Phylogeny of extant mammals have been dramatically modified by the application of molecular genetics, and correlation of the new phylogeny and biogeography has been suggested; however, extinct mammals, such as Creodonta, are excluded from such discussion. We determined classification of hyaenodontid creodonts from the Paleogene of Asia and reviewed occurrences of each hyaenodontid lineages. The results suggested that there were several dispersal events between Asia and other continents, including immigration from Africa in the early Eocene and multiple immigration and/or emigration in mid-to-high latitude northern hemisphere in the Eocene and Oligocene. Morphological observations and paleobiogeographical evidences indicated differences between hyaenodontid creodonts and carnivorans, which has been treated as the sister group of creodonts.