Aya Shiraki

Profile Information

Affiliation: Faculty of Medicine Department of Internal Medicine, Saga University

Degree: 博士（医学）(Mar, 2012)

Researcher number: 50638252
J-GLOBAL ID: 202401006053473060
researchmap Member ID: R000075163

Research Areas

Life sciences / Internal medicine - General /

Major Research History

Apr, 2023 - Present

特任教授, 循環器内科, 佐賀大学医学部
Apr, 2022

教授, 医工循環器学講座寄附講座, 佐賀大学医学部
Apr, 2020

Faculty of Medicine Department of Medical Engineering Cardiology, Department of Geriatric Cardiology, Saga University School of Medicine

Major Education

Apr, 2006 - Mar, 2012

佐賀大学医学部博士課程
Apr, 1996 - Mar, 2002

佐賀医科大学

Major Awards

Papers

Clinical effects of a selective urate reabsorption inhibitor dotinurad in patients with hyperuricemia and treated hypertension: a multicenter, prospective, exploratory study (DIANA)

Tanaka A, Taguchi I, Hisauchi I, Yoshida H, Shimabukuro M, Hongo H, Ishikawa T, Kadokami T, Yagi S, Sata M, Node K; DIANA study investigators(Tetsuya Kaneko, Kohei Kaneta, Masahiro Natsuaki, Aya Shiraki, Shinjo Sonoda, Ayumu Yajima, Kensuke Yokoi, Goro Yoshioka et al.)

Eur J Med Res, 28(1) 238, Jul, 2023
Linagliptin exacerbates heart failure due to energy deficiency via downregulation of glucose utilization and absorption in a mouse model

Shiraki A, Oyama JI, Shimizu T, Node K

Eur J Pharmacol, 948 175673, Jun, 2023
Empagliflozin improves cardiac mitochondrial function and survival through energy regulation in a murine model of heart failure

Aya Shiraki, Jun-Ichi Oyama, Takahiko Shimizu, Takayuki Nakajima, Takashi Yokota, Koichi Node

Eur J Pharmacol, 931 175194, Sep, 2022
Author Correction: A novel soluble epoxide hydrolase vaccine protects murine cardiac muscle against myocardial infarction

*Takahiro Kitsuka, Aya Shiraki, Jun-Ichi Oyama, Hironori Nakagami, Atsushi Tanaka, Koichi Node

Sci Rep, 12(1) 7737, May, 2022
A novel soluble epoxide hydrolase vaccine protects murine cardiac muscle against myocardial infarction

*Takahiro Kitsuka, Aya Shiraki, Jun-Ichi Oyama, Hironori Nakagami, Atsushi Tanaka, Koichi Node

Sci Rep, 12(1) 6923, Apr, 2022
Simple risk-score model for in-hospital major bleeding based on multiple blood variables in patients with acute myocardial infarction

○Yuhei Goriki, Goro Yoshioka, Masahiro Natsuaki, Kodai Shinzato, Kensaku Nishihira, Nehiro Kuriyama, Mitsuhiro Shimomura, Yohei Inoue, Toshiyuki Nishikido, Tetsuya Kaneko, Kensuke Yokoi, Ayumu Yajima, Yoshiko Sakamoto, Motoko Tago, Atsushi Kawaguchi, Fumi Yamamoto, Atsushi Tanaka, Takanori Yamaguchi, Aya Shiraki, Machiko Asaka, Norihiko Kotooka, Shinjo Sonoda, Yutaka Hikichi, Yoshisato Shibata, Koichi Node

Int J Cardiol, 346 45298, Jan, 2022
Does cilnidipine, a dual L- and N-type Ca 2+ blocker, shows promise in drug repositioning approaches?

Aya Shiraki, Kana Nakashima, Koichi Node

Hypertens Res, 43(7) 726-728, Jul, 2020
GLP-1 analog liraglutide-induced cardiac dysfunction due to energetic starvation in heart failure with non-diabetic dilated cardiomyopathy.

Shiraki A, Oyama JI, Nishikido T, Node K.

Cardiovasc Diabetol., 18(1) 164, Nov, 2019
COA-Cl (2-Cl-C.OXT-A) can promote coronary collateral development following acute myocardial infarction in mice.

○Nishikido T, Oyama JI, Shiraki A, Tsukamoto I, Igarashi J, Node K.

Sci Rep., 9(1) 2533, 2019
Azelnidipine Inhibits the Differentiation and Activation of THP-1 Macrophages through the L-Type Calcium Channel.

*Komoda H, Shiraki A, Oyama JI, Nishikido T, Node K.

J Atheroscler Thromb., 25(8) 690-697, 2018
Efficacy and safety of sitagliptin in elderly patients with type 2 diabetes mellitus.

Tago M, Oyama JI, Sakamoto Y, Shiraki A, Uchida F, Chihara A, Ikeda H, Kuroki S, Gondo S, Iwamoto T, Uchida Y, Node K.

Geriatr Gerontol Int., 18(4) 631-639, 2018
EGCG, a green tea catechin, attenuates the progression of heart failure induced by the heart/muscle-specific deletion of MnSOD in mice

○Jun-Ichi Oyama, Aya Shiraki, Toshiyuki Nishikido, Toyoki Maeda, Hiroshi Komoda, Takahiko Shimizu, Naoki Makino, Koichi Node

J Cardiol ., 69(2) 417-427, Feb, 2017

Books and Other Publications

可溶性エポキシドヒドロラーゼをターゲットとしたペプチドワクチンは心筋梗塞後のリモデリングを抑制する

*木塚貴浩, 白木綾, 中神啓徳, 田中敦史, 野出孝一 (Role: Joint author)

一般社団法人日本内分泌学会, Mar, 2022 Peer-reviewed

Presentations

A Novel Prediction Model of in-Hospital Major Bleeding Based on the Multiple Blood Variables in Patients with Acute Myocardial Infarction

合力悠平, 夏秋政浩, 吉岡吾郎, 新里広大, 西平賢作, 栗山根廣, 井上洋平, 金子哲也, 横井研介, 多胡素子, 矢島あゆむ, 坂本佳子, 山元芙美, 田中敦史, 山口尊則, 下村光洋, 白木綾, 園田信成, 挽地裕, 柴田剛徳, 野出孝一

第87回日本循環器学会学術集会(JCS2023)（ハイブリッド開催）, 2023, 3,10-12(現地開催), 2023, 3,20- 4,20(オンデマンド配信), 2023, 一般社団法人日本循環器学会
術前に肺高血圧症の合併が疑われたTSH産生下垂体腺腫の一例

*荒木大夢, 高柳宏樹, 江頭志穂, 吉富裕加, 久冨茜音, 美奈川仁美, 山崎有菜, 白木綾, 安西慶三

第96回日本内分泌学会学術総会（ハイブリッド開催）, 2023, 6, 1-3(現地開催), 2023, 6, 1- 7,31(オンデマンド配信), 2023, 一般社団法人日本内分泌学会
急性心筋梗塞における血液検査のみに基づく出血性合併症予測モデルの構築

○合力悠平, 夏秋政浩, 吉岡吾郎, 新里広大, 西平賢作, 栗山根廣, 下村光洋, 井上洋平, 横井研介, 矢島あゆむ, 坂本佳子, 多胡素子, 山元芙美, 田中敦史, 山口尊則, 白木綾, 園田信成, 挽地裕, 柴田剛徳, 野出孝一

第133回日本循環器学会九州地方会/第35回日本心血管インターベンション治療学会九州・沖縄地方会/第7回冬季症例検討会合同開催（ハイブリッド開催）, 2022,12, 3(現地開催及びライブ配信), Dec, 2022, (一社)日本循環器学会/(一社)日本心血管インターベンション治療学会
A Novel Soluble Epoxide Hydrolase Vaccine Protects Murine Cardiac Muscle Against Myocardial Infarction

Aya Shiraki, Takahiro Kitsuka, Junichi Oyama, Hironori Nakagami, Koichi Node

JSH2022/ISH2022 KYOTO/APSH2022 同時開催, 2022,10,12-16, Oct, 2022, The Japanese Society of Hypertension
The DPP4 inhibitor linagliptin exacerbated heart failure due to energy deficiency via downregulation of glucose absorption and utilization in mice

Aya Shiraki, Jun-ichi Oyama, T. Shimizu, Koichi Node

ESC Congress 2022(Hybrid format), 2022, 8,26-29(On-site+On-line), Aug, 2022
ダイバーシティ～循環器内科の立場から～

白木綾, 野出孝一

第15回日本性差医学・医療学会学術集会（WEB開催）, 2022, 2,19-20(ライブ配信), 2022, 2,19- 3, 7(オンデマンド配信), 2022, 日本性差医学・医療学会 Invited
A Novel Soluble Epoxide Hydrolase Peptide Vaccine Attenuates Cardiac Remodeling After Myocardial Infarction Through Angiogenesis

*Takahiro Kitsuka, Aya Shiraki, Jun-ichi Oyama, Hironori Nakagami, Atsushi Tanaka and Koichi Node

AHA Scientific Sessions 2021 (Virtual Event), 2021,11,13-15, Nov, 2021
Empagliflozin improves prognosis and energetic properties through modulating mitochondrial function in failing murine hearts

A Shiraki, J Oyama, T Shimizu, T Nakajima, T Yokota, K Node

ESC Congress 2021 -The Digital Experience (Online Meeting), 2021, 8,27-30, Aug, 2021
LP-1アナログリラグルチドは不全心において糖依存を増強し予後を変化させる

白木綾, 野出孝一

第6回日本心血管協会学術集会（オンライン開催）, 2021, 4,24-25(ZOOM), Apr, 2021, 認定特定非営利活動法人日本心血管協会
非糖尿病性拡張型心筋症の動物モデルにおいて、GLP-1アナログは心筋のエネルギー欠乏状態を引き起こす

白木綾、尾山純一、野出孝一

第129回日本循環器学会九州地方会 (WEB開催), 2020, 12, 5 (ライブ配信), 2020,12,11-2021, 1, 8(オンデマンド配信), 2020
Cardiac Dysfunction Induced by Incretin-Related Drugs Due to Energetic Starvation in Non-Diabetic Failing Heart

Aya Shiraki, Junichi Oyama, Koichi Node

AHA Scientific Sessions 2019, 2019, 11, 16-18, 2019
EGCG は酸化ストレス抑制作用により、食塩感受性ラットにおける心肥大を抑制する

白木綾

第22回日本心血管内分泌代謝学会学術総会（CVEM2018）第91回日本内分泌学会学術総会同時開催, 2018.4.28-29, 2018
EGCG attenuate cardiac hypertrophy in the hypertensive Dahl rats.

Shiraki A, Oyama JI, Node K

ISH 2018 -The 27th Scientific Meeting of the International Society of Hypertension (Hypertension Beijing 2018), The 14th Congress of the Asian Pacific Society of Hypertension (APSH), The 20th International Symposium on Hypertension and Related Diseases, and the 2018 Chinese Hypertension Meeting (CHL), 2018.9.20-23, 2018
Losing body weight is a strong independent predictor of rehospitalization and prognosis in patients with heart failure.

Nishikido T, Oyama JI, Nagatomo D, Shiraki A, Node K.

ESC Congress 2018, 2018.8.25-29, 2018

Profile Information

Research Areas

Major Research History

Major Education

Major Awards

Papers

Books and Other Publications

Presentations

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