Takayama Chitoshi

Profile Information

Affiliation: Professor, Graduate School of Medicine, University of the Ryukyus
: (Concurrent)その他, 医学部
: (Concurrent)Faculty of Medicine

Degree: Doctor of Medical Scinece(Hokkaido University)

J-GLOBAL ID: 200901014394074631
researchmap Member ID: 1000000006

External link

Research Interests

Research Areas

Research History

Apr, 2010 - Present

Department of Molecular Anatomy, University of the Ryukyus Graduate School of Medicine,Professor
Apr, 2007 - Mar, 2010

University of the Ryukyus, Faculty of Medicine, Medicine, Department of Physiological Sciences,Professor
Jan, 2003 - Mar, 2007

Department of Molecular Neuroanatomy, Hokkaido University School of Medicine, Associate Professor
Apr, 2000 - Dec, 2002

Department of Molecular Neuroanatomy, Hokkaido University School of Medicine, Senir Assistant
Nov, 1995 - Mar, 1999

Department of Anatomy, Hokkaido University School of Medicine, Senir Assistant
Apr, 1987 - Oct, 1995

Department of Anatomy, Hokkaido University School of Medicine, Research Assistants

Education

- Mar, 1987

Faculty of Medicine, Keio University

Committee Memberships

Apr, 2009

理事, 西日本医科学生総合体育連盟
Apr, 2007

Scientific Councillor, The Japanese Association of Anatomists
Apr, 2007

評議員, 日本解剖学会
Apr, 2007

専務理事, （公益財団法人）沖縄県医科学研究財団
Apr, 2004

Scientific Councillor, The Japanese Association of Anatomists
Apr, 2004

学術評議員, 日本解剖学会

Papers

Specific Expression of KCC2 in the α Cells of Normal and Type 1 Diabetes Model Mouse Pancreatic Islets

Chigusa Shimizu-Okabe, Shigeki Okada, Shiki Okamoto, Hiroaki Masuzaki, Chitoshi Takayama

ACTA HISTOCHEMICA ET CYTOCHEMICA, 55(1) 47-56, Feb 26, 2022
Developmental Formation of the GABAergic and Glycinergic Networks in the Mouse Spinal Cord.

Chigusa Shimizu-Okabe, Shiori Kobayashi, Jeongtae Kim, Yoshinori Kosaka, Masanobu Sunagawa, Akihito Okabe, Chitoshi Takayama

International journal of molecular sciences, 23(2), Jan 13, 2022
Slow progression of sciatic nerve degeneration and regeneration after loose ligation through microglial activation and decreased KCC2 levels in the mouse spinal cord ventral horn.

Tsukasa Yafuso, Yoshinori Kosaka, Chigusa Shimizu-Okabe, Nobuhiko Okura, Shiori Kobayashi, Jeongtae Kim, Koyata Matsuda, Daichi Kinjo, Akihito Okabe, Chitoshi Takayama

Neuroscience research, Oct 29, 2021
Development and persistence of neuropathic pain through microglial activation and KCC2 decreasing after mouse tibial nerve injury.

Kosaka Y, Yafuso T, Shimizu-Okabe C, Kim J, Kobayashi S, Okura N, Ando H, Okabe A, Takayama C

Brain research, 1733 146718-146718, Apr 15, 2020
Hyper-Formation of GABA and Glycine Co-Releasing Terminals in the Mouse Cerebellar Nuclei after Deprivation of GABAergic Inputs from Purkinje Cells.

Kobayashi S, Kim J, Yanagawa Y, Suzuki N, Saito H, Takayama C

Neuroscience, 426 88-100, Feb 1, 2020
Embryonic development of GABAergic terminals in the mouse hypothalamic nuclei involved in feeding behavior.

Kobayashi M, Shimizu-Okabe C, Kim J, Kobayashi S, Matsushita M, Masuzaki H, Takayama C

Neuroscience research, 134 39-48, Sep, 2018 Peer-reviewed
Changes in the expression and localization of signaling molecules in mouse facial motor neurons during regeneration of facial nerves

Jeongtae Kim, Shiori Kobayashi, Chigusa Shimizu-Okabe, Akihito Okabe, Changjong Moon, Taekyun Shin, Chitoshi Takayama

Journal of Chemical Neuroanatomy, 88 13-21, Mar 1, 2018 Peer-reviewed
Impact of brown rice-specific gamma-oryzanol on epigenetic modulation of dopamine D2 receptors in brain striatum in high-fat-diet-induced obesity in mice

Chisayo Kozuka, Tadashi Kaname, Chigusa Shimizu-Okabe, Chitoshi Takayama, Masato Tsutsui, Masayuki Matsushita, Keiko Abe, Hiroaki Masuzaki

DIABETOLOGIA, 60(8) 1502-1511, Aug, 2017 Peer-reviewed
DISTINCT DEVELOPMENT OF THE GLYCINERGIC TERMINALS IN THE VENTRAL AND DORSAL HORNS OF THE MOUSE CERVICAL SPINAL CORD

Masanobu Sunagawa, Chigusa Shimizu-Okabe, Jeongtae Kim, Shiori Kobayashi, Yoshinori Kosaka, Yuchio Yanagawa, Masayuki Matsushita, Akihito Okabe, Chitoshi Takayama

NEUROSCIENCE, 343 459-471, Feb, 2017 Peer-reviewed
Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of gamma-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice

Chisayo Kozuka, Chigusa Shimizu-Okabe, Chitoshi Takayama, Kaku Nakano, Hidetaka Morinaga, Ayano Kinjo, Kotaro Fukuda, Asuka Kamei, Akihito Yasuoka, Takashi Kondo …

DRUG DELIVERY, 24(1) 558-568, 2017 Peer-reviewed
Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons

Gakuya Takamatsu, Chiaki Katagiri, Tsumuraya Tomoyuki, Chigusa Shimizu-Okabe, Wakako Nakamura, Mariko Nakamura-Higa, Tomoko Hayakawa, Shigeo Wakabayashi, Tsuyoshi Kondo, Chitoshi Takayama …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 482(4) 1327-1333, Jan, 2017 Peer-reviewed
玄米由来機能成分γ-オリザノールによるドパミン受容体シグナルを介するグルコース応答性インスリン分泌増強の新規メカニズム

小塚智沙代, 砂川澄人, 植田玲, 比嘉盛丈, 池間朋己, 田仲秀明, 清水千草, 高山千利, 松下正之, 中田正範 …

糖尿病, 59(Suppl.1) S-457, Apr, 2016
Developmental localization of calcitonin gene-related peptide in dorsal sensory axons and ventral motor neurons of mouse cervical spinal cord

Jeongtae Kim, Masanobu Sunagawa, Shiori Kobayashi, Taekyun Shin, Chitoshi Takayama

NEUROSCIENCE RESEARCH, 105 42-48, Apr, 2016 Peer-reviewed
Developmental and degenerative modulation of GABAergic transmission in the mouse hippocampus

Jinwook Kim, Yeonghoon Son, Juhwan Kim, Sueun Lee, Sohi Kang, Kyunghwan Park, Sung-Ho Kim, Jong-Choon Kim, Jeongtae Kim, Chitoshi Takayama …

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 47(Pt B) 320-332, Dec, 2015 Peer-reviewed
A novel insulinotropic mechanism of whole grain-derived -oryzanol via the suppression of local dopamine D-2 receptor signalling in mouse islet

Chisayo Kozuka, Sumito Sunagawa, Rei Ueda, Moritake Higa, Yuzuru Ohshiro, Hideaki Tanaka, Chigusa Shimizu-Okabe, Chitoshi Takayama, Masayuki Matsushita, Masato Tsutsui …

BRITISH JOURNAL OF PHARMACOLOGY, 172(18) 4519-4534, Sep, 2015
Dietary supplementation with sodium nitrite can exert neuroprotective effects on global cerebral ischemia/reperfusion in mice.

Fukuda T, Kakinohana M, Takayama C, Matsushita M, Sugahara K

Journal of anesthesia, 29(4) 609-17, Aug, 2015 Peer-reviewed
gamma-Oryzanol Protects Pancreatic beta-Cells Against Endoplasmic Reticulum Stress in Male Mice

Chisayo Kozuka, Sumito Sunagawa, Rei Ueda, Moritake Higa, Hideaki Tanaka, Chigusa Shimizu-Okabe, Shogo Ishiuchi, Chitoshi Takayama, Masayuki Matsushita, Masato Tsutsui …

ENDOCRINOLOGY, 156(4) 1242-1250, Apr, 2015
KCC2-mediated regulation of respiration-related rhythmic activity during postnatal development in mouse medulla oblongata

Akihito Okabe, Chigusa Shimizu-Okabe, Akiko Arata, Shiro Konishi, Atsuo Fukuda, Chitoshi Takayama

BRAIN RESEARCH, 1601 31-39, Mar, 2015
Identification of a novel cell-penetrating peptide targeting human glioblastoma cell lines as a cancer-homing transporter.

Moritoshi Higa, Chiaki Katagiri, Chigusa Shimizu-Okabe, Tomoyuki Tsumuraya, Masanori Sunagawa, Mariko Nakamura, Shogo Ishiuchi, Chitoshi Takayama, Eisaku Kondo, Masayuki Matsushita

Biochemical and biophysical research communications, 457(2) 206-12, Feb 6, 2015
Immunohistochemical localization of GABAergic key molecules in the main olfactory bulb of the Korean roe deer, Capreolus pygargus

Jeongtae Kim, Chitoshi Takayama, Changnam Park, Meejung Ahn, Changjong Moon, Taekyun Shin

ACTA HISTOCHEMICA, 117(7) 642-648, 2015 Peer-reviewed

Misc.

wx/ae米は腸内環境を改善し、脂質の排泄を促進する

清水千草, 小林しおり, 佐瀬英俊, 小塚智沙代, 宮崎悠, 新垣正悟, 小倉裕太, 益崎裕章, 高山千利

肥満研究, 23(Suppl.) 208-208, Sep, 2017
Developmental localization of potassium chloride co-transporter 2 (KCC2), GABA and vesicular GABA transporter (VGAT) in the postnatal mouse somatosensory cortex

Chitoshi Takayama, Yoshiro Inoue

NEUROSCIENCE RESEARCH, 67(2) 137-148, Jun, 2010
Developmental localization of potassium chloride co-transporter 2 (KCC2), GABA and vesicular GABA transporter (VGAT) in the postnatal mouse somatosensory cortex

Chitoshi Takayama, Yoshiro Inoue

NEUROSCIENCE RESEARCH, 67(2) 137-148, Jun, 2010
Ontogeny of Cl(-) Homeostasis in Mouse Hypoglossal Nucleus

Akihito Okabe, Akiko Arata, Yoshitaka Oku, Chitoshi Takayama, Atsuo Fukuda

NEW FRONTIERS IN RESPIRATORY CONTROL, 669 29-31, 2010
Ontogeny of Cl(-) Homeostasis in Mouse Hypoglossal Nucleus

Akihito Okabe, Akiko Arata, Yoshitaka Oku, Chitoshi Takayama, Atsuo Fukuda

NEW FRONTIERS IN RESPIRATORY CONTROL, 669 29-31, 2010
CGI-58 Is an alpha/beta-Hydrolase within Lipid Transporting Lamellar Granules of Differentiated Keratinocytes

Masashi Akiyama, Kaori Sakai, Chitoshi Takayama, Teruki Yanagi, Yasuko Yamanaka, James R. McMillan, Hiroshi Shimizu

AMERICAN JOURNAL OF PATHOLOGY, 173(5) 1349-1360, Nov, 2008
CGI-58 Is an α/β-Hydrolase within Lipid Transporting Lamellar Granules of Differentiated Keratinocytes

Masashi Akiyama, Kaori Sakai, Chitoshi Takayama, Teruki Yanagi, Yasuko Yamanaka, James R. McMillan, Hiroshi Shimizu

Am J Pathol., 173(5) 1349-60, 2008 Peer-reviewed
NKCC1 activity modulates formation of functional inhibitory synapses in cultured neocortical neurons

Keiko Nakanishi, Junko Yamada, Chitoshi Takayama, Atsuhiko Oohira, Atsuo Fukuda

SYNAPSE, 61(3) 138-149, Mar, 2007
NKCC1 activity modulates formation of functional inhibitory synapses in cultured neocortical neurons

Keiko Nakanishi, Junko Yamada, Chitoshi Takayama, Atsuhiko Oohira, Atsuo Fukuda

SYNAPSE, 61(3) 138-149, Mar, 2007
Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum

Chitoshi Takayama, Yoshiro Inoue

NEUROSCIENCE RESEARCH, 57(2) 322-325, Feb, 2007
Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum

Chitoshi Takayama, Yoshiro Inoue

Neuroscience Research, 57(2) 322-325, Feb, 2007 Peer-reviewed
Developmental localization of potassium chloride co-transporter 2 in granule cells of the early postnatal mouse cerebellum with special reference to the synapse formation

C. Takayama, Y. Inoue

NEUROSCIENCE, 143(3) 757-767, Dec, 2006
Developmental localization of potassium chloride co-transporter 2 in granule cells of the early postnatal mouse cerebellum with special reference to the synapse formation

C. Takayama, Y. Inoue

NEUROSCIENCE, 143(3) 757-767, Dec, 2006
Formation of GABAergic synapses in the cerebellum

C Takayama

CEREBELLUM, 4(3) 171-177, Sep, 2005
GABAergic signaling in the developing cerebellum.

Takayama C, Inoue Y

Anatomical Science International, 79(3) 124-136, Jun, 2005 Peer-reviewed
Formation of GABAergic synapses in the cerebellum

Takayama C

Cerebellum, 4(2) 171-177, Jun, 2005 Peer-reviewedInvited
Developmental expression of GABA transporter-1 and 3 during formation of the GABAergic synapses in the mouse cerebellar cortex.

Takayama C, Inoue Y

Developmental Brain Research, 158(1-2) 447-458, 2005
Developmental expression of GABA transporter-1 and 3 during formation of the GABAergic synapses in the mouse cerebellar cortex.

Takayama C, Inoue Y

Developmental Brain Research, 158(1-2) 447-458, 2005
GABAergic signaling in the developing cerebellum.

Takayama C, Inoue Y

Anatomical Science International, 79(3) 124-136, 2005
Extrasynaptic localization of GABA in the developing mouse cerebellum

C Takayama, Y Inoue

NEUROSCIENCE RESEARCH, 50(4) 447-458, Dec, 2004

Books and Other Publications

GABAergic signaling in the developing cerebellum. In "GABA in autism and related disorders.(Dhossche D,Ed)"

Takayama C

Academic Press, Jan, 2005

Professional Memberships

Research Projects

GABA/グリシンの興奮性応答を介した神経再生カスケードの解析と治療法への応用

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

高山千利, 清水千草
Relationship between GABA release and GABAergic action in the spinal cord to the development of fetal motor function

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2022

Chigusa Shimizu
Investigation of the therapeutics for neuropathic pain through GABAergic transmission

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Takayama Chitoshi
Molecular mechanism of addiction to animal fat and therapeutic potential of brown rice-specific bioactive substance, gamma-oryzanol for animal fat preference

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2019

Masuzaki Hiroaki
Mechanisms of developing food preference and memorization (learning) through exposure to high-fat diets or sweeteners early in life

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2017

YABIKU Kouichi
GABAergic signalinng.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

TAKAYAMA CHITOSHI, YANAGAWA Yuchio, SHIMIZU Chigusa
The formation of GABAergic network and rhyhm of repiratory in the embryonic development

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

SHIMIZU Chigusa, OKABE Akihito, TAKAYAMA Chitoshi, YANAGAWA Yuchio
Exploration of novel hypothalamic mechanism on fatty food preference and its application to clinical science on obesity-diabetes syndrome

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

MASUZAKI Hiroaki, TAKAYAMA Chitoshi, SHIMABUKURO Michio, MATUSHITA Masayuki, KOZUKA Chisayo
Morphological analysis of the GABA function using knockout mice lacking of molecules involved in GABAergic signaling

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2013

TAKAYAMA Chitoshi, YANAGAWA Yuchio, OKABE Akihito
Exposure to Artificial Sweetener in Juvenile Mice Intensifies Addictionto High-Fat Diet and Exaggerates Leptin Resistance in Adulthood

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

YABIKU Kouichi, MASUZAKI Hiroaki, TAKAYAMA Chitoshi, SHIMABUKURO Michio, KOUKI Tsuyoshi
神経系の発生、発達、再生過程におけるGABAシグナルの変化

科学研究費助成事業, 基盤研究(C), 日本学術振興会, 2009 - 2010

高山千利
Changes in GABA signaling during development and regeneration

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

TAKAYAMA Chitoshi
神経系の発生、発達、再生過程におけるGABAシグナルの変化

科学研究費助成事業, 基盤研究(C), 日本学術振興会, 2010

高山千利
Inhibitory factors of central myelin formation-on the basis of comparative and developmental study on the lemma cribrosa sclerae of the optic nerve

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2002 - 2003

INOUE Yoshiro, IKENAKA Kazuhiro, TAKAYAMA Chitoshi
Glial role in neuronal development and function

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas (B), Japan Society for the Promotion of Science, 1998 - 2001

WATANABE Masahiko
小脳における抑制性神経回路網の形成および維持調節機構の形態学的解析

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1999 - 2000

高山千利
小脳皮質における抑制性神経回路網の発生とGABA_A受容体の発現変化

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1997 - 1998

高山千利
ANALYSIS Of FUNCTIONAL MECHAMISM OF GLUTAMATE RECEPTORS IN NEURO-LOGICAL MUTANT MICE BY PHOTOMETRIC SYSTEM.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1995 - 1997

INOUE Yoshiro, ICHIKAWA Ryoichi, NAGASHIMA Masabumi, TAKAYAMA Chitoshi, WATANABE Masahiko
Alteration of neuronal network in the central nervous system of a dystonic mutant mouse, "Wriggle mouse Sagami"

Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, 1990 - 1991

INOUE Yoshiro, TAKAYAMA Chitoshi
遺伝性dystomicマウスWriggle Mouse Sagamiの病態解明

科学研究費助成事業, 一般研究(C), 日本学術振興会, 1989 - 1989

井上芳郎, 高山千利

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