Shigeru Sasaki

J-GLOBAL         Last updated: Sep 22, 2018 at 22:19
 
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Name
Shigeru Sasaki
E-mail
s-sasakihoshi.ac.jp
Affiliation
Hoshi University

Published Papers

 
Hiroyoshi Teramoto, Takayasu Yamauchi, Yasushi Terado, Sanae Odagiri, Shigeru Sasaki, Kimio Higashiyama
Chemical and Pharmaceutical Bulletin   64 410-419   May 2016
© 2016 The Pharmaceutical Society of Japan.The matrine-type alkaloid 4-dimethylamino-1-pentanoylpiperidine (3a) has an antinociceptive effect through its impact on the κ-opioid receptor (KOR). Derivatives of 3a were synthesized by altering its ami...
Hiroyoshi Teramoto, Takayasu Yamauchi, Shigeru Sasaki, Kimio Higashiyama
Chemical and Pharmaceutical Bulletin   64 420-431   May 2016
© 2016 The Pharmaceutical Society of Japan.A series of new κ opioid receptor (KOR) agonists were developed from the lead compound 4-dimethylamino-1-pentanoylpiperidine (3), a matrine-type alkaloid. Derivatives of 3 were synthesized with a variety ...
Shigeru Sasaki, Tatuo Suzuki, Toshihiro Uchiya, Shigenobu Toyota, Akira Hirano, Mao Tanemura, Hiroyoshi Teramoto, Takayasu Yamauchi, Kimio Higashiyama
Journal of Fluorine Chemistry   192 78-85   Jan 2016
© 2016 Elsevier B.V.We herein present an efficient method for the construction of α,α-difluoro-β-hydroxy ketones. The La(OTf)3-catalyzed aldol reaction between difluoroenol O-Boc (Boc = tert-butyloxycarbonyl) esters and carbonyl compounds affords ...
Shigeru Sasaki, Takayasu Yamauchi, Masatomi Kanai, Akihiro Ishii, Kimio Higashiyama
Bulletin of the Chemical Society of Japan   88 200-208   Jan 2015
© 2014 The Chemical Society of Japan. Bisoxazoline (BOX)-catalyzed asymmetric nucleophilic addition of diethyl zinc to fluorinated alkyl ketones successfully afforded enantioenriched fluorinated alkyl tertiary alcohols. The effect of the size of t...
Takayasu Yamauchi, Jun Ichi Takidaira, Kenya Okamoto, Takaya Sugiura, Hiroki Horikoshi, Shintaro Kudo, Shigeru Sasaki, Noriko Mizushima, Kimio Higashiyama
Heterocycles   88 1175-1189   Jan 2014
Total synthesis of (3R,16Z,20E,23S)- and (3R,16Z,20E,23R)-eushearilide was accomplished in 15 steps, respectively. Using either enantiomer of one of the four building blocks to assemble the phosphonium salt for the latter Wittig reaction, two dias...