西澤知宏 (Tomohiro Nishizawa) - 論文

Structure and engineering of the type III-E CRISPR-Cas7-11 effector complex

Kazuki Kato, Wenyuan Zhou, Sae Okazaki, Yukari Isayama, Tomohiro Nishizawa, Jonathan S. Gootenberg, Omar O. Abudayyeh, Hiroshi Nishimasu

Cell 185(13) 2324-2337.e16 2022年6月

Structure of the type V-C CRISPR-Cas effector enzyme.

Nina Kurihara, Ryoya Nakagawa, Hisato Hirano, Sae Okazaki, Atsuhiro Tomita, Kan Kobayashi, Tsukasa Kusakizako, Tomohiro Nishizawa, Keitaro Yamashita, David A Scott …

Molecular cell 82(10) 1865-1877 2022年5月19日

Structural insights into the HBV receptor and bile acid transporter NTCP.

Jae-Hyun Park, Masashi Iwamoto, Ji-Hye Yun, Tomomi Uchikubo-Kamo, Donghwan Son, Zeyu Jin, Hisashi Yoshida, Mio Ohki, Naito Ishimoto, Kenji Mizutani …

Nature 606(7916) 1027-1031 2022年5月17日

PTH1Rの構造多形から明らかになったリガンド認識における分子相互基盤と持続的受容体活性化メカニズム

小林和弘, 川上耕季, 草木迫司, 郷野弘剛, 富田篤弘, 小林幹, 志甫谷渉, 山下恵太郎, 西澤知宏, 加藤英明 …

日本薬理学会年会要旨集 95 2-YIA-66 2022年

Cryo-EM of the ATP11C flippase reconstituted in Nanodiscs shows a distended phospholipid bilayer inner membrane around transmembrane helix 2.

Hanayo Nakanishi, Kenichi Hayashida, Tomohiro Nishizawa, Atsunori Oshima, Kazuhiro Abe

The Journal of biological chemistry 298(1) 101498-101498 2021年12月17日

Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2.

Atsuhiro Tomita, Takashi Daiho, Tsukasa Kusakizako, Keitaro Yamashita, Satoshi Ogasawara, Takeshi Murata, Tomohiro Nishizawa, Osamu Nureki

Molecular cell 81(23) 4799-4809 2021年12月2日

Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2.

Ko Sato, Amarjeet Kumar, Keisuke Hamada, Chikako Okada, Asako Oguni, Ayumi Machiyama, Shun Sakuraba, Tomohiro Nishizawa, Osamu Nureki, Hidetoshi Kono …

Nature communications 12(1) 6605-6605 2021年11月15日

Cryo-EM structures reveal the electromotility mechanism of prestin, the cochlear amplifier

Haon Futamata, Masahiro Fukuda, Rie Umeda, Keitaro Yamashita, Satoe Takahashi, Takafumi Shikakura, Shigehiko Hayashi, Kazuaki Homma, Tomohiro Nishizawa, Osamu Nureki

Research square 2021年10月1日

Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations.

Kazuhiro Abe, Kenta Yamamoto, Katsumasa Irie, Tomohiro Nishizawa, Atsunori Oshima

Nature communications 12(1) 5709-5709 2021年9月29日

Structural basis of gating modulation of Kv4 channel complexes.

Yoshiaki Kise, Go Kasuya, Hiroyuki H Okamoto, Daichi Yamanouchi, Kan Kobayashi, Tsukasa Kusakizako, Tomohiro Nishizawa, Koichi Nakajo, Osamu Nureki

Nature 599(7883) 158-164 2021年9月22日

Cryo-EM structure of the β3-adrenergic receptor reveals the molecular basis of subtype selectivity.

Chisae Nagiri, Kazuhiro Kobayashi, Atsuhiro Tomita, Masahiko Kato, Kan Kobayashi, Keitaro Yamashita, Tomohiro Nishizawa, Asuka Inoue, Wataru Shihoya, Osamu Nureki

Molecular cell 81(15) 3205-3215 2021年8月5日

Cryo-EM structure of the human MT1-Gi signaling complex.

Hiroyuki H Okamoto, Hirotake Miyauchi, Asuka Inoue, Francesco Raimondi, Hirokazu Tsujimoto, Tsukasa Kusakizako, Wataru Shihoya, Keitaro Yamashita, Ryoji Suno, Norimichi Nomura …

Nature structural & molecular biology 28(8) 694-701 2021年8月

Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin.

Kazumasa Oda, Takashi Nomura, Takanori Nakane, Keitaro Yamashita, Keiichi Inoue, Shota Ito, Johannes Vierock, Kunio Hirata, Andrés D Maturana, Kota Katayama …

eLife 10 2021年3月23日

Structure of the miniature type V-F CRISPR-Cas effector enzyme.

Satoru N Takeda, Ryoya Nakagawa, Sae Okazaki, Hisato Hirano, Kan Kobayashi, Tsukasa Kusakizako, Tomohiro Nishizawa, Keitaro Yamashita, Hiroshi Nishimasu, Osamu Nureki

Molecular cell 81(3) 558-570 2021年2月4日

Mitochondrial sorting and assembly machinery operates by β-barrel switching.

Hironori Takeda, Akihisa Tsutsumi, Tomohiro Nishizawa, Caroline Lindau, Jon V Busto, Lena-Sophie Wenz, Lars Ellenrieder, Kenichiro Imai, Sebastian P Straub, Waltraut Mossmann …

Nature 590(7844) 163-169 2021年2月

Cryo-EM structures of Toll-like receptors in complex with UNC93B1.

Hanako Ishida, Jinta Asami, Zhikuan Zhang, Tomohiro Nishizawa, Hideki Shigematsu, Umeharu Ohto, Toshiyuki Shimizu

Nature structural & molecular biology 28(2) 173-180 2021年2月

Consensus mutagenesis approach improves the thermal stability of system xc- transporter, xCT, and enables cryo-EM analyses.

Kazumasa Oda, Yongchan Lee, Pattama Wiriyasermkul, Yoko Tanaka, Mizuki Takemoto, Keitaro Yamashita, Shushi Nagamori, Tomohiro Nishizawa, Osamu Nureki

Protein science : a publication of the Protein Society 29(12) 2398-2407 2020年12月

Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM.

Hanayo Nakanishi, Tomohiro Nishizawa, Katsumori Segawa, Osamu Nureki, Yoshinori Fujiyoshi, Shigekazu Nagata, Kazuhiro Abe

Cell reports 32(13) 108208-108208 2020年9月29日

Gタンパク質共役型受容体の構造機能相関:創薬の新戦略に向けてクライオ電子顕微鏡解析で見えてきたGPCRの分子機構

濡木理, 岡本紘幸, 小林和弘, 名切千彩恵, 志甫谷渉, 西澤知宏

日本生化学会大会プログラム・講演要旨集 93回 [2S03e-02] 2020年9月

Cryo-EM structures of SERCA2b reveal the mechanism of regulation by the luminal extension tail.

Yuxia Zhang, Michio Inoue, Akihisa Tsutsumi, Satoshi Watanabe, Tomohiro Nishizawa, Kazuhiro Nagata, Masahide Kikkawa, Kenji Inaba

Science advances 6(33) eabb0147 2020年8月

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