Hirokazu Miki - My portal

Profile Information

Affiliation: 輸血・細胞治療部, 徳島大学病院

J-GLOBAL ID: 201901001033762161
researchmap Member ID: B000378557

Awards

Jun, 2017

ANZBMS Plenary Poster Award., Osteoclasts utilize TRAIL for their NF-B activation, but TAK1 inhibition resumes TRAIL-induced apoptosis in osteoclasts., Australian and New Zealand Bone and Mineral Society

Hirofumi Tenshin, Jumpei Teramachi, A Oda, Ryota Amachi, Masahiro Hiasa, A Baterdene, Keiichiro Watanabe, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto, Masahiro Abe
Jul, 2016

第34回日本骨代謝学会学術集会・第3回アジア太平洋骨代謝学会議,Young investigator award., 破骨細胞はTAK1の発現誘導を介しアポトーシスを抑制しTRAILにより成熟活性化される, Japanese Society for Bone and Mineral Research

Hirofumi Tenshin, Jumpei Teramachi, 小田明日香, Ryota Amachi, Masahiro Hiasa, Keiichiro Watanabe, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto, Masahiro Abe
Oct, 2013

Plenary poster & Young Investigator Travel Award, 5. Potent induction of bone formation in myeloma bone lesions by the cathepsin K inhibitor KK1-300-01 in combinat ion with the proteasome inhibitor bortezomib., The American Society for Bone and Mineral Research

Keiichiro Watanabe, Masahiro Abe, H Mori, R Amachi, Masahiro Hiasa, T Harada, Shiroh Fujii, Shingen Nakamura, Hirokazu Miki, Kumiko Kagawa, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto

Papers

PD-L1 upregulation in myeloma cells by panobinostat in combination with interferon-γ.

Masami Iwasa, Takeshi Harada, Asuka Oda, Ariunzaya Bat-Erdene, Jumpei Teramachi, Hirofumi Tenshin, Mohannad Ashtar, Masahiro Oura, Kimiko Sogabe, Kengo Udaka …

Oncotarget, 10(20) 1903-1917, Mar 8, 2019 Peer-reviewed
Lambda Light Chain Non-crystalline Proximal Tubulopathy with IgD Lambda Myeloma.

Seiji Kishi, Fumiaki Obata, Hirokazu Miki, Motokazu Matsuura, Kenji Nishimura, Masanori Tamaki, Fumi Kishi, Taichi Murakami, Hideharu Abe, Kojiro Nagai …

Internal medicine (Tokyo, Japan), 57(24) 3597-3602, Dec 15, 2018 Peer-reviewed
不明熱と著明な高CRP血症で発症したde novo CD20陰性びまん性大細胞型B細胞リンパ腫の1例

Yuko Miyakami, Shingen Nakamura, Masahiro Oura, Yasunobu Okamoto, 高橋真美子, Kimiko Sogabe, 岩佐昌美, Takeshi Harada, Shiroh Fujii, Hirokazu Miki …

Shikoku Acta Medica, Vol.74(No.5-6) 193-200, Dec, 2018 Peer-reviewed
Cryptosporidiosis in a transplant recipient with severe intractable diarrhea: Detection of Cryptosporidium oocysts by intestinal biopsies

Kumiko Kagawa, Hikaru Fujino, Hirokazu Miki, Kimiko Sogabe, Mamiko Takahashi, Tomoko Maruhashi, Kengo Udaka, Masami Iwasa, Shiro Fujii, Shingen Nakamura …

Transplant Infectious Disease, 20(2) e12826-e12826, Apr 1, 2018 Peer-reviewed
Effective impairment of myeloma cells and their progenitors by hyperthermia.

Hirokazu Miki, Shingen Nakamura, Asuka Oda, Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Ariunzaya Bat-Erdene, Yusaku Maeda, Masahiro Oura, Mamiko Takahashi …

Oncotarget, 9(12) 10307-10316, Feb 13, 2018 Peer-reviewed
Pim-2 is a critical target for treatment of osteoclastogenesis enhanced in myeloma.

Jumpei Teramachi, Masahiro Hiasa, Asuka Oda, Takeshi Harada, Shingen Nakamura, Ryota Amachi, Hirofumi Tenshin, Masami Iwasa, Shiro Fujii, Kumiko Kagawa …

British journal of haematology, 180(4) 581-585, Feb, 2018 Peer-reviewed
TAK1 inhibition subverts the osteoclastogenic action of TRAIL while potentiating its antimyeloma effects.

Hirofumi Tenshin, Jumpei Teramachi, Asuka Oda, Ryota Amachi, Masahiro Hiasa, Ariunzaya Bat-Erdene, Keiichiro Watanabe, Masami Iwasa, Takeshi Harada, Shiro Fujii …

Blood advances, 1(24) 2124-2137, Nov 14, 2017 Peer-reviewed
Memory B cell resurgence requires repeated rituximab in myasthenia gravis

Kohei Muto, Naoko Matsui, Yuki Unai, Waka Sakai, Shotaro Haji, Kengo Udaka, Hirokazu Miki, Takahiro Furukawa, Masahiro Abe, Ryuji Kaji

Neuromuscular Disorders, 27(10) 918-922, Oct 1, 2017 Peer-reviewed
Expansion of Th 1 -like Vγ 9 Vδ 2 T cells by new-generation IMiDs, lenalidomide and pomalidomide, in combination with zoledronic acid

T. Harada, H. Miki, Q. Cui, A. Oda, R. Amachi, J. Teramachi, A. Bat-Erdene, K. Sogabe, M. Iwasa, S. Fujii …

Leukemia, 31(1) 258-262, Jan 1, 2017 Peer-reviewed
Synergistic targeting of Sp1, a critical transcription factor for myeloma cell growth and survival, by panobinostat and proteasome inhibitors.

Ariunzaya Bat-Erdene, Hirokazu Miki, Asuko Oda, Shingen Nakamura, Jumpei Teramachi, Ryota Amachi, Hirofumi Tenshin, Masahiro Hiasa, Masami Iwasa, Takeshi Harada …

Oncotarget, Vol.7(No.48) 79064-79075, Nov 29, 2016 Peer-reviewed
A vicious cycle between acid sensing and survival signaling in myeloma cells: acid-induced epigenetic alteration

Ryota Amachi, Masahiro Hiasa, Jumpei Teramachi, Takeshi Harada, Asuka Oda, Shingen Nakamura, Derek Hanson, Keiichiro Watanabe, Shiro Fujii, Hirokazu Miki …

ONCOTARGET, 7(43) 70447-70461, Oct, 2016 Peer-reviewed
Susceptibility to bendamustine considerably varies among myeloma cells, but is enhanced in acidic conditions

Shingen Nakamura, Hirokazu Miki, Asuka Oda, Ryota Amachi, Jumpei Teramachi, Kimiko Sogabe, Hikaru Fujino, Tomoko Maruhashi, Shiroh Fujii, Kumiko Kagawa …

International Journal of Myeloma, Vol.6(No.1) 7-11, Oct, 2015 Peer-reviewed
Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation

Derek James Hanson, Shingen Nakamura, Ryota Amachi, Masahiro Hiasa, Asuka Oda, Daisuke Tsuji, Kohji Itoh, Takeshi Harada, Kazuki Horikawa, Jumpei Teramachi …

ONCOTARGET, 6(32) 33568-33586, Oct, 2015 Peer-reviewed
Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma

M. Hiasa, J. Teramachi, A. Oda, R. Amachi, T. Harada, S. Nakamura, H. Miki, S. Fujii, K. Kagawa, K. Watanabe …

Leukemia, 29(1) 207-217, Jan 10, 2015 Peer-reviewed
Induction of endoplasmic reticulum stress by bortezomib sensitizes myeloma cells to DR5-mediated cell death

Hirokazu Miki, Shingen Nakamura, A Oda, R Amachi, Keiichiro Watanabe, D Hanson, Jumpei Teramachi, Masahiro Hiasa, H Yagi, K Sogabe …

International Journal of Myeloma., Vol.5(No.1) 1-7, Jan, 2015 Peer-reviewed
Successful treatment of refractory severe aplastic anemia with bone marrow transplantation from a genetically identical twin

Kumiko Kagawa, Shingen Nakamura, Hirokazu Miki, Masahiro Abe

Shikoku Acta Medica, Vol.70(No.3,4) 77-80, Jun, 2014 Peer-reviewed
Photostable iodinated silica/porphyrin hybrid nanoparticles with heavy-atom effect for wide-field photodynamic/photothermal therapy using single light source

Koichiro Hayashi, Michihiro Nakamura, Hirokazu Miki, Shuji Ozaki, Masahiro Abe, Toshio Matsumoto, Toshinari Kori, Kazunori Ishimura

Advanced Functional Materials, 24(4) 503-513, Jan 29, 2014 Peer-reviewed
Magnetically Responsive Smart Nanoparticles for Cancer Treatment with a Combination of Magnetic Hyperthermia and Remote-Control Drug Release

Koichiro Hayashi, Michihiro Nakamura, Hirokazu Miki, Shuji Ozaki, Masahiro Abe, Toshio Matsumoto, Wataru Sakamoto, Toshinobu Yogo, Kazunori Ishimura

THERANOSTICS, 4(8) 834-844, 2014 Peer-reviewed
Activating transcription factor 4, an ER stress mediator, is required for, but excessive ER stress suppresses osteoblastogenesis by bortezomib

Shingen Nakamura, Hirokazu Miki, Shinsuke Kido, Ayako Nakano, Masahiro Hiasa, Asuka Oda, Hiroe Amou, Keiichiro Watanabe, Takeshi Harada, Shiro Fujii …

International Journal of Hematology, 98(1) 66-73, Jul, 2013 Peer-reviewed
Gold Nanoparticle Cluster/Plasmon-Enhanced Fluorescent Silica Core-Shell Nanoparticles for X-Ray Computed Tomography/Fluorescence Dual-Mode Imaging of Tumors

Koichiro Hayashi, Michihiro Nakamura, Hirokazu Miki, Shuji Ozaki, Masahiro Abe, Toshio Matsumoto, Kazunori Ishimura

Chemical Communications, Vol.49 5334-5336, Apr 23, 2013 Peer-reviewed

Books and Other Publications

アミロイド原性light chainの脾臓での産生 ALアミロイドーシス，多発性骨髄腫の類縁疾患

Hirokazu Miki, Masahiro Abe

Iyaku Journal Co., Ltd., Aug 12, 2014
多発性骨髄腫に対する合併症の治療(腎，骨，感染症)

Hirokazu Miki, Masahiro Abe

Oct 20, 2012

Presentations

106

輸血後7日目にIgG抗E抗体を酵素法にて強く検出した一症例

小田直輝, 悦子李, 松本真弓, 高松典道, Hirokazu Miki, Toshio Matsumoto

第45回中四国支部医学検査学会, Oct, 2121
Targeting myeloma metabolisms regulated by HDAC1-IRF4 axis can be a novel therapeutic strategy

Takeshi Harada, Asuka Oda, Hirofumi Tenshin, Jumpei Teramachi, Masahiro Oura, Kimiko Sogabe, Shiroh Fujii, Shingen Nakamura, Hirokazu Miki, Kumiko Kagawa, Shuji Ozaki, Teru Hideshima, C. Kenneth Anderson, Masahiro Abe

17th International Myeloma Workshop, Sep 13, 2019
ゲノムワイド関連解析を用いたテイコプラニン・バンコマイシン投与による皮疹発現および血中濃度関連遺伝子座の同定

Yuto Tanigaki, Yuta Yamaguchi, Naoto Okada, Shingen Nakamura, Kumiko Kagawa, Shiroh Fujii, Hirokazu Miki, Keisuke Ishizawa, Masahiro Abe, Youichi Sato

日本薬学会第139年会, Mar 21, 2019
Peri-implantitis and the role of Febuxostat in osteoclast differentiation.

Mohannad Ashtar, Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Kotaro Tanimoto, Oda Asuka, Iwasa Masami, Takeshi Harada, Bat-Erdene Ariunzaya, Kimiko Sogabe, Masahiro Oura, Shiroh Fujii, Kumiko Kagawa, Shingen Nakamura, Hirokazu Miki, Toshio Matsumoto, Masahiro Abe, Eiji Tanaka

AEEDC Dubai World Orthodontic Conference, Feb 6, 2019
多発小結節影を認めたHIV陽性ニューモシスチス肺炎の1例

Yohsuke Kaneko, Mayo Kondou, Naoki Takahashi, Makoto Tobiume, Hirokazu Ogino, Seidai Satou, Hirokazu Miki, Hisatsugu Goto, Masahiro Abe, Yasuhiko Nishioka

第119回日本内科学会四国地方会, Dec 2, 2018
The critical role of the HDAC1-IRF4-Pim-2 axis in myeloma cell growth and survival: therapeutic impacts of targeting the HDAC1-IRF4-Pim-2 axis

Takeshi Harada, Asuka Oda, Yohann Grondin, Jumpei Teramachi, Ariunzaya Bat-Erdene, Masami Iwasa, Masahiro Oura, Shingen Nakamura, Kumiko Kagawa, Yasunobu Okamoto, Kimiko Sogabe, Shiroh Fujii, Hirokazu Miki, Shuji Ozaki, Teru Hideshima, Kenneth C. Anderson, Masahiro Abe

60th ASH Annual Meeting & Exposition, Dec 1, 2018
Alteration of muscle mass after chemotherapy in patients with newly diagnosed multiple myeloma.

Shingen Nakamura, Hirokazu Miki, Ariunzaya Bat-Erdene, Yasunobu Okamoto, Kimiko Sogabe, Masahiro Oura, Mamiko Takahashi, Masami Iwasa, Takeshi Harada, Shiroh Fujii, Kumiko Kagawa, Masahiro Abe

Esmo asia 2018, Nov 24, 2018
CYP遺伝子多型とバンコマイシンの副作用発現及び血中濃度との関連解析

Yuta Yamaguchi, Yuto Tanigaki, Naoto Okada, Shingen Nakamura, Kumiko Kagawa, Shiroh Fujii, Hirokazu Miki, Keisuke Ishizawa, Masahiro Abe, Youichi Sato

第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov 10, 2018
ゲノムワイド関連解析を用いたビンクリスチンによる末梢神経障害発現関連遺伝子の同定

Rio Ohmori, Naoto Okada, Shingen Nakamura, Kumiko Kagawa, Shiroh Fujii, Hirokazu Miki, Keisuke Ishizawa, Masahiro Abe, Youichi Sato

第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov 10, 2018
Mechanisms of TAK1 over-activation in myeloma cells and TAK1-mediated myeloma growth and bone destruction

Jumpei Teramachi, Hirofumi Tenshin, Masahiro Hiasa, Oda Asuka, Bat-Erdene Ariunzaya, Takeshi Harada, Iwasa Masami, Shiroh Fujii, Kimiko Sogabe, Shingen Nakamura, Hirokazu Miki, Masahiro Oura, Kumiko Kagawa, Itsuro Endo, Toshio Matsumoto, Masahiro Abe

第80回日本血液学会学術集会, Oct 13, 2018
The effects of cathepsin K inhibition on osteocytes: its role in bone restoration in MM bone disease.

Masahiro Hiasa, Jumpei Teramachi, Hirofumi Tenshin, Kotaro Tanimoto, Ariunzaya Bat-Erdene, Mohannad Ashtar, Masami Iwasa, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Kimiko Sogabe, Oura Masahiro, Shiroh Fujii, Kumiko Kagawa, Oda Asuka, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto, Masahiro Abe

The 80th Annual Meeting of the Japanese Society of Hematology, Oct 12, 2018, Japanese Society of Hematology
Impact of denervation-induced paralysis and mechanical unloading on tumor expansion in myeloma.

Kotaro Tanimoto, Masahiro Hiasa, Hirofumi Tenshin, Jumpei Teramachi, Oda Asuka, Mohannad Ashtar, Ariunzaya Bat-Erdene, Iwasa Masami, Kimiko Sogabe, Oura Masahiro, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto, Masahiro Abe

The 80th Annual Meeting of the Japanese Society of Hematology, Oct 12, 2018, Japanese Society of Hematology
Inverse regulation of c-FLIP-mediated survival in myeloma cells and osteoclasts by TRAIL.

Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Kotaro Tanimoto, Mohannad Ashtar, Ariunzaya Bat-Erdene, Iwasa Masami, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Kimiko Sogabe, Oura Masahiro, Shiroh Fujii, Kumiko Kagawa, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto, Masahiro Abe

The 80th Annual Meeting of the Japanese Society of Hematology, Oct 12, 2018, Japanese Society of Hematology
Roles of ROS in induction of bone disease and cancer treatment-induced bone loss in myeloma.

Ashtar Mohannad, Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Kotaro Tanimoto, Oda Asuka, Iwasa Masami, Takeshi Harada, Ariunzaya Erdene Bat, Kimiko Sogabe, Oura Masahiro, Shiroh Fujii, Kumiko Kagawa, Shingen Nakamura, Hirokazu Miki, Eiji Tanaka, Toshio Matsumoto, Masahiro Abe

The 80th Annual Meeting of the Japanese Society of Hematology, Oct 12, 2018, Japanese Society of Hematology
HDAC阻害による骨髄腫細胞のIFN-γ-STAT1- PD-L1経路の増強効果

Masami Iwasa, Takeshi Harada, Bat-Erdene Ariunzaya, 小田明日香, Kimiko Sogabe, Masahiro Oura, Jumpei Teramachi, Shiroh Fujii, Shingen Nakamura, Hirokazu Miki, Kumiko Kagawa, Masahiro Abe

第80回日本血液学会学術集会, Oct 12, 2018
Opposite effects of TRAIL on the Sp-1-c-FLIP survival pathway in myeloma cells and osteoclasts.

Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Oda Asuka, Ashtar Mohannad, Kotaro Tanimoto, Iwasa Masami, Bat-Erdene Ariunzaya, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto, Masahiro Abe

ASBMR 2018 Annual Meeting, Sep 28, 2018, The American Society for Bone and Mineral Research
Disruption of a progressive vicious cycle between myeloma tumor growth and bone destruction by TAK1 inhibition

Jumpei Teramachi, Hirofumi Tenshin, Masahiro Hiasa, Oda Asuka, Bat-Erdene Ariunzaya, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Toshio Matsumoto, Masahiro Abe

ASBMR 2018 Annual Meeting, Sep 28, 2018
Selective inhibition of class-I HDAC induces myeloma cell death through targeting IRF4-Pim-2 axis

Takeshi Harada, Oda Asuka, Jumpei Teramachi, Bat-Erdene Ariunzaya, Iwasa Masami, Oura Masahiro, Shingen Nakamura, Kumiko Kagawa, Okamoto Yasunobu, Kimiko Sogabe, Shiroh Fujii, Hirokazu Miki, Hideshima Teru, Anderson C. Kenneth, Masahiro Abe

The 9th JSH International Symposium 2018 in Kyoto, Jul 27, 2018
TAK1阻害はTRAILによる破骨細胞活性化作用を遮断させると同時にTRAILの抗骨髄腫作用を増強する

Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Kotaro Tanimoto, Mohannad Ashtar, Ariunzaya Bat-Erdene, Masami Iwasa, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto, Masahiro Abe

第36回日本骨代謝学会学術集会, Jul 26, 2018, Japanese Society for Bone and Mineral Research
カテプシンK阻害による多発性骨髄腫骨病変部の骨量回復プロセスにおける骨細胞の役割．

Masahiro Hiasa, Jumpei Teramachi, Hirofumi Tenshin, Kotaro Tanimoto, Mohannad Ashtar, Ariunzaya Bat-Erdene, Masami Iwasa, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto, Masahiro Abe

第36回日本骨代謝学会学術集会, Jul 26, 2018, Japanese Society for Bone and Mineral Research

Research Projects

新規抗骨髄腫薬を用いたTh1様γδT細胞の誘導法とその抗骨髄腫活性の増強法の開発

Grants-in-Aid for Scientific Research, Apr, 2017 - Mar, 2020

三木浩和
Effective expansion of Th1-like gdT cells and anti-myeloma effects

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

MIKI Hirokazu
Targeting myeloma progenitors by ex vivo-expanded gamma delta T cell

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

MIKI Hirokazu