Teruaki Oku

Profile Information

Affiliation: 講師, 薬学部, 星薬科大学

Degree: 博士（薬学）(星薬科大学)

J-GLOBAL ID: 201601014432781776
researchmap Member ID: B000253509

External link: https://kaken.nii.ac.jp/d/r/20409361.ja.html

Research Areas

Research History

Apr, 2016 - Present

Hoshi University, Hoshi University

Papers

A Novel Modified Monocyte Activation Test as an Alternative Method to the Pyrogen Test

Teruaki OKU, Yutaka KIKUCHI

Pharmaceutical;Medical Device Regulatory Science, 53(5) 440-445, Dec, 2022
マクロファージにおけるCoronin-1発現制御機構の解析

安藤祐介, 金子豊, 長谷川晋也, 築地信, 渡辺知恵, 奥輝明

日本生化学会大会プログラム・講演要旨集, 95回 1P-387, Nov, 2022
COL8A1 facilitates the growth of triple-negative breast cancer via FAK/Src activation.

Fumiaki Sato, Atsunobu Sagara, Kaede Tajima, Shotaro Miura, Kenjiro Inaba, Yusuke Ando, Teruaki Oku, Takashi Murakami, Yoshinori Kato, Tetsuro Yumoto

Breast cancer research and treatment, 194(2) 243-256, May 28, 2022
Sulfated Hyaluronan Binds to Heparanase and Blocks Its Enzymatic and Cellular Actions in Carcinoma Cells.

Jia Shi, Riku Kanoya, Yurina Tani, Sodai Ishikawa, Rino Maeda, Sana Suzuki, Fumiya Kawanami, Naoko Miyagawa, Katsuhiko Takahashi, Teruaki Oku …

International journal of molecular sciences, 23(9), May 2, 2022
Coronin-1 is phosphorylated at Thr-412 by protein kinase Cα in human phagocytic cells.

Teruaki Oku, Yutaka Kaneko, Rie Ishii, Yuki Hitomi, Makoto Tsuiji, Satoshi Toyoshima, Tsutomu Tsuji

Biochemistry and biophysics reports, 27 101041-101041, Sep, 2021 Peer-reviewedInvitedLead authorCorresponding author
Effects of sterol derivatives in cationic liposomes on biodistribution and gene-knockdown in the lungs of mice systemically injected with siRNA lipoplexes.

Yoshiyuki Hattori, Hiromu Saito, Teruaki Oku, Kei-Ichi Ozaki

Molecular medicine reports, 24(2), Aug, 2021 Peer-reviewed
Immunomodulatory Activity of an Aqueous Extract of Mycelium of an Endophytic-Like Fungus, Ustilago esculenta

Makoto Tsuiji, Junko Nagasaka, Yoshimasa Yajima, Keita Nishiumi, Yasutaka Kojima, Miho Amemiya, Wakana Ogura, Takaaki Moriyama, Tomoko Sakai, Teruaki Oku …

BPB Reports, 4(4) 98-102, Jul, 2021 Peer-reviewed
Chondroitin sulfate E blocks enzymatic action of heparanase and heparanase-induced cellular responses.

Nobuaki Higashi, Rino Maeda, Nakaba Sesoko, Momoko Isono, Sodai Ishikawa, Yurina Tani, Katsuhiko Takahashi, Teruaki Oku, Kyohei Higashi, Shoichi Onishi …

Biochemical and biophysical research communications, 520(1) 152-158, Nov 26, 2019 Peer-reviewed
Stereoisomer-Specific Induction of G2/M Phase Arrest and Apoptosis by 9-(E,Z)-Hydroxyoctadecadienoic Acid in Mouse Lymphoma Cells.

Atsushi Kodaka, Yuki Hayakawa, Rawaa Jaffar AlSayegh, Tadashi Yasuhara, Hiroshi Tomoda, Teruaki Oku, Shingo Dan, Makoto Tsuiji, Tsutomu Tsuji

Biological & pharmaceutical bulletin, 42(6) 937-943, 2019 Peer-reviewed
Selective Cytotoxicity of Staphylococcal α-Hemolysin (α-Toxin) against Human Leukocyte Populations.

Makoto Tsuiji, Kazuyuki Shiohara, Yoshinori Takei, Yoshinori Shinohara, Shigeyoshi Nemoto, Satoshi Yamaguchi, Masanori Kanto, Saotomo Itoh, Teruaki Oku, Masahiro Miyashita …

Biological & pharmaceutical bulletin, 42(6) 982-988, 2019 Peer-reviewed
Identification of human plasma C1 inhibitor as a target protein for staphylococcal superantigen-like protein 5 (SSL5).

Oku T, Kurisaka C, Ando Y, Tsuji T

Biochemical and biophysical research communications, 508(4) 1162-1167, Jan, 2019 Peer-reviewedLead authorCorresponding author
Stimulation of Peritoneal Mesothelial Cells to Secrete Matrix Metalloproteinase-9 (MMP-9) by TNF-α: A Role in the Invasion of Gastric Carcinoma Cells.

Oku T, Shimada K, Kenmotsu H, Ando Y, Kurisaka C, Sano R, Tsuiji M, Hasegawa S, Fukui T, Tsuji T

International journal of molecular sciences, 19(12), Dec, 2018 Peer-reviewedLead author
Generation of a Monoclonal Antibody Against Staphylococcal Superantigen-Like Protein 5 (SSL5) That Discriminates SSL5 from Other SSL Proteins.

Oku T, Soma H, Kurisaka C, Tsuji T

Monoclon Antib Immunodiagn Immunother, 37(5) 212-217, Nov, 2018 Peer-reviewed
BCGワクチンに代わる結核ワクチンの開発を目指して

奥輝明

ファルマシア, 54(9) 904-904, Sep, 2018 Peer-reviewed
Incorporation, intracellular trafficking and processing of extracellular heparanase by mast cells: Involvement of syndecan-4-dependent pathway.

Higashi N, Waki M, Sudo Y, Suzuki S, Oku T, Tsuiji M, Tsuji T, Miyagishi M, Takahashi K, Nakajima M …

Biochemical and biophysical research communications, 503(4) 3235-3241, Sep, 2018
Role of sialic acid-containing glycans of matrix metalloproteinase-9 (MMP-9) in the interaction between MMP-9 and staphylococcal superantigen-like protein 5

Chisato Kurisaka, Teruaki Oku, Saotomo Itoh, Tsutomu Tsuji

Microbiology and Immunology, 62(3) 168-175, Mar 1, 2018 Peer-reviewed
Platelet Supernatant Suppresses LPS-Induced Nitric Oxide Production from Macrophages Accompanied by Inhibition of NF-kappa B Signaling and Increased Arginase-1 Expression

Yusuke Ando, Teruaki Oku, Tsutomu Tsuji

PLOS ONE, 11(9) e0162208, Sep, 2016 Peer-reviewed
Development of Splice Variant-Specific Monoclonal Antibodies Against Human α3 Integrin

Teruaki Oku, Yusuke Ando, Masaharu Ogura, Tsutomu Tsuji

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 35(1) 12-17, Feb 1, 2016 Peer-reviewed
Platelets attenuate production of cytokines and nitric oxide by macrophages in response to bacterial endotoxin

Yusuke Ando, Teruaki Oku, Tsutomu Tsuji

PLATELETS, 27(4) 344-350, 2016 Peer-reviewed
Thr-412 of coronin-1 is phosphorylated by protein kinase Cα.

Oku T, Kaneko Y, Ishii R, Toyoshima S, Tsuji T

FASEB J, 28 802.23, 2014

Misc.

110

Methylation synthetic lethality: CHFR methylation and KRAS inhibition in gastric cancers

Hideyuki Takeshima, Takahiro Ebata, Yumi Furuichi, Yui Ohashi, Teruaki Oku, Satoshi Yamashita, Toshikazu Ushijima

第46回日本分子生物学会年会, Dec, 2023
Next generation pyrogen testing method developed for rapid, ELISA free and variety of pyrogen detection

Tomohisa Nanao, Yuki Marutani, Tomohiro Mori, Katsuko Sato, Teruaki Oku, Takahiro Nishibu

11th PharmaLab Congress, Nov, 2023
ES細胞のエピゲノム複製に関与するヒストンリーダーの同定

服部奈緒子, Yu-Yu Liu, 奥輝明, 小泉美帆, 本田浩章, 牛島俊和

第96回日本生化学会大会, Oct, 2023
ヒト乳がん細胞MDA-MB-231に対するモノクローナル抗体を用いた抗体依存性細胞貪食活性の解析

小林莉子, 細川航平, 里史明, 加藤良規, 奥輝明

第96回日本生化学会大会, Oct, 2023
分泌型ルシフェラーゼを利用した単球活性化試験法の開発

奥輝明, 七尾友久, 菊池裕

第96回日本生化学会大会, Oct, 2023
Next generation pyrogen testing method developed for rapid, ELISA free and variety of pyrogen detection

Yuki Marutani, Tomohisa Nanao, Tomohiro Mori, Katsuko Sato, Teruaki Oku, Takahiro Nishibu

2023 PDA Pharmaceutical Microbiology Conference, Oct, 2023
ヘパラナーゼによる結腸癌細胞のNF-κBシグナル伝達経路の活性化

史佳, 高橋勝彦, 奥輝明, 中島元夫, 入村達郎, 東信昭

第23回Pharmaco-Hematologyシンポジウム, Jul, 2023
ヒト乳がん細胞MDA-MB-231に対するモノクローナル抗体を用いた抗体依存性細胞貪食活性の解析

小林莉子, 里史明, 築地信, 加藤良規, 奥輝明

第23回Pharmaco-Hematologyシンポジウム, Jul, 2023
硫酸化ヒアルロン酸によるヘパラナーゼ阻害作用の構造的基盤

東伸昭, 史佳, 彼ノ矢陸, 谷祐里菜, 石川壮大, 高橋勝彦, 奥輝明, 山本亜美, 福澤薫, 中島元夫 …

日本薬学会第143年会, Mar, 2023
塩化ナトリウム高濃度状態がマクロファージ様細胞株RAW264.7細胞に及ぼす影響

久保田愛梨、佐藤朋広、佐藤淳之介、奥輝明、築地信

Mar, 2023
抗ヒトTROP2抗体の作製と乳がん細胞株MDA-MB-231に対する細胞傷害活性の解析

川端里奈、小林莉子、築地信、加藤良規、奥輝明

日本薬学会第143年会, Mar, 2023
ヒト乳がん細胞MDA-MB-231に対するモノクローナル抗体を用いた細胞傷害活性の解析

小林莉子, 川端里奈, 里史明, 加藤良規, 築地信, 奥輝明

日本薬学会第143年会, Mar, 2023
マクロファージにおけるCoronin-1発現制御機構の解析

安藤祐介, 金子豊, 長谷川晋也, 築地信, 渡辺知恵, 奥輝明

日本生化学会大会プログラム・講演要旨集, 95回 1P-387, Nov, 2022
ヒト乳がん細胞MDA-MB-231に対する抗体の作製と解析

小林莉子, 川端里奈, 纐纈駿輔, 里史明, 築地信, 加藤良規, 奥輝明

日本生化学会大会プログラム・講演要旨集, 95回 3P-301, Nov, 2022
硫酸化ヒアルロン酸はヘパラナーゼの酵素活性と生物作用を抑制する

東伸昭, 史佳, 彼ノ矢陸, 高橋勝彦, 奥輝明, 福澤薫, 入村達郎, 中島元夫

第41回日本糖質学会年会, Sep, 2022
硫酸化糖鎖によるヘパラナーゼの生物活性の制御

東伸昭, 史佳, 彼ノ矢陸, 高橋勝彦, 奥輝明, 福澤薫, 入村達郎, 中島元夫

第31日本がん転移学会学術集会・総会, Jul, 2022
硫酸化ヒアルロン酸はヘパラナーゼの酵素活性と生物作用を抑制する

東伸昭、史佳、彼ノ矢陸、高橋勝彦、奥輝明、福澤薫、入村達郎、中島元夫

第22回Pharmaco-Hematologyシンポジウム, Jun, 2022
抗TROP2/抗HER3の二重特異性抗体による乳がんの新しい治療薬の開発

河野慧, 余子璋, Sudath, Hapuarachchige, 奥輝明, 岩崎雄介, 加藤良規

第38回日本DDS学会学術集会, Jun, 2022
Development of anti-Trop2-based bispecific antibody for targeted cancer therapy

余子璋, 河野慧, 奥輝明, Sudath Hapuarachchige, 加藤良規

日本薬剤学会第37年会, May, 2022
硫酸化糖鎖によるヘパラナーゼの酵素活性と糖鎖結合活性の制御

東伸昭, 史佳, 彼ノ矢陸, 高橋勝彦, 奥輝明, 福澤薫, 東恭平, 入村達郎, 中島元夫

第6回糖鎖免疫研究会, Mar, 2022

Research Projects

黄色ブドウ球菌免疫回避タンパク質SSL11によるマスト細胞の機能制御機構の解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

奥輝明
Mast cell function is altered by Staphyloccocal superantigen-like protein 11

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Oku Teruaki
Protection against endotoxin shock though stabilization of macrophages by platelet-derived factors

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Tsuji Tsutomu
Analysis of intracellular parasitic mechanism of mycobacteria

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2016 - 2017

Oku Teruaki, ANDO Yusuke, KANEKO Yutaka, NAMIKI Toshikazu, HIRAI Satoshi
Suppression of host defense system by bacterial "cell adhesion-perturbing proteins"

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2014 - 2015

Tsuji Tsutomu, TSUIJI Makoto, OKU Teruaki
Molecular analysis of immune evasion mechanisms by mycobacteria

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2013 - 2014

OKU Teruaki
Modulation by cytokines of integrin-dependent cancer cell adhesion/invasion to peritoneum

Grants-in-Aid for Scientific Research(基盤研究(C)), 基盤研究(C), Ministry of Education, Culture, Sports, Science and Technology, 2011 - 2013

Tsutomu TSUJI, Makoto TSUIJI, Teruaki OKU
The integrin-matrix interaction in the metastasis and invasion processes of cancer

Grants-in-Aid for Scientific Research(基盤研究(C)), 基盤研究(C), Ministry of Education, Culture, Sports, Science and Technology, 2007 - 2008

Tsutomu TSUJI, Saotomo ITOH, Teruaki OKU, Yuta SAITO, Hiromi MIZUNO, Wakana SEKINE, Toshie GOTOU, Kentaro SHIMADA, Go KAMOSHIDA

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