論文

査読有り
2017年11月

Actions of Brain-Derived Neurotrophic Factor and Glucocorticoid Stress in Neurogenesis

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
  • Tadahiro Numakawa
  • ,
  • Haruki Odaka
  • ,
  • Naoki Adachi

18
11
記述言語
英語
掲載種別
DOI
10.3390/ijms18112312
出版者・発行元
MDPI AG

Altered neurogenesis is suggested to be involved in the onset of brain diseases, including mental disorders and neurodegenerative diseases. Neurotrophic factors are well known for their positive effects on the proliferation/differentiation of both embryonic and adult neural stem/progenitor cells (NSCs/NPCs). Especially, brain-derived neurotrophic factor (BDNF) has been extensively investigated because of its roles in the differentiation/maturation of NSCs/NPCs. On the other hand, recent evidence indicates a negative impact of the stress hormone glucocorticoids (GCs) on the cell fate of NSCs/NPCs, which is also related to the pathophysiology of brain diseases, such as depression and autism spectrum disorder. Furthermore, studies including ours have demonstrated functional interactions between neurotrophic factors and GCs in neural events, including neurogenesis. In this review, we show and discuss relationships among the behaviors of NSCs/NPCs, BDNF, and GCs.

Web of Science ® 被引用回数 : 26

リンク情報
DOI
https://doi.org/10.3390/ijms18112312
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29099059
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000416811300085&DestApp=WOS_CPL