白崎尚芳 (Takayoshi Shirasaki) - マイポータル

基本情報

所属: ノースカロライナ大学チャペルヒル校

J-GLOBAL ID: 201801000929195661
researchmap会員ID: B000317751

研究分野

ライフサイエンス / ウイルス学 /

論文

Wnt/β-Catenin Signaling Regulates Hepatitis B Virus cccDNA Levels.

Atsuya Ishida, Sadahiro Iwabuchi, Ying-Yi Li, Kazuhisa Murai, Takayoshi Shirasaki, Kazuyuki Kuroki, Tetsuro Shimakami, Koki Nio, Kazunori Kawaguchi, Tadashi Imafuku …

International journal of molecular sciences 26(14) 2025年7月19日
Endothelial lipase-binding peptides similar to netrin-1 inhibit hepatitis B virus infection.

Mayuko Ide, Noriko Tabata, Kazuhisa Murai, Yuko Yonemura, Ying Wang, Atsuya Ishida, Takayoshi Shirasaki, Shuichi Kaneko, Satoru Ito, Masao Honda …

FEBS letters 2025年1月25日
Hepatovirus translation requires PDGFA-associated protein 1, an eIF4E-binding protein regulating endoplasmic reticulum stress responses.

Takayoshi Shirasaki, Erik Lenarcic, Ichiro Misumi, Ling Xie, William G Fusco, Bryan Yonish, Anshuman Das, Hyejeong Kim, Craig E Cameron, Mélissa Léger-Abraham …

Science advances 10(47) eadq6342 2024年11月22日
Potential utility of l-carnitine for preventing liver tumors derived from metabolic dysfunction-associated steatohepatitis.

Junyan Lyu, Hikari Okada, Hajime Sunagozaka, Kazunori Kawaguchi, Tetsuro Shimakami, Kouki Nio, Kazuhisa Murai, Takayoshi Shirasaki, Mika Yoshida, Kuniaki Arai …

Hepatology communications 8(5) 2024年5月1日
Nucleos(t)ide analogs for hepatitis B virus infection differentially regulate the growth factor signaling in hepatocytes

Ryogo Shimizu, Kazuhisa Murai, Kensuke Tanaka, Yuga Sato, Naho Takeda, Saki Nakasyo, Takayoshi Shirasaki, Kazunori Kawaguchi, Tetsuro Shimakami, Kouki Nio …

Hepatology Communications 8(1) 2024年1月
Hepatoviruses promote very-long-chain fatty acid and sphingolipid synthesis for viral RNA replication and quasi-enveloped virus release.

Tomoyuki Shiota, Zhucui Li, Guan-Yuan Chen, Kevin L McKnight, Takayoshi Shirasaki, Bryan Yonish, Heyjeong Kim, Ethan J Fritch, Timothy P Sheahan, Masamichi Muramatsu …

Science advances 9(42) eadj4198 2023年10月20日
Met receptor is essential for MAVS-mediated antiviral innate immunity in epithelial cells independent of its kinase activity.

Ryu Imamura, Hiroki Sato, Dominic Chih-Cheng Voon, Takayoshi Shirasaki, Masao Honda, Makoto Kurachi, Katsuya Sakai, Kunio Matsumoto

Proceedings of the National Academy of Sciences of the United States of America 120(40) e2307318120 2023年10月3日
Functional involvement of endothelial lipase in hepatitis B virus infection.

Takayoshi Shirasaki, Kazuhisa Murai, Atsuya Ishida, Kazuyuki Kuroki, Kazunori Kawaguchi, Ying Wang, Souma Yamanaka, Rio Yasukawa, Narumi Kawasaki, Ying-Yi Li …

Hepatology communications 7(9) 2023年9月1日
Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria.

Jérémie Rosain, Anna-Lena Neehus, Jérémy Manry, Rui Yang, Jérémie Le Pen, Wassim Daher, Zhiyong Liu, Yi-Hao Chan, Natalia Tahuil, Özden Türel …

Cell 186(3) 621-645 2023年2月2日
Viral protease cleavage of MAVS in genetically modified mice with hepatitis A virus infection.

Lu Sun, Hui Feng, Ichiro Misumi, Takayoshi Shirasaki, Lucinda Hensley, Olga González-López, Itoe Shiota, Wei-Chun Chou, Jenny P-Y Ting, John M Cullen …

Journal of hepatology 78(2) 271-280 2023年2月
Nonlytic Quasi-Enveloped Hepatovirus Release Is Facilitated by pX Protein Interaction with the E3 Ubiquitin Ligase ITCH.

Takayoshi Shirasaki, Olga González-López, Kevin L McKnight, Ling Xie, Tomoyuki Shiota, Xian Chen, Hui Feng, Stanley M Lemon

Journal of virology 96(21) e0119522 2022年11月9日
Hepatitis B virus utilizes a retrograde trafficking route via the trans-Golgi network to avoid lysosomal degradation.

Ying-Yi Li, Kazuyuki Kuroki, Tetsuro Shimakami, Kazuhisa Murai, Kazunori Kawaguchi, Takayoshi Shirasaki, Kouki Nio, Saiho Sugimoto, Tomoki Nishikawa, Hikari Okada …

Cellular and molecular gastroenterology and hepatology 15(3) 533-558 2022年10月18日
Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX.

Takayoshi Shirasaki, Hui Feng, Helen M E Duyvesteyn, William G Fusco, Kevin L McKnight, Ling Xie, Mark Boyce, Sathish Kumar, Rina Barouch-Bentov, Olga González-López …

PLoS pathogens 18(8) e1010543 2022年8月
The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis.

You Li, Ichiro Misumi, Tomoyuki Shiota, Lu Sun, Erik M Lenarcic, Hyejeong Kim, Takayoshi Shirasaki, Adriana Hertel-Wulff, Taylor Tibbs, Joseph E Mitchell …

Proceedings of the National Academy of Sciences of the United States of America 119(28) e2204511119 2022年7月12日
A single hepatitis B virus genome with a reporter allows the entire viral life cycle to be monitored in primary human hepatocytes.

Ariunaa Sumiyadorj, Kazuhisa Murai, Tetsuro Shimakami, Kazuyuki Kuroki, Tomoki Nishikawa, Masaki Kakuya, Atsumu Yamada, Ying Wang, Atsuya Ishida, Takayoshi Shirasaki …

Hepatology communications 6(9) 2441-2454 2022年6月12日
Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET.

Takayoshi Shirasaki, Satoshi Yamagoe, Tetsuro Shimakami, Kazuhisa Murai, Ryu Imamura, Kiyo-Aki Ishii, Hiroaki Takayama, Yukako Matsumoto, Natsumi Tajima-Shirasaki, Naoto Nagata …

Nature communications 13(1) 3176-3176 2022年6月8日
Guanine nucleotide exchange factor DOCK11-binding peptide fused with a single chain antibody inhibits Hepatitis B Virus infection and replication.

Mayuko Ide, Noriko Tabata, Yuko Yonemura, Takayoshi Shirasaki, Kazuhisa Murai, Ying Wang, Atsuya Ishida, Hikari Okada, Masao Honda, Shuichi Kaneko …

The Journal of biological chemistry 298(7) 102097-102097 2022年6月2日
Forkhead box protein O1 (FoxO1) knockdown accelerates the eicosapentaenoic acid (EPA)-mediated Selenop downregulation independently of sterol regulatory element-binding protein-1c (SREBP-1c) in H4IIEC3 hepatocytes.

Kyoko Kamoshita, Natsumi Tajima-Shirasaki, Kiyo-Aki Ishii, Takayoshi Shirasaki, Hiroaki Takayama, Halimulati Abuduwaili, Tuerdiguli Abuduyimiti, Hein Ko Oo, Xingyu Yao, Qifang Li …

Endocrine journal 69(8) 907-918 2022年3月23日
Establishment of liver tumor cell lines from atherogenic and high fat diet fed hepatitis C virus transgenic mice.

Takayoshi Shirasaki, Kazuhisa Murai, Masao Honda, Hikari Okada, Yuika Innami, Atsumu Yamada, Tetsuro Shimakami, Kazunori Kawaguchi, Taro Yamashita, Yoshio Sakai …

Scientific reports 11(1) 13021-13021 2021年6月22日
DOCK11 and DENND2A play pivotal roles in the maintenance of hepatitis B virus in host cells.

Shinichi Hashimoto, Takayoshi Shirasaki, Taro Yamashita, Sadahiro Iwabuchi, Yutaka Suzuki, Yuzuru Takamura, Yoshiaki Ukita, Shungo Deshimaru, Toshitugu Okayama, Kazuho Ikeo …

PloS one 16(2) e0246313 2021年

もっとみる

MISC

IDENTIFICATION OF A HOST FACTOR FOR THE IMPROVEMENT OF IMMUNE CHECKPOINT BLOCKADE THERAPY FOR HEPATOCELLULAR CARCINOMA

Kazuhisa Murai, Masao Honda, Takayoshi Shirasaki, Shuichi Kaneko

HEPATOLOGY 70 808A-809A 2019年10月
A LIVER-DERIVED SECRETORY PROTEIN, LECT2, RESTORES THE IMPAIRED PLASMACYTOIDDENDRITIC CELLS FUNCTION BY HBV AND PROTECTS HEPATOCYTES AGAINST HBV INFECTION

Souma Yamanaka, Masao Honda, Takayoshi Shirasaki, Tetsuro Shimakami, Ryosuke Shimizu, Kazuhisa Murai, Miwako Narita, Hirofumi Misu, Toshinari Takamura, Taro Yamashita …

HEPATOLOGY 70 616A-617A 2019年10月
A Liver-Derived Secretory Protein, LECT2, Enhances the Innate Immune Response and Suppresses RIG-I Mediated Virus Infection

Takayoshi Shirasaki, Masao Honda, Kazuhisa Murai, Tetsuro Shimakami, Hirofumi Misu, Toshinari Takamura, Shuichi Kaneko

HEPATOLOGY 68 588A-589A 2018年10月
mRNA for selenoprotein P, a hepatokine, binds RIG-I protein and inhibits the RIG-I-mediated type I interferon response

Kazuhisa Murai, Masao Honda, Tetsuro Shimakami, Takayoshi Shirasaki, Hirofumi Misu, Toshinari Takamura, Shuichi Kaneko

CYTOKINE 100 76-76 2017年12月
IFN-lambda 3 induces dendritic cell maturation independently of type I IFN

Kazuhisa Murai, Masao Honda, Tetsuro Shimakami, Takayoshi Shirasaki, Shiho Tanaka, Shuichi Kaneko

CYTOKINE 100 117-117 2017年12月
A liver-derived secretory protein, LECT2, enhances the innate immune response and suppresses HCV replication

Takayoshi Shirasaki, Masao Honda, Kazuhisa Murai, Tetsuro Shimakami, Hirofumi Misu, Toshinari Takarnura, Shuichi Kaneko

CYTOKINE 100 117-117 2017年12月
MicroRNA-10a is associated with the impaired liver functions in patients with advanced stage of chronic hepatitis C

Rika Horii, Masao Honda, Takayoshi Shirasaki, Tetsuro Shimakami, Shuichi Kaneko

HEPATOLOGY 66 461A-461A 2017年10月
mRNA for selenoprotein P, a hepatokine, binds RIG-I protein and inhibits the RIG-I-mediated type I interferon response

Kazuhisa Murai, Masao Honda, Tetsuro Shimakami, Takayoshi Shirasaki, Hirofumi Misu, Toshinari Takamura, Seishi Murakami, Shuichi Kaneko

HEPATOLOGY 66 460A-460A 2017年10月
Intracellular HBV degradation is associated with Notch signaling inhibition via ITCH in a ubiquitin proteasome-dependent manner

Zijing Wang, Kazunori Kawaguchi, Masao Honda, Hikari Okada, Takayoshi Shirasaki, Tetsuro Shimakami, Shuichi Kaneko

HEPATOLOGY 66 794A-795A 2017年10月
Inhibitory effect of acyclic retinoid on hepatitis B virus replication

Ryogo Shimizu, Masao Honda, Takayoshi Shirasaki, Tetsuro Shimakami, Kazuhisa Murai, Shuichi Kaneko

HEPATOLOGY 66 791A-792A 2017年10月
IFN-lambda 3 induces dendritic cell maturation independently of type I IFN

Shiho Tanaka, Masao Honda, Kazuhisa Murai, Tetsuro Shimakami, Takayoshi Shirasaki, Seishi Murakami, Shuichi Kaneko

HEPATOLOGY 66 476A-477A 2017年10月
Osteopontin regulates IFN signaling and HCV replication in cancer stem cells

Ryogo Shimizu, Masao Honda, Takayoshi Shirasaki, Tetsuro Shimakami, Taro Yamashita, Shuichi Kaneko

HEPATOLOGY 66 463A-464A 2017年10月
A liver-derived secretory protein, LECT2, activates plasmacytoid dendritic cells and protects hepatocytes from HBV infection

Takayoshi Shirasaki, Masao Honda, Kazuhisa Murai, Tetsuro Shimakami, Miwako Narita, Hirofumi Misu, Toshinari Takamura, Seishi Murakami, Shuichi Kaneko

HEPATOLOGY 66 802A-802A 2017年10月
Regulation of Hepatitis C Virus Infection by Long Non-Coding RNA

Juria Kitabayashi, Tetsuro Shimakami, Takayoshi Shirasaki, Kazuhisa Murai, Masao Honda, Shuichi Kaneko

HEPATOLOGY 66 473A-473A 2017年10月
Unexpected Enhancement of Replication Capacity by Simeprevir for Simeprevir-Resistant Variants in Genotype 1a Hepatitis C Virus

Tetsuro Shimakami, Kazuhisa Murai, Christoph Welsch, Takayoshi Shirasaki, Masao Honda, Shuichi Kaneko

HEPATOLOGY 66 578A-578A 2017年10月
Nucleos(t)ide analogues and interferon affect intranuclear HBV genome in vitro via Notch signaling modification, independent of the ubiquitin-proteasome system

Kazunori Kawaguchi, Zijing Wang, Masao Honda, Takayoshi Shirasaki, Hikari Okada, Tetsuro Shimakami, Kouki Nio, Taro Yamashita, Yoshio Sakai, Eishiro Mizukoshi …

HEPATOLOGY 66 798A-799A 2017年10月
IFN lambda 3 enhances poly(I:C)-induced type-I IFN induction and DC maturation

Yuika Innami, Masao Honda, Kazuhisa Murai, Tetsuro Shimakami, Takayoshi Shirasaki, Seishi Murakami, Shuichi Kaneko

HEPATOLOGY 64 526A-527A 2016年10月
A liver-derived secretory protein, LECT2, enhances the innate immune response and suppresses HCV replication

Takayoshi Shirasaki, Masao Honda, Kazuhisa Murai, Tetsuro Shimakami, Hirofumi Misu, Toshinari Takamura, Seishi Murakami, Shuichi Kaneko

HEPATOLOGY 64 738A-739A 2016年10月
Effective Prevention of Direct-acting Antiviral-resistant Hepatitis C Virus by Combination with Anti-miR-122 Therapy in Cell Culture

Tetsuro Shimakami, Fanwei Liu, Kazuhisa Murai, Takayoshi Shirasaki, Masao Honda, Shuichi Kaneko

HEPATOLOGY 64 729A-729A 2016年10月
Selenoprotein P, a liver-derived secretory protein, regulates RIG-I-mediated innate immunity in hepatocytes

Kazuhisa Murai, Masao Honda, Tetsuro Shimakami, Takayoshi Shirasaki, Hirofumi Misu, Toshinari Takamura, Stanley M. Lemon, Seishi Murakami, Shuichi Kaneko

HEPATOLOGY 64 730A-731A 2016年10月

もっとみる

共同研究・競争的資金等の研究課題

肝疾患におけるIFNλ4の機能的役割の解明

日本学術振興会科学研究費助成事業若手研究(B) 若手研究(B) 2016年4月 - 2019年3月

白崎尚芳
包括的１細胞遺伝子発現解析を用いたB型肝炎ウイルス感染機構の解明

日本学術振興会科学研究費助成事業挑戦的萌芽研究挑戦的萌芽研究 2016年4月 - 2017年3月

本多政夫, 白崎尚芳, 川口和紀, 大石尚毅, 橋本真一
肝炎ウイルス複製を支持する新規肝癌由来培養細胞の樹立

日本学術振興会科学研究費助成事業挑戦的萌芽研究挑戦的萌芽研究 2014年4月 - 2016年3月

本多政夫, 山下太郎, 島上哲朗, 白崎尚芳
C型慢性肝炎に対するIFN応答・不応答メカニズムの解明

日本学術振興会科学研究費助成事業若手研究(B) 若手研究(B) 2013年4月 - 2016年3月

白崎尚芳

産業財産権

特許第6986263号抗ウイルス薬

橋本真一, 金子周一, 本多政夫, 白崎尚芳, 山下太郎
特許第6948685号抗癌作用増強剤及び癌治療支援方法

金子周一, 本多政夫, 白崎尚芳
特開2018-070563 抗癌作用増強剤及び癌治療支援方法

金子周一, 本多政夫, 白崎尚芳
WO2017-082202 抗ウイルス薬

橋本真一, 金子周一, 本多政夫, 白崎尚芳, 山下太郎

白崎尚芳

基本情報

研究分野

論文

MISC

共同研究・競争的資金等の研究課題

産業財産権

メニュー

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