2015年
Biodegradable PLGA nanoparticles loaded with hydrophobic drugs: confocal Raman microspectroscopic characterization
JOURNAL OF MATERIALS CHEMISTRY B
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- 巻
- 3
- 号
- 18
- 開始ページ
- 3677
- 終了ページ
- 3680
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1039/c5tb00434a
- 出版者・発行元
- ROYAL SOC CHEMISTRY
Poly(lactic-co-glycolic acid) (PLGA) nanoparticles with bicyclol (5%) and 3-n-butyl-6-bromophthalid (Br-NBP) (3%) were prepared by an emulsification-solvent evaporation technique. The PLGA nanoparticles were, for the first time, successfully characterized by a laser trapping/confocal Raman spectroscopic technique using only individual PLGA nanoparticles. This technique allowed us to selectively obtain Raman spectra of optically trapped PLGA nanoparticles (similar to 10 nanoparticles) in solution. The Raman spectra of the PLGA nanoparticles loaded with hydrophobic drugs showed that these drugs were incorporated in the nanoparticles.
- リンク情報
- ID情報
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- DOI : 10.1039/c5tb00434a
- ISSN : 2050-750X
- eISSN : 2050-7518
- ORCIDのPut Code : 31460831
- Web of Science ID : WOS:000353656400002