論文

査読有り 国際誌
2020年5月10日

Prognostic significance of perioperative C-reactive protein in resected non-small cell lung cancer.

Seminars in thoracic and cardiovascular surgery
  • Satoru Okada
  • ,
  • Masanori Shimomura
  • ,
  • Hiroaki Tsunezuka
  • ,
  • Satoshi Teramukai
  • ,
  • Shunta Ishihara
  • ,
  • Junichi Shimada
  • ,
  • Masayoshi Inoue

記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1053/j.semtcvs.2020.03.019

Inflammation is reportedly associated with the development and progression of various malignancies. However, the clinical significance of preoperative and postoperative inflammation in lung cancer patients undergoing surgery is unknown. The relationship between preoperative and postoperative C-reactive protein (CRP), an indicator of inflammation, and survival was retrospectively analyzed in 356 patients who underwent complete resection of pathological Stage I and II non-small cell lung cancers. Cutoffs for preoperative CRP (CRPpre), postoperative maximum levels of CRP (CRPmax), and postoperative CRP levels 30 days after surgery (CRP30) were determined as 0.2 mg/dL, 6.4 mg/dL, and 0.2 mg/dL, respectively. Patients with CRPprehigh, CRPmaxhigh, or CRP30high status had significantly poorer overall survival (OS) and relapse-free survival (RFS) than those with CRPprelow, CRPmaxlow, or CRP30low. Patients were stratified into 4 groups according to perioperative CRP grades, combining CRPprehigh, CRPmaxhigh, and CRP30high statuses, yielding groups with grades 0, 1, 2, and 3. OS and RFS significantly worsened with increasing grade. After controlling for potential confounders, the multivariate Cox proportional hazard model revealed perioperative CRP grade as an independent poor prognostic factor for OS (grade 3 vs. grade 0): adjusted hazard ratio [HR], 5.05; 95% confidence interval [CI], 1.59-19.6; p = 0.005), and RFS (adjusted HR, 3.62; 95% CI, 1.50-9.33; p = 0.004). Perioperative inflammation was associated with a long-term negative prognostic impact after lobectomy for lung cancer. Further prospective analysis is required to identify whether control of perioperative inflammation may improve prognosis after lung cancer surgery.

リンク情報
DOI
https://doi.org/10.1053/j.semtcvs.2020.03.019
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32437868