Tomohiro Nishizawa

Membrane structure‐responsive lipid scramblase activity of the <scp>TMEM63</scp>/<scp>OSCA</scp> family

Yugo Miyata, Megumi Nishimura, Aya Nagata, Xu Jing, Cheryl S. Sultan, Risa Kuribayashi, Katsuya Takahashi, Yongchan Lee, Tomohiro Nishizawa, Katsumori Segawa

FEBS Letters, Dec 23, 2024

Membrane structure-responsive lipid scrambling by TMEM63B to control plasma membrane lipid distribution.

Yugo Miyata, Katsuya Takahashi, Yongchan Lee, Cheryl S Sultan, Risa Kuribayashi, Masatomo Takahashi, Kosuke Hata, Takeshi Bamba, Yoshihiro Izumi, Kehong Liu …

Nature structural & molecular biology, Oct 18, 2024

The unique allosteric property of crocodilian haemoglobin elucidated by cryo-EM.

Katsuya Takahashi, Yongchan Lee, Angela Fago, Naim M Bautista, Jay F Storz, Akihiro Kawamoto, Genji Kurisu, Tomohiro Nishizawa, Jeremy R H Tame

Nature communications, 15(1) 6505-6505, Aug 2, 2024

Cryo-EM structures elucidate the multiligand receptor nature of megalin.

Sawako Goto, Akihisa Tsutsumi, Yongchan Lee, Michihiro Hosojima, Hideyuki Kabasawa, Koichi Komochi, Satoru Nagatoishi, Kazuya Takemoto, Kouhei Tsumoto, Tomohiro Nishizawa …

Proceedings of the National Academy of Sciences of the United States of America, 121(22) e2318859121, May 28, 2024

Structure of the human Bre1 complex bound to the nucleosome.

Shuhei Onishi, Kotone Uchiyama, Ko Sato, Chikako Okada, Shunsuke Kobayashi, Keisuke Hamada, Tomohiro Nishizawa, Osamu Nureki, Kazuhiro Ogata, Toru Sengoku

Nature communications, 15(1) 2580-2580, Mar 22, 2024

Bicarbonate signalling via G protein-coupled receptor regulates ischaemia-reperfusion injury.

Airi Jo-Watanabe, Toshiki Inaba, Takahiro Osada, Ryota Hashimoto, Tomohiro Nishizawa, Toshiaki Okuno, Sayoko Ihara, Kazushige Touhara, Nobutaka Hattori, Masatsugu Oh-Hora …

Nature communications, 15(1) 1530-1530, Feb 27, 2024

Mechanically-sensitive fluorochromism by molecular domino transformation in a Schiff base crystal

Toshiyuki Sasaki, Takanori Nakane, Akihiro Kawamoto, Yakai Zhao, Yushi Fujimoto, Tomohiro Nishizawa, Nabadeep Kalita, Seiji Tsuzuki, Fuyuki Ito, Upadrasta Ramamurty …

Journal of Materials Chemistry C, Jan, 2024 Peer-reviewed

Twisting and Protonation of Retinal Chromophore Regulate Channel Gating of Channelrhodopsin C1C2

Keisei Shibata, Kazumasa Oda, Tomohiro Nishizawa, Yuji Hazama, Ryohei Ono, Shunki Takaramoto, Reza Bagherzadeh, Hiromu Yawo, Osamu Nureki, Keiichi Inoue …

Journal of the American Chemical Society, 145(19) 10779-10789, May 2, 2023

Microcrystal electron diffraction (MicroED) structure determination of a mechanochemically synthesized co-crystal not affordable from solution crystallization

Toshiyuki Sasaki, Takanori Nakane, Akihiro Kawamoto, Tomohiro Nishizawa, Genji Kurisu

CrystEngComm, 2023 Peer-reviewed

Cryo-EM structures of thylakoid-located voltage-dependent chloride channel VCCN1

Tatsuya Hagino, Takafumi Kato, Go Kasuya, Kan Kobayashi, Tsukasa Kusakizako, Shin Hamamoto, Tomoaki Sobajima, Yuichiro Fujiwara, Keitaro Yamashita, Hisashi Kawasaki …

Nature Communications, 13(1), Dec, 2022

RNA-triggered protein cleavage and cell growth arrest by the type III-E CRISPR nuclease-protease.

Kazuki Kato, Sae Okazaki, Cian Schmitt-Ulms, Kaiyi Jiang, Wenyuan Zhou, Junichiro Ishikawa, Yukari Isayama, Shungo Adachi, Tomohiro Nishizawa, Kira S Makarova …

Science (New York, N.Y.), 378(6622) 882-889, Nov 25, 2022

Structure of the IscB–ωRNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9

Kazuki Kato, Sae Okazaki, Soumya Kannan, Han Altae-Tran, F. Esra Demircioglu, Yukari Isayama, Junichiro Ishikawa, Masahiro Fukuda, Rhiannon K. Macrae, Tomohiro Nishizawa …

Nature Communications, 13(1), Nov 7, 2022

PTH1受容体における内在性リガンドの認識機構と構造ダイナミクス

小林和弘, 川上耕季, 草木迫司, 郷野弘剛, 富田敦弘, 小林幹, 志甫谷渉, 山下恵太郎, 西澤知宏, 加藤英明 …

日本生化学会大会プログラム・講演要旨集, 95回 2T12a-07, Nov, 2022

Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility

Haon Futamata, Masahiro Fukuda, Rie Umeda, Keitaro Yamashita, Atsuhiro Tomita, Satoe Takahashi, Takafumi Shikakura, Shigehiko Hayashi, Tsukasa Kusakizako, Tomohiro Nishizawa …

Nature Communications, 13(6208), Oct 20, 2022 Peer-reviewed

Structure and function of H+/K+ pump mutants reveal Na+/K+ pump mechanisms

Victoria C. Young, Hanayo Nakanishi, Dylan J. Meyer, Tomohiro Nishizawa, Atsunori Oshima, Pablo Artigas, Kazuhiro Abe

Nature Communications, 13(1), Sep 9, 2022

Structure and engineering of the minimal type VI CRISPR-Cas13bt3.

Ryoya Nakagawa, Soumya Kannan, Han Altae-Tran, Satoru N Takeda, Atsuhiro Tomita, Hisato Hirano, Tsukasa Kusakizako, Tomohiro Nishizawa, Keitaro Yamashita, Feng Zhang …

Molecular cell, 82(17) 3178-3192, Sep 1, 2022

Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2

Takafumi Kato, Tsukasa Kusakizako, Chunhuan Jin, Xinyu Zhou, Ryuichi Ohgaki, LiLi Quan, Minhui Xu, Suguru Okuda, Kan Kobayashi, Keitaro Yamashita …

Nature Communications, 13(1), Aug 11, 2022

Endogenous ligand recognition and structural transition of a human PTH receptor.

Kazuhiro Kobayashi, Kouki Kawakami, Tsukasa Kusakizako, Hirotake Miyauchi, Atsuhiro Tomita, Kan Kobayashi, Wataru Shihoya, Keitaro Yamashita, Tomohiro Nishizawa, Hideaki E Kato …

Molecular cell, 82(18) 3468-3483, Aug 4, 2022

クライオ電子顕微鏡によるヒト由来メラトニン受容体シグナル伝達複合体の立体構造解析(Cryo-EM structure of the human MT1-Gi signaling complex)

Okamoto Hiroyuki, Miyauchi Hirotake, Inoue Asuka, Raimondi Francesco, Tsujimoto Hirokazu, Kusakizako Tsukasa, Shihoya Wataru, Yamashita Keitaro, Suno Ryoji, Nomura Norimichi …

生物物理, 62(Suppl.1-2) S347-S347, Aug, 2022

Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex.

Sonomi Yamaguchi, Masahiro Naganuma, Tomohiro Nishizawa, Tsukasa Kusakizako, Yukihide Tomari, Hiroshi Nishimasu, Osamu Nureki

Nature, 607(7918) 393-398, Jul, 2022

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