論文

査読有り
2019年

Intestinal helminth infections in HIV-infected patients in Savannakhet after establishment of an HIV registration network in Lao People's Democratic Republic.

Tropical medicine and health
  • Yukako Kaneshiro
  • Khamphang Sourinphoumy
  • Naoki Imaizumi
  • Mangkhalar Rasaphon
  • Megumi Kuba-Miyara
  • Shugo Sakihama
  • Carmina Louise Hugo Guerrero
  • Ketsaphone Nhativong
  • Daisuke Nonaka
  • Tiengkham Pongvongsa
  • Jun Kobayashi
  • Sengchanh Kounnavong
  • Takuya Fukushima
  • 全て表示

47
開始ページ
14
終了ページ
14
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s41182-019-0142-0

Background: In Lao People's Democratic Republic (PDR), which borders China, Vietnam, Cambodia, Thailand, and Myanmar, the number of HIV-infected patients has increased in recent years. HIV-infected patients diagnosed in Lao PDR are enrolled in a registration network and receive antiretroviral therapy (ART) covered by governmental financial support. Based on the registration network, we investigated intestinal helminth infections and coinfection with HTLV-1 in HIV-infected patients treated with an early intervention using ART in Lao PDR. Methods: This cross-sectional study of all 252 HIV-infected patients at Savannakhet Provincial Hospital, located in the southern part of Lao PDR, was conducted between February and March 2018. Socioepidemiological information and clinical information were collected from a registration network database and by questionnaire administered to participants. Microscopic examination of intestinal helminth infections in stool samples and particle agglutination for anti-HTLV-1 antibody in plasma were performed. Results: The median age of all 252 participants was 39 years old (range, 18-59). Based on the registration network database, there were 156 (61.9%) HIV-infected patients with a CD4-positive cell count ≥ 200 cells/μL and 146 (57.9%) with an HIV viral load < 250 copies/mL. Among 212 stool samples, 75 (35.4%) were found to contain one or more intestinal helminth species, including Opisthorchis viverrini (16.5%), Strongyloides stercoralis (10.8%), hookworm (10.4%), and Taenia saginata (3.3%). This rate of intestinal helminth infections was lower than that of a previous report conducted before the establishment of the registration network for HIV-infected patients in Lao PDR. There was no significant association between intestinal helminth infections and a lower CD4-positive T cell count or higher HIV viral load. HIV-infected patients with anti-HTLV-1 antibody positivity were not found in this cohort. Conclusion: The registration network and an early intervention using ART may provide good medical care and improve the clinical course of HIV-infected patients in Lao PDR. However, the incidence of intestinal helminth infections remains high at 35.4%. The development of a specific medical care system for helminth infection for HIV-infected patients is necessary.

リンク情報
DOI
https://doi.org/10.1186/s41182-019-0142-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30804703
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371529
ID情報
  • DOI : 10.1186/s41182-019-0142-0
  • ISSN : 1348-8945
  • PubMed ID : 30804703
  • PubMed Central 記事ID : PMC6371529

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