2019年
NMRを用いたG蛋白質共役型受容体の機能制御メカニズムの解析
生物物理
- ,
- 巻
- 59
- 号
- 4
- 開始ページ
- 181
- 終了ページ
- 187
- 記述言語
- 日本語
- 掲載種別
- DOI
- 10.2142/biophys.59.181
- 出版者・発行元
- 一般社団法人 日本生物物理学会
<p>GPCRs function as receptors for various neurotransmitters and hormones, and >30% of current drugs target GPCRs. Although substantial number of GPCR crystal structures have become available, information about GPCR features can only be partially derived from the crystallography data. NMR methods provide information about dynamics of GPCRs over a wide range of frequencies in aqueous media at near-physiological temperature, with minimal modification of the wild-type GPCR covalent structures. Here we review our recent NMR studies of the function-related conformational equilibria of GPCRs, including β<sub>2</sub> adrenergic receptor and μ opioid receptor.</p>
- リンク情報
- ID情報
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- DOI : 10.2142/biophys.59.181
- ISSN : 0582-4052
- eISSN : 1347-4219
- CiNii Articles ID : 130007683541
- CiNii Books ID : AN00129693
- identifiers.cinii_nr_id : 9000403403142
- CiNii Research ID : 1390845713084677120