2017年1月
Highly Efficient Kinetic Resolution of PHANOL by Chiral Phosphoric Acid Catalyzed Asymmetric Acylation
SYNTHESIS-STUTTGART
- ,
- ,
- 巻
- 49
- 号
- 2
- 開始ページ
- 365
- 終了ページ
- 370
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1055/s-0036-1588898
- 出版者・発行元
- GEORG THIEME VERLAG KG
We report herein a highly efficient kinetic resolution of PHANOL by chiral phosphoric acid catalyzed asymmetric acylation. PHANOL enantiomers were well differentiated by the chiral environment of chiral phosphoric acid, and both the corresponding monoester and PHANOL were obtained with excellent enantioselectivities (98% ee and 92% ee, respectively). Detailed examination of the substrates suggests that the presence of two hydroxy groups in PHANOL was critical for both reactivity and enantioselectivity.
- リンク情報
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- DOI
- https://doi.org/10.1055/s-0036-1588898
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000393232500016&DestApp=WOS_CPL
- URL
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84991243461&origin=inward
- ID情報
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- DOI : 10.1055/s-0036-1588898
- ISSN : 0039-7881
- eISSN : 1437-210X
- SCOPUS ID : 84991243461
- Web of Science ID : WOS:000393232500016