study showed that hypergravity (2g) decreased plasma catecholamines, which resulted in hypoactivity of the interscapular brown adipose tissue (iBAT). Hypothermia induced by 2g load was significantly suppressed by administration of beta-adrenergic receptor agonists, suggesting the involvement of decrease in iBAT activity through sympathoinhibition. Bilateral chemogenetic activation of vesicular glutamate transporter 2 (VGLUT2)-expressing neurons in the vestibular nuclear complex (VNC) induced hypothermia. The VGLUT2-expressing neurons contributed to 2g load-induced hypothermia, since their deletion suppressed hypothermia. Although activation of vesicular gamma-aminobutyric acid transporter-expressing neurons in the VNC induced slight hypothermia instead of hyperthermia, their deletion did not affect 2g load-induced hypothermia. Thus, we concluded that 2g load-induced hypothermia resulted from sympathoinhibition via the activation of VGLUT2-expressing neurons in the VNC.

リンク情報
DOI
https://doi.org/10.1038/s42003-020-0950-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32385401
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210111
ID情報
  • DOI : 10.1038/s42003-020-0950-0
  • PubMed ID : 32385401
  • PubMed Central 記事ID : PMC7210111

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