木村哲也 (kimura Tetsuya) - マイポータル

基本情報

所属: 東京都立健康長寿医療センター研究所認知症未来社会創造センター専門副部長 (学術博士)

J-GLOBAL ID: 201801004023689808
researchmap会員ID: B000300565

研究分野

ライフサイエンス / 神経科学一般 /

論文

Age-dependent changes in synaptic plasticity enhance tau oligomerization in the mouse hippocampus

Tetsuya Kimura, Mamiko Suzuki, Takumi Akagi

ACTA NEUROPATHOLOGICA COMMUNICATIONS 5(1) 67-67 2017年9月査読有り
Microtubule-associated tau contributes to intra-dendritic trafficking of AMPA receptors in multiple ways

Mamiko Suzuki, Tetsuya Kimura

NEUROSCIENCE LETTERS 653 276-282 2017年7月査読有り
Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice

Tomohiro Umeda, Tetsuya Kimura, Kayo Yoshida, Keizo Takao, Yuki Fujita, Shogo Matsuyama, Ayumi Sakai, Minato Yamashita, Yuki Yamashita, Kiyouhisa Ohnishi …

ACTA NEUROPATHOLOGICA COMMUNICATIONS 5(1) 59-59 2017年7月査読有り
Tau involves in hippocampal neuronal hyper-activity in hAPP transgenic mice

Misato Yoshikawa, Tetsuya Kimura, Akihiko Takashima

JOURNAL OF PHARMACOLOGICAL SCIENCES 130(3) S129-S129 2016年3月
Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups

Yoshiyuki Soeda, Misato Yoshikawa, Osborne F. X. Almeida, Akio Sumioka, Sumihiro Maeda, Hiroyuki Osada, Yasumitsu Kondoh, Akiko Saito, Tomohiro Miyasaka, Tetsuya Kimura …

NATURE COMMUNICATIONS 6 10216-10216 2015年12月査読有り
Female Hippocampus Vulnerability to Environmental Stress, a Precipitating Factor in Tau Aggregation Pathology

Ioannis Sotiropoulos, Joana Silva, Tetsuya Kimura, Ana Joao Rodrigues, Patricio Costa, Osborne F. X. Almeida, Nuno Sousa, Akihiko Takashima

JOURNAL OF ALZHEIMERS DISEASE 43(3) 763-774 2015年査読有り
Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice

Tomohiro Umeda, Satomi Maekawa, Tetsuya Kimura, Akihiko Takashima, Takami Tomiyama, Hiroshi Mori

ACTA NEUROPATHOLOGICA 127(5) 685-698 2014年5月査読有り
Contribution of Nucleus Accumbens Core (AcbC) to Behavior Control during a Learned Resting Period: Introduction of a Novel Task and Lesion Experiments

Chika Sato, Masato Hoshino, Naori Ikumi, Kentarou Oba, Akiko Koike, Osamu Shouno, Tatsuhiko Sekiguchi, Tetsuya Kobayashi, Takeo Machida, Gen Matsumoto …

PLOS ONE 9(4) 2014年4月
Microtubule-associated protein tau is essential for long-term depression in the hippocampus

Tetsuya Kimura, Daniel J. Whitcomb, Jihoon Jo, Philip Regan, Thomas Piers, Seonghoo Heo, Christopher Brown, Tsutomu Hashikawa, Miyuki Murayama, Heon Seok …

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 369(1633) 20130144-20130144 2014年1月査読有り
Neurodegenerative disorder FTDP-17-related tau intron 10 +16C → T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice.

Umeda T, Yamashita T, Kimura T, Ohnishi K, Takuma H, Ozeki T, Takashima A, Tomiyama T, Mori H

The American journal of pathology 183(1) 211-225 2013年7月査読有り
In vivo functional brain mapping in a conditional mouse model of human tauopathy (tau(p301l)) reveals reduced neural activity in memory formation structures

Pablo D. Perez, Gabrielle Hall, Tetsuya Kimura, Yan Ren, Rachel M. Bailey, Jada Lewis, Marcelo Febo, Naruhiko Sahara

MOLECULAR NEURODEGENERATION 8 9-9 2013年2月査読有り
Adaptive responses to alloxan-induced mild oxidative stress ameliorate certain tauopathy phenotypes

Yuji Yoshiike, Shunji Yamashita, Tatsuya Mizoroki, Sumihiro Maeda, Miyuki Murayama, Tetsuya Kimura, Naruhiko Sahara, Yoshiyuki Soeda, Akihiko Takashima

AGING CELL 11(1) 51-62 2012年2月査読有り
Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice

Taiki Kambe, Yumiko Motoi, Ran Inoue, Nobuhiko Kojima, Norihiro Tada, Tetsuya Kimura, Naruhiko Sahara, Shunji Yamashita, Tatsuya Mizoroki, Akihiko Takashima …

NEUROBIOLOGY OF DISEASE 42(3) 404-414 2011年6月査読有り
Chromatophore activity during natural pattern expression by the squid Sepioteuthis lessoniana: contributions of miniature oscillation.

Mamiko Suzuki, Tetsuya Kimura, Hiroto Ogawa, Kohji Hotta, Kotaro Oka

PloS one 6(4) e18244 2011年4月1日査読有り
Nucleus accumbens core mediates inhibition of redundant actions under learned no-reward situation

Chika Sato, Hiroyuki Furudate, Naori Ikumi, Kentarou Oba, Takeo Machida, Tetsuya Kimura

NEUROSCIENCE RESEARCH 71 E274-E274 2011年
Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss.

Kimura T, Fukuda T, Sahara N, Yamashita S, Murayama M, Mizoroki T, Yoshiike Y, Lee B, Sotiropoulos I, Maeda S …

The Journal of biological chemistry 285(49) 38692-38699 2010年12月査読有り
Internal representation and memory formation of odor preference based on oscillatory activities in a terrestrial slug.

Tatsuhiko Sekiguchi, Hiroyuki Furudate, Tetsuya Kimura

Learning & memory (Cold Spring Harbor, N.Y.) 17(8) 372-80 2010年8月査読有り
FMRFamide elicits chromatophore expansion and retraction depending on its type and development in the squid, Sepioteuthis lessoniana.

Mamiko Suzuki, Tetsuya Kimura, Hiroto Ogawa, Kohji Hotta, Kotaro Oka

Invertebrate neuroscience : IN 9(3-4) 185-93 2009年12月査読有り
Beneficial Effects of Estrogen in a Mouse Model of Cerebrovascular Insufficiency

Naohito Kitamura, Runa Araya, Moeko Kudoh, Haruo Kishida, Tetsuya Kimura, Miyuki Murayama, Akihiko Takashima, Yuriko Sakamaki, Tsutomu Hashikawa, Shingo Ito …

PLOS ONE 4(4) 2009年4月
Amyloid oligomer conformation in a group of natively folded proteins

Yuji Yoshiike, Ryoichi Minai, Yo Matsuo, Yun-Ru Chen, Tetsuya Kimura, Akihiko Takashima

PLoS ONE 3(9) 2008年9月18日査読有り

もっとみる

MISC

Parallel induction of synapse loss and neuronal loss in tau transgenic mice

Tetsuya Kimura, Tetsuya Fukuda, Naruhiko Sahara, Shunnji Yamashita, Tatsuya Mizoroki, Miyuki Murayama, Yuji Yoshiike, Akihiko Takashima

NEUROSCIENCE RESEARCH 61 S122-S122 2008年
GABA-linked acceleration of aging-associated memory decline in APP/PS1 transgenic mouse and its pharmacological treatment by picrotoxin

Yuji Yoshiike, Tetsuya Kimura, Shunji Yamashita, Hiroyuki Furudate, Tatsuya Mizoroki, Miyuki Murayama, Akihko Takashime

NEUROSCIENCE RESEARCH 61 S121-S121 2008年
GABA-related acceleration of aging process in Alzheimer's model mouse

Yuji Yoshiike, Tetsuya Kimura, Shunji Yamashita, Hiroyuki Furudate, Tetsuya Fukuda, Tatsuya Mizoroki, Miyuki Murayama, Akihiko Takashima

NEUROSCIENCE RESEARCH 58 S176-S176 2007年
Morphological analysis of human tau transgenic mice showing age-dependent learning disorders

Tetsuya Fukuda, Tetsuya Kimura, Tetsuaki Arai, Shunji Yamashita, Tatsuya Mizoroki, Yung-Mi Park, Miyuki Murayama, Naruhiko Sahara, Haruhiko Akiyama, Akihiko Takashima

NEUROSCIENCE RESEARCH 58 S175-S175 2007年
Change in behavioral modes causes differential activities of hippocampal neurons in rats during maze learning

Naoko Izumi, Hiroyuki Furudate, Tatsuhiko Sekiguchi, Tetsuya Kimura, Takeo Machida

ZOOLOGICAL SCIENCE 23(12) 1188-1188 2006年12月
Effect of lesions of the nucleus accumbens on behavioral mode change during learning in rats

Naori Ikumi, Hiroyuki Furudate, Tatsuhiko Sekiguchi, Tetsuya Kimura, Takeo Machida

ZOOLOGICAL SCIENCE 23(12) 1188-1188 2006年12月
Neural control mechanisms in chromatophore organs of squid, Sepioteuthis lessoniana

Mamiko Suzuki, Tetsuya Kimura, Hiroto Ogawa, Hitoshi Aonuma, Yoshiichiro Kitamura, Kohji Hotta, Kotaro Oka

ZOOLOGICAL SCIENCE 23(12) 1187-1187 2006年12月査読有り
Neural networks controlling squid chromatophore organs in local skin area

Mamiko Suzuki, Tetsuya Kimura, Hitoshi Aonuma, Yoshiichiro Kitamura, Hiroto Ogawa, Kohji Hotta, Kotaro Oka

ZOOLOGICAL SCIENCE 22(12) 1489-1489 2005年12月査読有り
PHYSIOLOGICAL ANASYSIS OF SPONTANEOUS NEURAL ACTIVITY OF TENTACULAR GANGLION IN THE TERRESTRIAL SLUG, Limax marginatus(Physiology)Proceedings of the Seventy-First Annual Meeting of the Zoological Society of Japan :

Ito I., Kimura T., Ito E.

Zoological science 17 100-100 2000年

共同研究・競争的資金等の研究課題

神経核の脱落がタウ病理形成に与える影響の解明

日本学術振興会科学研究費助成事業挑戦的萌芽研究 2015年4月 - 2018年3月

吉田裕孝, 木村哲也
神経原線維変化形成機構

日本学術振興会科学研究費助成事業特定領域研究 2006年 - 2007年

高島明彦, 佐原成彦, 木村哲也, 福田哲也, 吉池裕二, 前田純宏
神経原線維変化形成機構

日本学術振興会科学研究費助成事業特定領域研究 2005年 - 2005年

高島明彦, 佐原成彦, 木村哲也, 福田哲也, 吉池裕二

木村哲也

基本情報

研究分野

論文

MISC

共同研究・競争的資金等の研究課題

メニュー

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