Shigefumi Yokota

Profile Information

Affiliation: Faculty of Medicine, School of Medicine, Shimane University

Degree: Master (science)(Shimane University)

J-GLOBAL ID: 200901002810699214
researchmap Member ID: 1000263098

Research Interests

Research Areas

Papers

Dual orexin receptor blocker suvorexant attenuates hypercapnic ventilatory augmentation in mice

Isato Fukushi, Shigefumi Yokota, Kotaro Takeda, Jiro Terada, Akira Umeda, Masashi Yoshizawa, Yosuke Kono, Yohei Hasebe, Hiroshi Onimaru, Mieczyslaw Pokorski …

Brain Research, 1795 148061-148061, Aug, 2022
Coherence analysis of the calcium activity of putative astrocytic and neuronal cells on the L5 ventral horn and neural output in activated lumbar CPG networks

Itaru Yazawa, Shuntaro Okazaki, Shigefumi Yokota, Kotaro Takeda, Isato Fukushi, Masashi Yoshizawa, Hiroshi Onimaru, Yasumasa Okada

Neuroscience Letters, 771 136421-136421, Feb, 2022
Structural and functional connectivity from the dorsomedial hypothalamus to the ventral medulla as a chronological amplifier of sympathetic outflow.

Yosuke Kono, Shigefumi Yokota, Isato Fukushi, Yosuke Arima, Hiroshi Onimaru, Shuntaro Okazaki, Kotaro Takeda, Itaru Yazawa, Masashi Yoshizawa, Yohei Hasebe …

Scientific reports, 10(1) 13325-13325, Aug 7, 2020 Peer-reviewed
Blockade of astrocytic activation delays the occurrence of severe hypoxia-induced seizure and respiratory arrest in mice.

Isato Fukushi, Kotaro Takeda, Makoto Uchiyama, Yuki Kurita, Mieczyslaw Pokorski, Shigefumi Yokota, Shuntaro Okazaki, Jouji Horiuchi, Yasuo Mori, Yasumasa Okada

The Journal of comparative neurology, 528(8) 1257-1264, Jun, 2020 Peer-reviewed
VGLUT2-expressing neurons in the vestibular nuclear complex mediate gravitational stress-induced hypothermia in mice.

Chikara Abe, Yusuke Yamaoka, Yui Maejima, Tomoe Mikami, Shigefumi Yokota, Akihiro Yamanaka, Hironobu Morita

Communications biology, 3(1) 227-227, May 8, 2020
The role of the hypothalamus in modulation of respiration

Isato Fukushi, Shigefumi Yokota, Yasumasa Okada

Respiratory Physiology & Neurobiology, 265 172-179, Jul, 2019 Peer-reviewed
New nociceptive circuits to the hypothalamic perifornical area from the spinal cord and spinal trigeminal nucleus via the parabrachial nucleus.

Asano H, Arima Y, Yokota S, Fujitani M

Biochemical and biophysical research communications, 512(4) 705-711, May, 2019 Peer-reviewed
経血管灌流標本を用いたマウス孤束核抑制性投射ニューロンによる呼吸リズムの修飾機構の解析

濱徳行, 横田茂文, 藤谷昌司, 岡田泰昌, 越谷直弘, 小泉英彦

日本生理学雑誌, 81(2) 40-40, May, 2019
Lateral parabrachial neurons innervate orexin neurons projecting to brainstem arousal areas in the rat.

Arima Y, Yokota S, Fujitani F

Scientific Reports, 9(1) 2830, Feb, 2019 Peer-reviewed
Structural and functional identification of two distinct inspiratory neuronal populations at the level of the phrenic nucleus in the rat cervical spinal cord

Yoshio Shinozaki, Shigefumi Yokota, Fumikazu Miwakeichi, Mieczyslaw Pokorski, Ryoma Aoyama, Kentaro Fukuda, Hideaki Yoshida, Yoshiaki Toyama, Masaya Nakamura, Yasumasa Okada

BRAIN STRUCTURE & FUNCTION, 224(1) 57-72, Jan, 2019 Peer-reviewed
ラット視床下部背内側野から延髄腹側循環中枢群に至る神経路の形態学的解析

河野洋介, 有馬陽介, 横田茂文, 鬼丸洋, 福士勇人, 小泉敬一, 長谷部洋平, 吉沢雅史, 喜瀬広亮, 戸田孝子 …

日本高血圧学会総会プログラム・抄録集, 41回 OB02-03, Sep, 2018 Peer-reviewed
A potential contribution of tenascin-X to blood vessel formation in-peripheral nerves

Hiromichi Sakai, Shigefumi Yokota, Naoyo Kajitani, Tsunao Yoneyama, Kohei Kawakami, Yukihiko Yasui, Ken-ichi Matsumoto

NEUROSCIENCE RESEARCH, 124 1-7, Nov, 2017 Peer-reviewed
Kolliker-Fuse GABAergic and glutamatergic neurons project to distinct targets

Joel C. Geerling, Shigefumi Yokota, Irma Rukhadze, Dan Roe, Nancy L. Chamberlin

JOURNAL OF COMPARATIVE NEUROLOGY, 525(8) 1844-1860, Jun, 2017 Peer-reviewed
The respiratory control mechanisms in the brainstem and spinal cord: integrative views of the neuroanatomy and neurophysiology

Keiko Ikeda, Kiyoshi Kawakami, Hiroshi Onimaru, Yasumasa Okada, Shigefumi Yokota, Naohiro Koshiya, Yoshitaka Oku, Makito Iizuka, Hidehiko Koizumi

JOURNAL OF PHYSIOLOGICAL SCIENCES, 67(1) 45-62, Jan, 2017 Peer-reviewed
Orexinergic fibers are in contact with Kolliker-Fuse nucleus neurons projecting to the respiration-related nuclei in the medulla oblongata and spinal cord of the rat

Shigefumi Yokota, Tatsuro Oka, Hirohiko Asano, Yukihiko Yasui

BRAIN RESEARCH, 1648(Pt A) 512-523, Oct, 2016 Peer-reviewed
Effects of arundic acid, an astrocytic modulator, on the cerebral and respiratory functions in severe hypoxia

Isato Fukushi, Kotaro Takeda, Shigefumi Yokota, Yohei Hasebe, Yutaka Sato, Mieczyslaw Pokorski, Jouji Horiuchi, Yasumasa Okada

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 226 24-29, Jun, 2016 Peer-reviewed
Respiratory-Related Outputs of Glutamatergic, Hypercapnia-Responsive Parabrachial Neurons in Mice

Shigefumi Yokota, Satvinder Kaur, Veronique G. VanderHorst, Clifford B. Saper, Nancy L. Chamberlin

JOURNAL OF COMPARATIVE NEUROLOGY, 523(6) 907-920, Apr, 2015 Peer-reviewed
ANATOMICAL AND FUNCTIONAL PATHWAYS OF RHYTHMOGENIC INSPIRATORY PREMOTOR INFORMATION FLOW ORIGINATING IN THE PRE-BOTZINGER COMPLEX IN THE RAT MEDULLA

N. Koshiya, Y. Oku, S. Yokota, Y. Oyamada, Y. Yasui, Y. Okada

NEUROSCIENCE, 268 194-211, May, 2014 Peer-reviewed
Standardization of Size, Shape and Internal Structure of Spinal Cord Images: Comparison of Three Transformation Methods

Yasuhisa Fujiki, Shigefumi Yokota, Yasumasa Okada, Yoshitaka Oku, Yoshiyasu Tamura, Makio Ishiguro, Fumikazu Miwakeichi

PLOS ONE, 8(11) e76415, Nov, 2013 Peer-reviewed
Intrapancreatic ganglia neurons receive projection fibers from melanocortin-4 receptor-expressing neurons in the dorsal motor nucleus of the vagus nerve of the mouse

Toshiko Tsumori, Tatsuro Oka, Shigefumi Yokota, Jian-Guo Niu, Yukihiko Yasui

BRAIN RESEARCH, 1537 132-142, Nov, 2013 Peer-reviewed

Misc.

今あらためて考えよう高血圧成因研究の意義高血圧成因に関する基礎研究における新たな展開視床下部へのテタヌス刺激は延髄腹側部に刺激後も遷延する神経活動を誘発する膜電位感受性色素を用いたイメージングによるダイナミック解析(Tetanic Stimulation of the Hypothalamus Evokes Post Stimulus Persistent Activation of the Ventrolateral Medulla: Visualization Analysis Using a

河野洋介, 鬼丸洋, 福士勇人, 岡崎俊太郎, 横田茂文, 武田湖太郎, 長谷部洋平, 岡田泰昌

日本高血圧学会総会プログラム・抄録集, 40回 251-251, Oct, 2017
Respiratory-Related Outputs of Glutamatergic, Hypercapnia-Responsive Parabrachial Neurons in Mice

Shigefumi Yokota, Satvinder Kaur, Veronique G. VanderHorst, Clifford B. Saper, Nancy L. Chamberlin

JOURNAL OF COMPARATIVE NEUROLOGY, 523(6) 907-920, Apr, 2015
ANATOMICAL AND FUNCTIONAL PATHWAYS OF RHYTHMOGENIC INSPIRATORY PREMOTOR INFORMATION FLOW ORIGINATING IN THE PRE-BOTZINGER COMPLEX IN THE RAT MEDULLA

N. Koshiya, Y. Oku, S. Yokota, Y. Oyamada, Y. Yasui, Y. Okada

NEUROSCIENCE, 268 194-211, May, 2014
ラットKoelliker-Fuse核は舌下神経核へグルタミン酸作動性投射をする

横田茂文, 津森登志子, 岡達郎, 牛建国, 安井幸彦

解剖学雑誌, 85(2), 2010
Spatiotemporal activity of respiratory neurons in and near the phrenic nucleus

Yoshio Shinozaki, Shigefumi Yokota, Fumikazu Miwakeichi, Ryoma Aoyama, Yoshitaka Oku, Yasumasa Okada

NEUROSCIENCE RESEARCH, 65 S72-S72, 2009
Neuroanatomical and neurochemical organization of projections from the central amygdaloid nucleus to the nucleus retroambiguus via the periaqueductal gray in the rat

Tatsuro Oka, Toshiko Tsumori, Shigefumi Yokota, Yukihiko Yasui

NEUROSCIENCE RESEARCH, 62(4) 286-298, Dec, 2008
GABAergic neurons in the ventrolateral subnucleus of the nucleus tractus solitarius are in contact with Kolliker-Fuse nucleus neurons projecting to the rostral ventral respiratory group and phrenic nucleus in the rat

Shigefumi Yokota, Toshiko Tsumori, Tatsuro Oka, Sawako Nakamura, Yukihiko Yasui

BRAIN RESEARCH, 1228 113-126, Sep, 2008
頸髄横隔神経核の自発呼吸神経活動のCO2濃度変化に対する応答膜電位イメージング法による解析

篠崎義雄, 岡田泰昌, 青山龍馬, 福田健太郎, 吉田英彰, 中村雅也, 横田茂文, 安井幸彦, 越久仁敬, 千葉一裕 …

日本整形外科学会雑誌, 82(8) S1127-S1127, Aug, 2008
Posterior lateral hypothalamic axon terminals are in contact with trigeminal

Notsu K, Tsumori T, Yokota S, Sekine J, Yasui Y

Brain Research, 1244 71-81, 2008
A disynaptic pathway from the central amygdaloid nucleus to the paraventricular hypothalamic nucleus via the parastrial nucleus in the rat

Ken Tsubouchi, Toshiko Tsumori, Shigefumi Yokota, Hideki Okunishi, Yukihiko Yasui

NEUROSCIENCE RESEARCH, 59(4) 390-398, Dec, 2007
Glutamatergic neurons in the Kolliker-Fuse nucleus project to the rostral ventral respiratory group and phrenic nucleus: A combined retrograde tracing and in situ hybridization study in the rat

Shigefumi Yokota, Tatsuro Oka, Toshiko Tsumori, Sawako Nakamura, Yukihiko Yasui

NEUROSCIENCE RESEARCH, 59(3) 341-346, Nov, 2007
ラット視床下部から三叉神経運動核への制御経路について

野津一樹, 吉村安郎, 安井幸彦, 津森登志子, 横田茂文

日本口腔科学会雑誌, 56(3), 2007
A light and electron microscopic analysis of the convergent insular cortical and amygdaloid projections to the posterior lateral hypothalamus in the rat, with special reference to cardiovascular function

Toshiko Tsumori, Shigefumi Yokota, Yi Qin, Tatsuro Oka, Yukihiko Yasui

NEUROSCIENCE RESEARCH, 56(3) 261-269, Nov, 2006
Insular cortical and amygdaloid fibers are in contact with posterolateral hypothalamic neurons projecting to the nucleus of the solitary tract in the rat

Toshiko Tsumori, Shigefumi Yokota, Toshiro Kishi, Yi Qin, Tatsuro Oka, Yukihiko Yasui

Brain Research, 1070(1) 139-144, Jan 27, 2006
Topographical projection from the hippocampal formation to the amygdala: A combined anterograde and retrograde tracing study in the rat.

Kishi, T, Tsumori, T, Yokota, S, Yasui, Y

J. Comp. Neurol., 496(3) 349-368, 2006
Amygdaloid axon terminals are in contact with trigeminal premotor neurons in the parvicellular reticular formation of the rat medulla oblongata

Yukihiko Yasui, Toshiko Tsumori, Tatsuro Oka, Shigefumi Yokota

Brain Research, 1016(1) 129-134, Jul 30, 2004
Nigrothalamostriatal and nigrothalamocortical pathways via the ventrolateral parafascicular nucleus

Toshiko Tsumori, Shigefumi Yokota, Katsuhiko Ono, Yukihiko Yasui

NeuroReport, 14(1) 81-86, Jan 20, 2003
延髄における菱脳唇由来の細胞の移動パターンと分化

小野勝彦, 横田茂文, 津森登志子, 安井幸彦

解剖学雑誌, 78(Supplement), 2003
Glutamatergic pathways from the Kölliker-Fuse nucleus to the phrenic nucleus in the rat.（jointly worked）

Brain Res, in press, 2003
Synaptic organization of GABAergic projections from the substantia nigra pars reticulata and the reticular thalamic nucleus to the parafascicular thalamic nucleus in the rat

T Tsumori, S Yokota, K Ono, Y Yasui

BRAIN RESEARCH, 957(2) 231-241, Dec, 2002

Presentations

Physiological and morphological study of the neuronal mechanism underlying respiratory control by inhibitory neurons in the solitary nucleus

Noriyuki Hama, Kotaro Takeda, Yasumasa Okada, Naohiro Koshiya, Hidehiko Koizumi

第126回日本解剖学会総会・全国学術集会・第98回日本生理学会大会合同大会
Pathways of hypoxia-induced respiratory and cortical arousal.

Shigefumi Yokota, Noriyuki Hama, Kotaro Takeda, Yasumasa Okada

第126回日本解剖学会総会・全国学術集会・第98回日本生理学会大会合同大会
マウス孤束核興奮性ニューロンによる呼吸調節機構の解析

濱徳行, 横田茂文, 藤谷昌司, 岡田泰昌, 越谷直弘, 小泉英彦

日本生理学会第72回中国四国地方会
遺伝子改変動物を用いた孤束核グルタミン酸作動性ニューロンによる呼吸循環調節機構の解析

横田茂文, 武田湖太郎, 濱徳行, 有馬陽介, 藤谷昌司, 岡田泰昌

日本生理学会第72回中国四国地方会
血中低酸素情報を伝達する孤束核から結合腕傍核を介して視床下部へ至る神経路

横田茂文, 濱徳行, 武田湖太郎, 藤谷昌司

第125回日本解剖学会総会・全国学術集会, Mar 28, 2020
A dual orexin receptor blocker suvorexant inhibits hypercapnic ventilatory augmentation.

Fukushi F, Yokota S, Takeda K, Terada J, Okada Y

第97回日本生理学会大会
Decrease in the expiratory duration induced by the photostimulation of inhibitory neurons within the lateral solitary nucleus during inspiration

Hama H Yokota S, Fujitani M, Okada Y, Koshiya N, Koizumi H

第97回日本生理学会大会
The pathway transmitting hypoxia information from the solitary nucleus to the hypothalamus.

Yokota S, Hama N, Takeda K, Fujitani M

第97回日本生理学会大会, Mar 17, 2020
孤束核抑制性投射ニューロンによる呼息相の短縮

濱徳行, 横田茂文, 藤谷昌司, 岡田泰昌, 越谷直弘, 小泉英彦

日本生理学会第71回中国四国地方会
Dual blockade of orexin receptors does not affect ventilation in mice.

Fukushi I, Yokota S, Takeda K, Terada J, Okada Y

The 24th Congress of the Asian Pacific Society of Respirology (APSR 2019)
ラット外側結合腕傍核は脳幹覚醒調節領域へ投射する視床下部オレキシン産生ニューロンを支配する

有馬陽介, 横田茂文, 藤谷昌司

日本解剖学会第74回中国・四国支部学術集会
孤束核グルタミン酸作動性ニューロンによる呼吸循環調節機構の機能的・形態学的解析

横田茂文, 武田湖太郎, 濱徳行, 有馬陽介, 藤谷昌司, 岡田泰昌

日本解剖学会第74回中国・四国支部学術集会
Dual orexin receptor antagonism and ventilatory function in mice.

Fukushi I, Yokota S, Takeda K, Terada J, Okada Y

The 48th Annual Meeting Society for Neuroscience
Effects of a dual orexin receptor blocker suvorexant on breathing

Fukushi I, Yokota S, Takeda K, Terada J, Okada Y

第42回神経科学大会
Function of inhibitory neurons in the solitary tract in the control of respiration.

Hama N, Yokota S, Fujitani M, Okada Y, Koshiya N, Koizumi H

The 9th FAOPS Congress
Astrocytes mediate persistent respiratory augmentation in the recovery phase after hypoxic exposure.

Fukushi I, Kono Y, Takeda K, Okazaki S, Yokota S, Yazawa I, Onimaru H, Okada Y

The 9th FAOPS Congress
Effects of suvorexant (Belsomra(R)) on ventilation in mice.

Fukushi I, Yokota S, Takeda K, Okazaki S, Terada J, Okada Y

第５９回日本呼吸器学会学術講演会
孤束核グルタミン酸作動性ニューロンによる呼吸循環調節

横田茂文, 武田湖太郎, 濱徳行, 有馬陽介, 岡田泰昌

第124回日本解剖学会総会･全国学術集会
Lateral parabrachial neurons innervate orexin neurons projecting to brainstem arousal areas in the rat.

Arima Y, Yokota S

第124回日本解剖学会総会･全国学術集会
Cardiorespiratory regulation by glutamatergic neurons in the caudal solitary nucleus

YOKOTA Shigefumi

The 47th Annual Meeting Society for Neuroscience, Nov 3, 2018

Professional Memberships

Research Projects

Morphological exploration of cognitive neurocircuits for the gustatory brain-machine interface

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
母体の栄養状態による新生児突然死症候群発症のメカニズムの解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

濱徳行, 横田茂文
Identification and elucidation of neural circuits causing hypertension associated with obstructive sleep apnea

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
Genetic mechanisms of salt preference in rats and humans

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2025
Elucidation of neurological disoders in neonatal jaaundice

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
体性感覚野へ上行する内臓感覚求心路の未知の脳幹中継核を光学的マッピングで同定する

科学研究費補助金基盤研究（C）, 日本学術振興会, Apr, 2019 - Mar, 2022

伊藤眞一
橋結合腕傍核による眠気・覚醒度制御機構の解明：リハビリ効率向上のための基礎的検討

科学研究費補助金基盤研究（C）, 日本学術振興会, Apr, 2019 - Mar, 2022

横田茂文
経血管灌流標本を用いた内臓感覚性呼吸リズム調節を実現する神経ネットワークの解明

科学研究費補助金基盤研究（C）, 日本学術振興会, Apr, 2018 - Mar, 2021

濱徳行
Analysis of respiratory neuronal network dynamics in the sleep-wake mode circuit controlled by orexin

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Arata Akiko, YAMANAKA Akihiro, YOKOTA Shigefumi, WATSON Charles
遺伝子改変動物を利用した喉頭運動調節神経機構の機能形態学的解析

科学研究費補助金基盤研究（C）, 日本学術振興会, Apr, 2015 - Mar, 2017

横田茂文
痛み刺激による覚醒反応の神経回路を実験形態学的に解析する

科学研究費補助金基盤研究（C）, 日本学術振興会, Apr, 2015 - Mar, 2017

安井幸彦
オレキシンニューロンへの侵害性入力を実験形態学的に視る

科学研究費補助金基盤研究（C）, 日本学術振興会, Apr, 2012 - Mar, 2015

安井幸彦
オレキシンによる脳幹呼吸調節機構の修飾作用ー幼若動物と成熟動物との比較検討ー

科学研究費補助金, 2012 - 2014
視床下部レプチン・メラノコルチン系摂食回路への内臓感覚入力を実験形態学的に視る

科学研究費補助金基盤研究（C）, 日本学術振興会, Apr, 2009 - Mar, 2012

安井幸彦
呼吸リズムパターン形成に関わる頚髄呼吸神経回路網の全容解明

科学研究費補助金基盤研究（C）, 日本学術振興会, Apr, 2008 - Mar, 2011

岡田泰昌
辺縁系によるレプチン・メラノコルチン系摂食回路の修飾機構を実験形態学的に視る

科学研究費補助金基盤研究（C）, 日本学術振興会, Apr, 2007 - Mar, 2009

安井幸彦
呼吸リズム形成ニューロンの活動を制制する神経路の実験形態学的解析

科学研究費補助金若手研究（B）, 日本学術振興会, Apr, 2004 - Mar, 2006

横田茂文
オリゴデンドロサイトの発生における移動と軸索との相互作用の解析

科学研究費助成事業, 特定領域研究(A), 日本学術振興会, 1998 - 1998

小野勝彦, 横田茂文, 津森登志子, 安井幸彦
Physiological and Morphorogical analysis of osmoregulatory cells in teleosts.
Morphological study on neuronal circuits of the autonomic nervous system

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