Tadahiko Kubo

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Name
Tadahiko Kubo
E-mail
kubothiroshima-u.ac.jp
Affiliation
Hiroshima University
Research funding number
70397959

Research Interests

 
 

Research Areas

 
 

Awards & Honors

 
Jun 2009
American/Japanese orthopaedic association traveling fellow
 
Mar 2010
IFN, AAOS best poster
 
Feb 2004
Wnt, Investigator Recognition Awards in the 50st Annual Meeting of Orthopaedic Research Society
 
Feb 2003
STI, New Investigator Recognition Awards in the 49st Annual Meeting of Orthopaedic Research Society
 
Oct 2000
British Orthopaedic Association/Japanese Orthopaedic Association Traveling Fellow
 

Published Papers

 
Kubo, Tadahiko; Shimose, Shoji; Matsuo, Toshihiro; Fujimori, Jun; Sakaguchi, Takemasa; Yamaki, Minoru; Shinozaki, Katsunori; Woo, Savio L. C.; Ochi, Mitsuo
JOURNAL OF ORTHOPAEDIC RESEARCH   29(5) 795-800   May 2011   [Refereed]
A significant limitation to oncolytic virotherapy in vivo is the lack of a clinically relevant means of delivering the virus. We evaluated the oncolytic activity of vesicular stomatitis virus (VSV) in human osteosarcoma cells and explored isolated...
Fujimori, Jun; Matsuo, Toshihiro; Shimose, Shoji; Kubo, Tadahiko; Ishikawa, Masakazu; Yasunaga, Yuji; Ochi, Mitsuo
JOURNAL OF ORTHOPAEDIC RESEARCH   29(11) 1707-1711   Nov 2011   [Refereed]
Telomere studies in carcinomas have been extensively reported for prognostic utility and effective methods for targeting telomerase therapy has been described, but efficacy of telomerase inhibitor remained unknown in sarcoma cells. In this study, ...
Effect of thermosensitive liposomal doxorubicin with hyperthermia on primary tumor and lung metastases in hamster osteosarcoma
INTERNATIONAL JOURNAL OF ONCOLOGY   19 585-589   Sep 2001   [Refereed]
Effect of thermosensitive liposomal doxorubicin with hyperthermia on primary tumor and lung metastases in hamster osteosarcoma
INTERNATIONAL JOURNAL OF ONCOLOGY   19 585-589   Apr 2001   [Refereed]
Targeted gene delivery to human osteosarcoma cells with magnetic cationic liposomes under a magnetic field
INTERNATIONAL JOURNAL OF ONCOLOGY   22 1065-1071   Apr 2003   [Refereed]
Connective tissue growth factor is an indicator of bone involvement in multiple myeloma, but matrix metalloproteinase-9 is not.
Br J Haematol   139 41-50   Sep 2007   [Refereed]
Major-nerve schwannomas versus intramuscular schwannomas.
Acta Radiol   48(6):672-7(48(6):672-7) 48(6):672-7   Sep 2007   [Refereed]
Telomere length and telomerase activity in extra-abdominal desmoid tumors.
ANTICANCER RESEARCE   411-5.   Jan 2007   [Refereed]
Telomerase activity in giant cell tumors of bone.
Ann Surg Oncol   14 2896-902.   Mar 2007   [Refereed]
Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma.
Int J Cancer   121 943-54   Jan 2007   [Refereed]
Nerve tolerance to high-dose-rate brachytherapy in patients with soft tissue sarcoma: a retrospective study.
BMC Cancer   5(1) 79-8   Sep 2005   [Refereed]
Postradiation malignant fibrous histiocytomaand osteosarcoma developing in bilateral tibia.
ANTICANCER RESEARCE   2951-5   Oct 2005   [Refereed]
Clinical outcomes of 54 pelvic osteosarcoma registered by Japanese Musculo-skeletal Oncology Group.
Oncology   68(4-6) 375-81   Oct 2005   [Refereed]
Reconstructed patellar tendon length after proximal tibia prosthetic replacement.
Clin Orthop Relat Res   439 176-80   Oct 2005   [Refereed]
Cell proliferation of cultured human cancer cells areaffected by the elevated tumor pressures that exist in vivo
Ann Biomed Eng   33(9) 1270-80   Sep 2005   [Refereed]
Efficiency of magnetic liposomal transforming growth factor-beta 1 in the repair of articular cartilagedefects in a rabbit model.
J Biomed Mater Res A.   73(3) 255-63   Sep 2005   [Refereed]
Acetabular osteosarcoma treated by irradiation-vascularized hybrid bone graft.
ANTICANCER RESEARCE   1889-92   Nov 2004   [Refereed]
Histological findings in a human autogenous pasteurized bone graft.
ANTICANCER RESEARCE   1893-6   Sep 2004   [Refereed]
Hyperthermia using magnetite cationic liposomes for hamster osteosarcoma.
Biomagn Res Technol.   25;2(1):3 1-6   Oct 2004   [Refereed]
Evaluation of systemic chemotherapy with magnetic liposomal doxorubicin and a dipole external electromagnet.
Int J Cancer   109(4) 627-35   Oct 2004   [Refereed]
Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma.
Int J Cancer.   109(1) 106-11   Sep 2004   [Refereed]
Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway.
Cancer res.   64(8) 2734-9   Oct 2004   [Refereed]
Injectable magnetic liposomes as a novel carrier of recombinant human BMP-2 for bone formation in a rat bone defect model
Journal of Biomedical Materials Research   (66A) 1065-71   Apr 2003
Targeted gene delivery to human osteosarcoma cells with magnetic cationic liposomes under magnetic field
Int J Oncology May   (22) 1065-71   Apr 2003
Evaluation of systemic chemotherapy with magnetic liposomal doxrubicin and dipole external electromagnet
Int J Cancer   109(4) 627-35   Apr 2004
Efficiency of magnetic liposomal transforming growth factor-beta 1 in the repair of articular cartilage defects in a rabbit model
Journal of Biomedical Materials Research   (73A) 255-263   Mar 2005
Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cells
J Orthop Res   (24) 1138-44   Jun 2006
Major nerve schwannomas vs intramuscular schwannomas
Acta Radiologica   48(6) 672-677   Jan 2007   [Refereed]
Reconstructed patellar tendon length after proximal tibia prosthetic replacement.
Clinical Orthopedic Related Research   439 176-180   Oct 2005   [Refereed]
Conservative surgery for well-differentiated liposarcomas of the extremities adjacent to major neurovascular structures
Surg Oncol   15(3) 167-171   Dec 2006   [Refereed]
Efficacy of a nitrogen-containing bisphosphonate, minodronate, in conjunction with a p38 mitogen activated protein kinase inhibitor or doxorubicin against malignant bone tumor cells.
Cancer Chemotherapy and Pharmacology   62(1) 111-6   Oct 2008   [Refereed]
Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma.
Cancer   112(10) 2119-29   Nov 2008   [Refereed]
Rigid bridging of massive femur defect using double vascularized fibula graft with hydroxyapatite.
Archives of Orthopaedic and Traumatic Surgery.      Feb 2008   [Refereed]
Scalp metastasis from malignant fibrous histiocytoma of bone.
J Am Acad Dermatol   59(5) 88-91   Apr 2008   [Refereed]
Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.
J Am Chem Soc      Apr 2009   [Refereed]
Telomere-maintenance mechanisms in soft-tissue malignant fibrous histiocytomas.
J Bone Joint Surg Am      Apr 2009   [Refereed]
Telomeres and telomerase in sarcomas.
Anticancer Res.      Oct 2009   [Refereed]
Liposarcoma arising in the foot: a case report.
Case Report Med.      Aug 2009
Extraskeletal osteosarcoma with partial spontaneous regression.
Anticancer Res.      Dec 2009   [Refereed]
Minodronate for the treatment of osteoporosis
Drugs Today (Barc)   46(1) 33-37   Jan 2010   [Refereed]
Oncolytic vesicular stomatitis virus administered by isolated limb perfusion suppresses osteosarcoma growth.
Journal of Orthopaedic Research   29(5) 795-800   May 2011   [Refereed]
Oncolytic vesicular stomatitis virus administered by isolated limb perfusion suppresses osteosarcoma growth.
29((5)) 795-800   May 2011   [Refereed]
Targeted systemic chemotherapy using magnetic liposomes with incorporated adriamycin for osteosarcoma in hamsters
Kubo, T; Sugita, T; Shimose, S; Nitta, Y; Ikuta, Y; Murakami, T
INTERNATIONAL JOURNAL OF ONCOLOGY   18(1) 121-125   Jan 2001   [Refereed]
To control the growth of primary tumors effectively with systemic chemotherapy, we recently developed intravenously administered small-sized magnetic liposomes as an anticancer drug carrier. We previously reported that intravenously administered m...
Effect of thermosensitive liposomal doxorubicin with hyperthermia on primary tumor and lung metastases in hamster osteosarcoma
Shimose, S; Sugita, T; Nitta, Y; Kubo, T; Ikuta, Y; Murakami, T
INTERNATIONAL JOURNAL OF ONCOLOGY   19(3) 585-589   Sep 2001   [Refereed]
We evaluated the effect of intravenous thermosensitive liposomal doxorubicin (TL-DOX) together with local hyperthermia on primary tumors in highly metastatic hamster osteosarcoma. This combination resulted in higher DOX concentrations in plasma, p...
Targeted gene delivery to human osteosarcoma cells with magnetic cationic liposomes under a magnetic field
Hirao, K; Sugita, T; Kubo, T; Igarashi, K; Tanimoto, K; Murakami, T; Yasunaga, Y; Ochi, M
INTERNATIONAL JOURNAL OF ONCOLOGY   22(5) 1065-1071   May 2003   [Refereed]
Gene delivery using cationic liposomes results in relatively low transfection, especially under in vivo conditions. This system, however, can overcome some of the problems associated with viral delivery systems. The present study was carried out i...
Matsuo, Toshihiro; Hiyama, Eiso; Sugita, Takashi; Shimose, Shoji; Kubo, Tadahiko; Mochizuki, Yu; Adachi, Nobuo; Kojima, Kensaku; Sharman, Patrick; Ochi, Mitsuo
ANNALS OF SURGICAL ONCOLOGY   14(10) 2896-2902   Oct 2007   [Refereed]
Background: A giant cell tumor of bone (GCT) is a histologically benign neoplasma that has an unpredictable pattern of biological aggressiveness. In the present study, we investigated whether there was a correlation between telomere length or the ...
Kubo, Tadahiko; Shimose, Shoji; Matsuo, Toshihiro; Sakai, Akira; Ochi, Mitsuo
CANCER CHEMOTHERAPY AND PHARMACOLOGY   62(1) 111-116   Jun 2008   [Refereed]
Purpose We recently reported the sarcoma-selective antitumor effects of a newly developed nitrogen-containing bisphosphonate, minodronate (MIN), on malignant bone tumors. The aim of this study was to develop efficient combination MIN therapy in ma...
Kubo, Todahiko; Shimose, Shoji; Matsu, Toshihiro; Fujimori, Jun; Ochi, Mitsuo
DRUGS OF TODAY   46(1) 33-37   Jan 2010   [Refereed]
Minodronate, a new nitrogen-containing bisphosphonate, was developed in Japan. It was the first drug to demonstrate significant prevention of vertebral fractures in Japanese patients with osteoporosis in a phase Ill double-blind comparative study....
Alternative Lengthening of Telomeres as a Prognostic Factor in Malignant Fibrous Histiocytomas of Bone
Matsuo, Toshihiro; Shimose, Shoji; Kubo, Tadahiko; Fujimori, Jun; Yasunaga, Yuji; Ochi, Mitsuo
ANTICANCER RESEARCH   30(12) 4959-4962   Dec 2010   [Refereed]
Background: Malignant fibrous histiocytoma (MFH) of bone is a rare primary malignant neoplasm. Recent studies indicate a positive correlation between the telomere maintenance mechanism and tumour aggressiveness in sarcomas. This study was undertak...
Kubo, Tadahiko; Shimose, Shoji; Matsuo, Toshihiro; Fujimori, Jun; Arihiro, Koji; Ochi, Mitsuo
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME   93A(6) 519-526   Mar 2011   [Refereed]
Background: A large-scale randomized trial of adjuvant interferon-alpha therapy for patients with osteosarcoma has been initiated as a joint protocol by the European and American Osteosarcoma Study Group. Because the expression of functional inter...
Matsuo, Toshihiro; Shimose, Shoji; Kubo, Tadahiko; Fujimori, Jun; Yasunaga, Yuji; Sugita, Takashi; Ochi, Mitsuo
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH   31    Jan 2012   [Refereed]
Background: One of the major components of telomerase is the human telomerase reverse transcriptase (hTERT) as the catalytic protein. hTERT mRNA expression are reported to be associated with prognosis and tumor progression in several sarcomas. How...
Ujigo, Satoshi; Shimose, Shoji; Kubo, Tadahiko; Fujimori, Jun; Ochi, Mitsuo
JOURNAL OF ORTHOPAEDIC SCIENCE   19(1) 150-155   Jan 2014   [Refereed]
Benign schwannoma is the most common tumor of peripheral nerves. However, the clinical course of excision and risk factors associated with postoperative neurological deficits are not well known. We evaluated the incidence of preoperative symptoms,...
Shimbo, Keisuke; Miyaki, Shigeru; Ishitobi, Hiroyuki; Kato, Yoshio; Kubo, Tadahiko; Shimose, Shoji; Ochi, Mitsuo
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   445(2) 381-387   Mar 2014   [Refereed]
MicroRNAs (miRNAs) have emerged as potential anticancer agents, but their clinical application is limited by the lack of an effective delivery system to tumors. Exosomes are small vesicles that play important roles in intercellular communication. ...
Shimose, Shoji; Kubo, Tadahiko; Fujimori, Jun; Furuta, Taisuke; Ochi, Mitsuo
JOURNAL OF ORTHOPAEDIC SCIENCE   19(6) 997-1003   Nov 2014   [Refereed]
Background A high serum alkaline phosphatase (ALP) level is valuable for the diagnosis of osteosarcoma in adults, but its use in teenagers is problematic because ALP levels are affected by age, gender, and pubertal stage. Because serum acid phosph...
Kubo, Tadahiko; Shimose, Shoji; Fujimori, Jun; Furuta, Taisuke; Arihiro, Koji; Ochi, Mitsuo
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH   473(1) 305-310   Jan 2015   [Refereed]
The survival of patients who present with nonmetastatic extremity osteosarcoma has dramatically improved, but there are some patients who do not respond to chemotherapy. The ability to identify patients with a poorer prognosis might allow us to ta...
Saad, Ali; Zhu, Wei; Rousseau, Guillaume; Mialane, Pierre; Marrot, Jerome; Haouas, Mohamed; Taulelle, Francis; Dessapt, Remi; Serier-Brault, Helene; Riviere, Eric et al.
CHEMISTRY-A EUROPEAN JOURNAL   21(29) 10537-10547   Jul 2015   [Refereed]
Six polyoxometalates containing Mn-II, Mn-III, or Fe-III as the heteroelement were synthesized in water by treating Mo-VI precursors with biologically active bisphosphonates (alendronate (Ale), zoledronate (Zol), an n-alkyl bisphosphonate (BPC9), ...
Kubo, Tadahiko; Shimose, Shoji; Fujimori, Jun; Furuta, Taisuke; Ochi, Mitsuo
SPRINGERPLUS   4    Jul 2015   [Refereed]
SS18-SSX (formerly called SYT-SSX) fusion gene has been established clinically as a molecular diagnostic test for synovial sarcoma, but the prognostic value of the fusion gene variant for survival is controversial. The objective of this systematic...
Extra-osseous extension caused by epidural hematoma in Gaucher disease mimicking malignant bone tumor
Kubo T, Shimose S, Fujimori J, Shimizu R, Ochi M.
Journal of Inherited Metabolic Disease Reports   14(1) 67-70   Jan 2014
Kubo, Tadahiko; Shimose, Shoji; Fujimori, Jun; Furuta, Taisuke; Ochi, Mitsuo
SURGICAL ONCOLOGY-OXFORD   24(3) 194-199   Sep 2015   [Refereed]
Purpose: The histological assessment of tumor necrosis of the excised lesion after neoadjuvant chemotherapy is the most important prognostic factor for patients with osteosarcoma, but more early prognostic factors are needed for the adjustment of ...
Kubo, Tadahiko; Shimose, Shoji; Fujimori, Jun; Furuta, Taisuke; Ochi, Mitsuo
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY   96(1) 46-53   Oct 2015   [Refereed]
Purpose: The objective of this systematic review is to provide an unprecedented summary of the prognostic impact of PAX3/7-FOXO1 fusion status in alveolar rhabdomyosarcoma. Methods: Studies evaluating PAX3/7-FOXO1 fusion gene or its variants as a ...
More than 20-year Follow-Up After Vascularised Fibula Head Graft for Oncological Shoulder Joint Reconstruction
Kubo, Tadahiko; Furuta, Taisuke; Ochi, Mitsuo
ANTICANCER RESEARCH   36(1) 301-305   Jan 2016   [Refereed]
Background: In our Department, the vascularized fibula head has been the preferred option for proximal humerus reconstruction for approximately 30 years. The purpose of the present study was to analyze the long-term functional outcome for oncologi...
Kubo, Tadahiko; Furuta, Taisuke; Johan, Muhammad P.; Ochi, Mitsuo
EUROPEAN JOURNAL OF CANCER   58(1) 104-111   May 2016   [Refereed]
Purpose: The usefulness of F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG PET) for the survival prognosis in soft tissue sarcoma (STS) and bone sarcoma (BS) is controversial. The objective of this systematic review was to provide a...
Kubo, Tadahiko; Furuta, Taisuke; Johan, Muhammad P.; Adachi, Nobuo; Ochi, Mitsuo
SKELETAL RADIOLOGY   45(9) 1235-1242   Sep 2016   [Refereed]
The objective of this systematic review is to provide an up-to-date and unprecedented summary of percent slope analysis of dynamic magnetic resonance imaging (MRI) for the preoperative evaluation of the chemotherapy response of osteosarcoma or Ewi...
Tanaka, Kazuhiro; Joyama, Susumu; Chuman, Hirokazu; Hiraga, Hiroaki; Morioka, Hideo; Yoshikawa, Hideki; Hosaka, Masami; Takahashi, Mitsuru; Kubo, Tadahiko; Hatano, Hiroshi; Kaya, Mitsunori; Toguchida, Junya; Nishida, Yoshihiro; Nagano, Akihito; Tsumura, Hiroshi; Iwamoto, Yukihide
WORLD JOURNAL OF SURGICAL ONCOLOGY   14(1) 306   Dec 2016   [Refereed]
Background: Bone and soft tissue sarcomas (BSTS) are rare malignant tumors. Recently, the combination of gemcitabine and docetaxel (GD) was shown to have activity as second-line setting in BSTS. However, the efficacy as first-line and adjuvant set...
Kubo, Tadahiko; Furuta, Taisuke; Johan, Muhammad P.; Yoshizuka, Masaaki; Ochi, Mitsuo; Adachi, Nobuo
MEDICINE   96(18)    May 2017   [Refereed]
Histologically conventional osteosarcoma, once metastasized to the lung, generally causes a rapid and fatal outcome. Osteosarcoma metastasis to the gastrointestinal tract is extremely rare. We report herein a case of osteoblastic osteosarcoma with...
Boulmier, Amandine; Feng, Xinxin; Oms, Olivier; Mialane, Pierre; Riviere, Eric; Shin, Christopher J.; Yao, Jiaqi; Kubo, Tadahiko; Furuta, Taisuke; Oldfield, Eric; Dolbecq, Anne
INORGANIC CHEMISTRY   56(13) 7558-7565   Jul 2017   [Refereed]
We synthesized a series of polyoxometalatebisphosphonate complexes containing Mov106 octahedra, zoledronate, or an N-alkyl (n-C-6 or n-C-8) zoledronate analogue, and in two cases, Mn as a heterometal. Mo6L2 (L = Zol, ZolC(6), ZolC(8)) and MO4L2Mn ...
Value of diffusion-weighted imaging for evaluating chemotherapy response in osteosarcoma: A meta-analysis.
Kubo T, Furuta T, Johan MP, Ochi M, Adachi N.
Mol Clin Oncol.   7(1) 88-92   Jul 2017   [Refereed]
Ameloblastin induces tumor suppressive phenotype and enhances chemosensitivity to doxorubicin via Src-Stat3 inactivation in osteosarcoma.
Ando T, Kudo Y, Iizuka S, Tsunematsu T, Umehara H, Shrestha M, Matsuo T, Kubo T, Shimose S, Arihiro K, Ogawa I, Ochi M, Takata T.
Sci Rep.   5(7) 40187-40187   Jan 2017   [Refereed]
Novel sluggish speed signs on ultrasound is indicative of hemangiomas.
Furuta T, Shimose S, Nakashima Y, Kubo T, Ochi M.
Acta Radiol.   58(10) 1231-1237   Oct 2017   [Refereed]
Kubo, Tadahiko; Furuta, Taisuke; Johan, Muhammad P.; Sakuda, Tomohiko; Ochi, Mitsuo; Adachi, Nobuo
MEDICINE   97(29)    Jul 2018   [Refereed]
Background: Although surgical biopsy has historically been considered to be the standard diagnostic biopsy for soft tissue and bone sarcomas, recent literature suggests that percutaneous core needle biopsy yields similar results. Therefore, an eva...
Urakawa, Hiroshi; Yonemoto, Tsukasa; Matsumoto, Seiichi; Takagi, Tatsuya; Asanuma, Kunihiro; Watanuki, Munenori; Takemoto, Akira; Naka, Norifumi; Matsumoto, Yoshihiro; Kawai, Akira; Kunisada, Toshiyuki; Kubo, Tadahiko; Emori, Makoto; Hiraga, Hiroaki; Hatano, Hiroshi; Tsukushi, Satoshi; Nishida, Yoshihiro; Akisue, Toshihiro; Morii, Takeshi; Takahashi, Mitsuru; Nagano, Akihito; Yoshikawa, Hideki; Sato, Kenji; Kawano, Masanori; Hiraoka, Koji; Tanaka, Kazuhiro; Iwamoto, Yukihide; Ozaki, Toshifumi
WORLD JOURNAL OF SURGICAL ONCOLOGY   16    Aug 2018   [Refereed]
Background: Giant cell tumor of bone (GCTB) is an intermediate tumor known to be locally aggressive, but rarely metastasizing To plan a prospective study of GCTB, we performed a questionnaire survey for institutions participating in the Bone and S...
Metastatic tumor cells detection and anti-metastatic potential with vesicular stomatitis virus in immunocompetent murine model of osteosarcoma.
J Orthop Res.      2018   [Refereed]
Kubo, Tadahiko; Furuta, Taisuke; Sakuda, Tomohiko; Ochi, Mitsuo; Adachi, Nobuo
MEDICINE   97(51)    Dec 2018   [Refereed]
Background: The current standard of chemotherapy response evaluation holds the most important prognostic factor to be the histological assessment of the tumor necrosis of the excised lesion, but the major challenge is to find an early prognostic f...
Johan, Muhammad Phetrus; Kubo, Tadahiko; Furuta, Taisuke; Sakuda, Tomohiko; Adachi, Nobuo
ONCOLOGY LETTERS   17(2) 1969-1973   Feb 2019   [Refereed]
Giant cell tumor of the tendon sheath is a type of slow-growing benign soft tissue tumor that typically arises from the synovium of the tendon sheath. Enchondroma is a benign bone tumor comprising of mature hyaline cartilage that centrally develop...
Sakuda, Tomohiko; Kubo, Tadahiko; Johan, Muhammad Phetrus; Furuta, Taisuke; Sakaguchi, Takemasa; Nakanishi, Mahito; Ochi, Mitsuo; Adachi, Nobuo
JOURNAL OF ORTHOPAEDIC RESEARCH   37(5) 1192-1201   May 2019   [Refereed]
Attempts have been made to visualize tumor cells intraoperatively with fluorescence guidance. However, the clear demarcation and complete tumor resection have always been a challenging task. To address this, we have developed a novel fluorescence ...

Books etc

 
Target Therapy using Magnetic Liposomes
Jun 2002   

Research Grants & Projects

 
Japan Agency for Medical Research and Development: Practical Research for Innovative Cancer Control
Project Year: Apr 2015 - Mar 2016
Project Year: 2014 - 2016
Project Year: 2012 - 2014
MEXT: KAKENHI
Project Year: 2009 - 2011    Investigator(s): KUBO, Tadahiko
Bisphosphonates, widely used to treat a variety of bone resorption diseases, reportedly have some antitumor effects. In this study, we developed novel bisphosphonates for cancer immunotherapy for bone metastasis and, more, Vanadium/ bisphosphonate...
MEXT: KAKENHI
Project Year: 2008 - 2010    Investigator(s): MATSUO, Toshihiro
In this study, we investigated the antitumor effects of telomerase inhibitor TMPyP4 in osteosarcoma cell lines. Both telomerase activity loss and sufficient telomere shortening are necessary to inhibit cell growth in telomerase positive cells. TMP...