Shigeru Sasaki

J-GLOBAL         Last updated: Jul 4, 2019 at 19:05
 
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Name
Shigeru Sasaki
E-mail
s-sasakihoshi.ac.jp
Affiliation
Hoshi University

Published Papers

 
Shigeru Sasaki, Satono Watanabe, Kaori Shiino, Yuko Yanaka, Shiho Kaneko, Kana Miyamoto, Ayano Yasui, Hina Sakaino, Hiroyoshi Teramoto, Takayasu Yamauchi, Kimio Higashiyama
Heterocycles   97 823-841   Jan 2018
© 2018 The Japan Institute of Heterocyclic Chemistry This paper discusses the reactivity of various 2-substituted aziridine derivatives. The reaction of chiral 2-aryl-substituted aziridines with triethylamine trihydrofluoride (Et3N·3HF) afforded c...
Hiroyoshi Teramoto, Takayasu Yamauchi, Yasushi Terado, Sanae Odagiri, Shigeru Sasaki, Kimio Higashiyama
Chemical and Pharmaceutical Bulletin   64 410-419   May 2016
© 2016 The Pharmaceutical Society of Japan.The matrine-type alkaloid 4-dimethylamino-1-pentanoylpiperidine (3a) has an antinociceptive effect through its impact on the κ-opioid receptor (KOR). Derivatives of 3a were synthesized by altering its ami...
Hiroyoshi Teramoto, Takayasu Yamauchi, Shigeru Sasaki, Kimio Higashiyama
Chemical and Pharmaceutical Bulletin   64 420-431   May 2016
© 2016 The Pharmaceutical Society of Japan.A series of new κ opioid receptor (KOR) agonists were developed from the lead compound 4-dimethylamino-1-pentanoylpiperidine (3), a matrine-type alkaloid. Derivatives of 3 were synthesized with a variety ...
Shigeru Sasaki, Tatuo Suzuki, Toshihiro Uchiya, Shigenobu Toyota, Akira Hirano, Mao Tanemura, Hiroyoshi Teramoto, Takayasu Yamauchi, Kimio Higashiyama
Journal of Fluorine Chemistry   192 78-85   Jan 2016
© 2016 Elsevier B.V.We herein present an efficient method for the construction of α,α-difluoro-β-hydroxy ketones. The La(OTf)3-catalyzed aldol reaction between difluoroenol O-Boc (Boc = tert-butyloxycarbonyl) esters and carbonyl compounds affords ...
Shigeru Sasaki, Takayasu Yamauchi, Masatomi Kanai, Akihiro Ishii, Kimio Higashiyama
Bulletin of the Chemical Society of Japan   88 200-208   Jan 2015
© 2014 The Chemical Society of Japan. Bisoxazoline (BOX)-catalyzed asymmetric nucleophilic addition of diethyl zinc to fluorinated alkyl ketones successfully afforded enantioenriched fluorinated alkyl tertiary alcohols. The effect of the size of t...