Shimazaki, Takuya

J-GLOBAL         Last updated: Aug 24, 2019 at 02:53
 
Avatar
Name
Shimazaki, Takuya
Affiliation
Keio University
Section
School of Medicine Department of Physiology
Job title
Associate Professor
Degree
博士(医学)(東京大学大学院医学系研究科)
Research funding number
00324749

Research Areas

 
 

Published Papers

 
SHIMAZAKI TAKUYA
The Keio Journal of Medicine   65(1) 1-15   Feb 2016   [Refereed][Invited]
SHIMAZAKI TAKUYA
NPJ Aging and Mechanisms of Diseases   2 15014   Jan 2016   [Refereed][Invited]
Tsuyama, Jun,Bunt, Jens, Richards, Linda J, Iwanari, Hiroko, Mochizuki, Yasuhiro, Hamakubo, Takao, Shimazaki, Takuya, Okano, Hideyuki
Stem Cell Reports   5(3) 365-377   Sep 2015   [Refereed]
Tomioka, Takeyasu, Shimazaki, Takuya, Yamauchi, Toshihiko, Oki, Toru, Ohgoh, Makoto, Okano, Hideyuki
JOURNAL OF BIOLOGICAL CHEMISTRY   289(2) 1000-1010   Jan 2014   [Refereed]
Naka-Kaneda, Hayato, Nakamura, Shiho, Igarashi, Mana, Aoi, Hisashi, Kanki, Hiroaki, Tsuyama, Jun, Tsutsumi, Shuichi, Aburatani, Hiroyuki, Shimazaki, Takuya, Okano, Hideyuki
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   111(4) 1604-1609   Jan 2014   [Refereed]
Sato, Takuya, Shimazaki, Takuya, Naka, Hayato, Fukami, Shin-Ichi, Satoh, Yasushi, Okano, Hideyuki, Lax, Irit, Schlessinger, Joseph, Gotoh, Noriko
STEM CELLS   28(9) 1660-1672   Sep 2010   [Refereed]
Sakaguchi, Masanori, Imaizumi, Yoichi, Shingo, Tetsuro, Tada, Hirobumi, Hayama, Ko, Yamada, Osamu, Morishita, Tsuyoshi, Kadoya, Toshihiko, Uchiyama, Noboru, Shimazaki, Takuya, Kuno, Atsushi, Poirier, Francoise, Hirabayashi, Jun, Sawamoto, Kazunobu, Okano, Hideyuki
JOURNAL OF NEUROCHEMISTRY   113(6) 1516-1524   Jun 2010   [Refereed]
Ishii, Seiji, Okada, Yohei, Kadoya, Toshihiko, Matsuzaki, Yumi, Shimazaki, Takuya, Okano, Hideyuki
JOURNAL OF NEUROSCIENCE RESEARCH   88(4) 722-734   Mar 2010   [Refereed]
Tao, Osamu, Shimazaki, Takuya, Okada, Yohei, Naka, Hayato, Kohda, Kazuhisa, Yuzaki, Michisuke, Mizusawa, Hidehiro, Okano, Hideyuki
JOURNAL OF NEUROSCIENCE RESEARCH   88(2) 234-247   Feb 2010   [Refereed]
Ogawa, Daisuke, Okada, Yohei, Nakamura, Masaya, Kanemura, Yonehiro, Okano, Hirotaka James, Matsuzaki, Yumi, Shimazaki, Takuya, Ito, Mamoru, Ikeda, Eiji, Tamiya, Takashi, Nagao, Seigo, Okano, Hideyuki
JOURNAL OF NEUROSCIENCE RESEARCH   87(2) 307-317   Feb 2009   [Refereed]
Naka, Hayato, Nakamura, Shiho, Shimazaki, Takuya, Okano, Hideyuki
NATURE NEUROSCIENCE   11(9) 1014-1023   Sep 2008   [Refereed]
Ozawa, Yoko, Nakao, Keiko, Kurihara, Toshihide, Shimazaki, Takuya, Shimmura, Shigeto, Ishida, Susumu, Yoshimura, Akihiko, Tsubota, Kazuo, Okano, Hideyuki
JOURNAL OF BIOLOGICAL CHEMISTRY   283(36) 24561-24570   Sep 2008   [Refereed]
Miyagi, Satoru, Masui, Shinji, Niwa, Hitoshi, Saito, Tetsuichiro, Shimazaki, Takuya, Okano, Hideyuki, Nishimoto, Masazumi, Muramatsu, Masami, Iwama, Atsushi, Okuda, Akihiko
FEBS LETTERS   582(18) 2811-2815   Aug 2008   [Refereed]
Okada, Yohei, Matsumoto, Arifumi, Shimazaki, Takuya, Enoki, Ryosuke, Koizumi, Amane, Ishii, Seiji, Itoyama, Yasuto, Sobue, Gen, Okano, Hideyuki
STEM CELLS   26(12) 3086-3098   2008   [Refereed]
Hayakawa-Yano, Yoshika, Nishida, Keigo, Fukami, Shinichi, Gotoh, Yukiko, Hirano, Toshio, Nakagawa, Toshiyuki, Shimazaki, Takuya, Okano, Hideyuki
STEM CELLS   25(6) 1410-1422   Jun 2007   [Refereed]
Kohno, Daisuke, Nakata, Masanori, Maekawa, Fumihiko, Fujiwara, Ken, Maejima, Yuko, Kuramochi, Motoki, Shimazaki, Takuya, Okano, Hideyuki, Onaka, Tatsushi, Yada, Toshihiko
ENDOCRINOLOGY   148(5) 2251-2263   May 2007   [Refereed]
Ozawa, Yoko, Nakao, Keiko, Shimazaki, Takuya, Shimmura, Shigeto, Kurihara, Toshihide, Ishida, Susumu, Yoshimura, Akihiko, Tsubota, Kazuo, Okano, Hideyuki
DEVELOPMENTAL BIOLOGY   303(2) 591-600   Mar 2007   [Refereed]
Iwata, Naoko, Yoshida, Hiroaki, Tobiume, Minoru, Ono, Fumiko, Shimazaki, Takuya, Sata, Tetsutaro, Nakajima, Noriko
JOURNAL OF NEUROVIROLOGY   13(1) 11-22   2007   [Refereed]
Okada, Seiji, Nakamura, Masaya, Katoh, Hiroyuki, Miyao, Tamaki, Shimazaki, Takuya, Ishii, Ken, Yamane, Junichi, Yoshimura, Akihiko, Iwamoto, Yukihide, Toyama, Yoshiaki, Okano, Hideyuki
NATURE MEDICINE   12(7) 829-834   Jul 2006   [Refereed]
Sakaguchi, M, Shingo, T, Shimazaki, T, Okano, HJ, Shiwa, M, Ishibashi, S, Oguro, H, Ninomiya, M, Kadoya, T, Horie, H, Shibuya, A, Mizusawa, H, Poirier, F, Nakauchi, H, Sawamoto, K, Okano, H
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   103(18) 7112-7117   May 2006   [Refereed]
Fukuhara, Y, Li, XK, Kitazawa, Y, Inagaki, M, Matsuoka, K, Kosuga, M, Kosaki, R, Shimazaki, T, Endo, H, Umezawa, A, Okano, H, Takahashi, T, Okuyama, T
MOLECULAR THERAPY   13(3) 548-555   Mar 2006   [Refereed]
Essential role of Shp2-binding sites on FRS2 alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells
Yamamoto, S, Yoshino, I, Shimazaki, T, Murohashi, M, Hevner, RF, Lax, I, Okano, H, Shibuya, M, Schlessinger, J, Gotoh, N
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   102(44) 15983-15988   Nov 2005   [Refereed]
Suzuki, T, Izumoto, S, Wada, K, Fujimoto, Y, Maruno, M, Yamasaki, M, Kanemura, Y, Shimazaki, T, Okano, H, Yoshimine, T
JOURNAL OF NEURO-ONCOLOGY   74(3) 233-239   Sep 2005   [Refereed]
Tomita, Y, Matsumura, K, Wakamatsu, Y, Matsuzaki, Y, Shibuya, I, Kawaguchi, H, Ieda, M, Kanakubo, S, Shimazaki, T, Ogawa, S, Osumi, N, Okano, H, Fukuda, K
JOURNAL OF CELL BIOLOGY   170(7) 1135-1146   Sep 2005   [Refereed]
Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells
Yuasa, S, Itabashi, Y, Koshimizu, U, Tanaka, T, Sugimura, K, Kinoshita, M, Hattori, F, Fukami, S, Shimazaki, T, Okano, H, Ogawa, S, Fukuda, K
NATURE BIOTECHNOLOGY   23(7) 897-897   Jul 2005   [Refereed]
Nagato, M, Heike, T, Kato, T, Yamanaka, Y, Yoshimoto, M, Shimazaki, T, Okano, H, Nakahata, T
JOURNAL OF NEUROSCIENCE RESEARCH   80(4) 456-466   May 2005   [Refereed]
Uemura, O, Okada, Y, Ando, H, Guedj, M, Higashijima, S, Shimazaki, T, Chino, N, Okano, H, Okamoto, H
DEVELOPMENTAL BIOLOGY   278(2) 587-606   Feb 2005   [Refereed]
Okada, Y, Shimazaki, T, Sobue, G, Okano, H
DEVELOPMENTAL BIOLOGY   275(1) 124-142   Nov 2004   [Refereed]
Ishibashi, S, Sakaguchi, M, Kuroiwa, T, Yamasaki, M, Kanemura, Y, Shizuko, I, Shimazaki, T, Onodera, M, Okano, H, Mizusawa, H
JOURNAL OF NEUROSCIENCE RESEARCH   78(2) 215-223   Oct 2004   [Refereed]
Nishino, J, Yamashita, K, Hashiguchi, H, Fujii, H, Shimazaki, T, Hamada, H
EMBO JOURNAL   23(9) 1998-2008   May 2004   [Refereed]
Okada, S, Nakamura, M, Mikami, Y, Shimazaki, T, Mihara, M, Ohsugi, Y, Iwamoto, Y, Yoshizaki, K, Kishimoto, T, Toyama, Y, Okano, H
JOURNAL OF NEUROSCIENCE RESEARCH   76(2) 265-276   Apr 2004   [Refereed]
ES細胞と神経幹細胞の分化
島崎琢也
CLINICAL NYUROSCIENCE   22(3) 281-283   Mar 2004
Isolation and transplantation of dopaminergic neurons generated from mouse embryonic stem cells.
'Yoshizaki T, Inaji M, Kouike H, Shimazaki T, Sawamoto K, Ando K, Date I, Kobayashi K, Suhara T, Uchiyama Y, Okano H'
Neurosci. Lett.   363 33-37   2004   [Refereed]
Implantation of dendritic cells in injured adult spinal cord results in activation of endogenous neural stem/progenitor cells leading to de novo neurogenesis and functional recovery.
'Mikami Y, Okano H, Sakaguchi M, Nakamura M, Shimazaki T, Okano HJ, Kawakami Y, Toyama Y, Toda M.'
J. Neurosci. Res.   76 453-465   2004   [Refereed]
Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina.
'Ozawa Y, Nakao K, Shimazaki T, Takeda J, Akira S, Ishihara K, Hirano T, Oguchi Y, Okano H.'
Mol. Cell. Neurosci.   26 258-270   2004   [Refereed]
Kokuzawa, J, Yoshimura, S, Kitajima, H, Shinoda, J, Kaku, Y, Iwama, T, Morishita, R, Shimazaki, T, Okano, H, Kunisada, T, Sakai, N
MOLECULAR AND CELLULAR NEUROSCIENCE   24(1) 190-197   Sep 2003   [Refereed]
ES細胞からの運動神経前駆細胞の分化誘導
島崎琢也
脳21   6(2) 137-143   Apr 2003
Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells
Chojnacki, A, Shimazaki, T, Gregg, C, Weinmaster, G, Weiss, S
JOURNAL OF NEUROSCIENCE   23(5) 1730-1741   Mar 2003   [Refereed]
ヒト神経幹細胞移植
Shimazaki Takuya, Okano Hideyuki
神経研究の進歩   46(6) 790-797   Dec 2002
Murayama, A, Matsuzaki, Y, Kawaguchi, A, Shimazaki, T, Okano, H
JOURNAL OF NEUROSCIENCE RESEARCH   69(6) 837-847   Sep 2002   [Refereed]
サイトカインによる神経幹細胞の長期維持機構
Shimazaki Takuya
神経研究の進歩   46(2) 211-219   Apr 2002
Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells
Shingo Tetsuro, Sorokan Todd S, Shimazaki Takuya, Weiss Samuel
Journal of Neuroscience   21(24) 9733-9743   Dec 2001   [Refereed]
Brain from bone: Efficient "meta-differentiation" of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent
Kohyama, J, Abe, H, Shimazaki, T, Koizumi, A, Nakashima, K, Gojo, S, Taga, T, Okano, H, Hata, J, Umezawa, A
DIFFERENTIATION   68(4-5) 235-244   Oct 2001   [Refereed]
The ciliary neurotrophic factor/leukemia inhibitory factor/gp130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells
Shimazaki Takuya, Shingo Tetsuro, Weiss Samuel
Journal of Neuroscience   21(19) 7642-7653   Oct 2001   [Refereed]
EGF-responsive neural stem cells are a transient population in the developing mouse spinal cord
Represa, A, Shimazaki, T, Simmonds, M, Weiss, S
EUROPEAN JOURNAL OF NEUROSCIENCE   14(3) 452-462   Aug 2001   [Refereed]
The bHLH gene Hes1 as a repressor of the neuronal commitment of CNS stem cells
Nakamura, Y, Sakakibara, S, Miyata, T, Ogawa, M, Shimazaki, T, Weiss, S, Kageyama, R, Okano, H
JOURNAL OF NEUROSCIENCE   20(1) 283-293   Jan 2000   [Refereed]
GFR alpha 3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion
Nishino, J, Mochida, K, Ohfuji, Y, Shimazaki, T, Meno, C, Ohishi, S, Matsuda, Y, Fujii, H, Saijoh, Y, Hamada, H
NEURON   23(4) 725-736   Aug 1999   [Refereed]
A role for the POU-III transcription factor Brn-4 in the regulation of striatal neuron precursor differentiation
Shimazaki, T, Arsenijevic, Y, Ryan, AK, Rosenfeld, MG, Weiss, S
EMBO JOURNAL   18(2) 444-456   Jan 1999   [Refereed]
HYBRID CELL EXTINCTION AND REEXPRESSION OF OCT-3 FUNCTION CORRELATES WITH DIFFERENTIATION POTENTIAL
SHIMAZAKI, T, OKAZAWA, H, FUJII, H, IKEDA, M, TAMAI, K, MCKAY, RDG, MURAMATSU, M, HAMADA, H
EMBO JOURNAL   12(12) 4489-4498   Dec 1993   [Refereed]
MURINE CHROMOSOMAL LOCATION OF 4 CLASS-III POU TRANSCRIPTION FACTORS
AVRAHAM, KB, CHO, BC, GILBERT, D, FUJII, H, OKAMOTO, K, SHIMAZAKI, T, ITO, T, SHOJI, H, WAKAMATSU, Y, KONDOH, H, TAKAHASHI, N, MURAMATSU, M, HAMADA, H, COPELAND, NG, JENKINS, NA
GENOMICS   18(1) 131-133   Oct 1993   [Refereed]

Misc

 
Shimazaki, T
HORMONE RESEARCH   60 1-9   2003
Isolation and transplantation of dopaminergic neurons and neural stem cells
Okano, H, Yoshizaki, T, Shimazaki, T, Sawamoto, K
PARKINSONISM & RELATED DISORDERS   9(1) 23-28   Oct 2002   [Refereed]

Conference Activities & Talks

 
神経幹細胞の分化に及ぼす外傷性脳損傷後の炎症性サイトカインの影響
'並木淳, 島崎琢也, 鈴木さゆり, 岡野栄之'
第27回日本神経外傷学会   Mar 2004   
骨髄由来の神経幹細胞選択的nestin遺伝子発現細胞
'並木淳, 島崎琢也, 松崎有未, 鈴木さゆり, 岡野栄之'
第3回日本再生医療学会総会   Mar 2004   
ES細胞を利用した神経再生の可能性 [Invited]
'島崎琢也, 岡野栄之'
第3回日本再生医療学会総会・シンポジウム   Mar 2004   
比較ゲノム情報学を用いたIslet-1遺伝子の神経細胞サブタイプ特異的発現機構の解明
'植村修, 岡田洋平, 安藤秀樹, Guedj Mikael, 東島眞一, 島崎琢也, 千野直一, 岡野栄之, 岡本仁'
第26回日本分子生物学会年会   Dec 2003   
Downregulation of STAT3 activation contiributes to triggering the differentiation of presumptive rod photoreceptor cells
'Ozawa Yoko, Nakao Keiko, Shimazaki Takuya, Takeda Junji, Akira Shizuo, Ishihara Katsuhiko, Hirano Toshio, Okano Hideyuki'
第26回日本分子生物学会年会   Dec 2003   

Teaching Experience

 

Research Grants & Projects

 
Transcription factors regulating temporal specification of neuronal subtypes.
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2019 - Mar 2021    Investigator(s): 島崎 琢也
Regulatory mechanisms of aging of adult neural stem/progenitor cells via p38 MAPK
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2018 - Mar 2021    Investigator(s): 島崎 琢也
Mechanisms of glial development
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2015 - Mar 2018    Investigator(s): 島崎 琢也