Satoshi Tanaka

J-GLOBAL         Last updated: Jan 15, 2020 at 16:05
 
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Name
Satoshi Tanaka
E-mail
asatoshimail.ecc.u-tokyo.ac.jp
Research funding number
90242164

Research Areas

 
 

Academic & Professional Experience

 
Apr 1995
 - 
Mar 1998
Postdoctoral Fellow, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto
 

Education

 
Apr 1982
 - 
Mar 1986
Department of Biology, Faculty of Science, Tohoku University
 

Awards & Honors

 
Sep 1996
Rochester Trophoblast Conference Young Investigator Award, IFPA
 

Published Papers

 
Kiyozumi, D., Nakano, I., Sato-Nishiuchi, R., Tanaka, S. and Sekiguchi, K
Life Sci Alliance   3(2) e201900515   Jan 2020   [Refereed]
Tomikawa, J., Takada, S., Okamura, K., Terao, M., Ogata-Kawata, H., Akutsu, H., Tanaka, S., Hata, K., Nakabayashi, K
Nucleic Acids Res   48(1) 278-289   Jan 2020   [Refereed]
Published online
Hayakawa K, Terada K, Takahashi T, Oana H, Washizu M, Tanaka S
Scientific reports   8(1) 5811   Apr 2018   [Refereed]
Hayakawa K, Hirosawa M, Tani R, Yoneda C, Tanaka S, Shiota K
Epigenetics & chromatin   10(1) 51   Oct 2017   [Refereed]
Hirosawa M, Hayakawa K, Yoneda C, Arai D, Shiota H, Suzuki T, Tanaka S, Dohmae N, Shiota K
Scientific reports   6 31785   Sep 2016   [Refereed]
Tani R, Hayakawa K, Tanaka S, Shiota K
Epigenetics   11(4) 288-302   Apr 2016   [Refereed]
Arai Daisuke, Hayakawa Koji, Ohgane Jun, Hirosawa Mitsuko, Nakao Yoichi, Tanaka Satoshi, Shiota Kunio
MECHANISMS OF DEVELOPMENT   136 143-154   May 2015   [Refereed]
Okae H, Matoba S, Nagashima T, Mizutani E, Inoue K, Ogonuki N, Chiba H, Funayama R, Tanaka S, Yaegashi N, Nakayama K, Sasaki H, Ogura A, Arima T
Human molecular genetics   23(4) 992-1001   Feb 2014   [Refereed]
Oikawa M, Inoue K, Shiura H, Matoba S, Kamimura S, Hirose M, Mekada K, Yoshiki A, Tanaka S, Abe K, Ishino F, Ogura A
Epigenetics   9(2) 204-211   Feb 2014   [Refereed]
Hayakawa Koji, Hirosawa Mitsuko, Tabei Yasuyuki, Arai Daisuke, Tanaka Satoshi, Murakami Noboru, Yagi Shintaro, Shiota Kunio
JOURNAL OF BIOLOGICAL CHEMISTRY   288(24) 17099-17110   Jun 2013   [Refereed]
Hayakawa K, Ohgane J, Tanaka S, Yagi S, Shiota K
Epigenetics   7(9) 1029-1036   Sep 2012   [Refereed]
Hayakawa K, Nakanishi MO, Ohgane J, Tanaka S, Hirosawa M, Soares MJ, Yagi S, Shiota K
Mammalian genome : official journal of the International Mammalian Genome Society   23(5-6) 336-345   Jun 2012   [Refereed]
Tomikawa J, Uenoyama Y, Ozawa M, Fukanuma T, Takase K, Goto T, Abe H, Ieda N, Minabe S, Deura C, Inoue N, Sanbo M, Tomita K, Hirabayashi M, Tanaka S, Imamura T, Okamura H, Maeda K, Tsukamura H
Proceedings of the National Academy of Sciences of the United States of America   109(20) E1294-301   May 2012   [Refereed]
Okae H, Hiura H, Nishida Y, Funayama R, Tanaka S, Chiba H, Yaegashi N, Nakayama K, Sasaki H, Arima T
Human molecular genetics   21(3) 548-558   Feb 2012   [Refereed]
Nakanishi MO, Hayakawa K, Nakabayashi K, Hata K, Shiota K, Tanaka S
Epigenetics   7(2) 173-182   Feb 2012   [Refereed]
Nishino K, Hattori N, Sato S, Arai Y, Tanaka S, Nagy A, Shiota K
The Journal of reproduction and development   57(5) 586-593   Oct 2011   [Refereed]
Sato S, Maeda C, Hattori N, Yagi S, Tanaka S, Shiota K
The Journal of reproduction and development   57(4) 526-533   Sep 2011   [Refereed]
Muramoto H, Yagi S, Hirabayashi K, Sato S, Ohgane J, Tanaka S, Shiota K
Genes to cells : devoted to molecular & cellular mechanisms   15(8) 855-865   Aug 2010   [Refereed]
Sato S, Yagi S, Arai Y, Hirabayashi K, Hattori N, Iwatani M, Okita K, Ohgane J, Tanaka S, Wakayama T, Yamanaka S, Shiota K
Genes to cells : devoted to molecular & cellular mechanisms   15(6) 607-618   Jun 2010   [Refereed]
Hayashi Y, Furue MK, Tanaka S, Hirose M, Wakisaka N, Danno H, Ohnuma K, Oeda S, Aihara Y, Shiota K, Ogura A, Ishiura S, Asashima M
In vitro cellular & developmental biology. Animal   46(5) 416-430   May 2010   [Refereed]
Lim HW, Iwatani M, Hattori N, Tanaka S, Yagi S, Shiota K
The Journal of reproduction and development   56(1) 86-93   Feb 2010   [Refereed]
Murohashi M, Nakamura T, Tanaka S, Ichise T, Yoshida N, Yamamoto T, Shibuya M, Schlessinger J, Gotoh N
Stem cells (Dayton, Ohio)   28(1) 113-121   Jan 2010   [Refereed]
Oda M, Tanaka S, Yamazaki Y, Ohta H, Iwatani M, Suzuki M, Ohgane J, Hattori N, Yanagimachi R, Wakayama T, Shiota K
Proceedings of the National Academy of Sciences of the United States of America   106(38) 16293-16297   Sep 2009   [Refereed]
Ogawa H., Shindo N., Kumagai T., Usami Y., Shikanai M., Jonwn K., Fukuda A., Kawahara M., Sotomaru Y., Tanaka S., Arima T., Kono T.
PLACENTA   30(5) 448-456   May 2009   [Refereed]
Yagi S, Hirabayashi K, Sato S, Li W, Takahashi Y, Hirakawa T, Wu G, Hattori N, Hattori N, Ohgane J, Tanaka S, Liu XS, Shiota K
Genome research   18(12) 1969-1978   Dec 2008   [Refereed]
Watanabe K, Tachibana M, Tanaka S, Furuoka H, Horiuchi M, Suzuki H, Watarai M
BMC microbiology   8 212   Dec 2008   [Refereed]
Takahashi Y, Takahashi M, Carpino N, Jou ST, Chao JR, Tanaka S, Shigeyoshi Y, Parganas E, Ihle JN
Molecular endocrinology (Baltimore, Md.)   22(7) 1673-1681   Jul 2008   [Refereed]
Maeda Chiaki, Sato Shun, Hattori Naoko, Tanaka Satoshi, Yagi Shintaro, Shiota Kunio
BIOLOGY OF REPRODUCTION   78(5) 816-821   May 2008   [Refereed]
Sakamoto Hideki, Kogo Yasushi, Ohgane Jun, Hattori Naka, Yagi Shintaro, Tanaka Satoshi, Shiota Kunio
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   366(2) 360-366   Feb 2008   [Refereed]
Suzuki Masako, Sato Shun, Arai Yoshikazu, Shinohara Takashi, Tanaka Satoshi, Greally John M., Hattori Naka, Shiota Kunio
GENES TO CELLS   12(12) 1305-1314   Dec 2007   [Refereed]
Sakamoto Hideki, Suzuki Masako, Abe Tetsuya, Hosoyama Tohru, Himeno Emi, Tanaka Satoshi, Greally John M., Hattori Naka, Yagi Shintaro, Shiota Kunio
GENES TO CELLS   12(10) 1123-1132   Oct 2007   [Refereed]
Hattori N, Imao Y, Nishino K, Hattori N, Ohgane J, Yagi S, Tanaka S, Shiota K
Genes to cells : devoted to molecular & cellular mechanisms   12(3) 387-396   Mar 2007   [Refereed]
Hamada Y, Hiroe T, Suzuki Y, Oda M, Tsujimoto Y, Coleman JR, Tanaka S
Differentiation; research in biological diversity   75(3) 268-278   Mar 2007   [Refereed]
Nakamura Toshinobu, Arai Yoshikazu, Umehara Hiroki, Masuhara Masaaki, Kimura Tohru, Taniguchi Hisaaki, Sekimoto Toshihiro, Ikawa Masahito, Yoneda Yoshihiro, Okabe Masaru, Tanaka Satoshi, Shiota Kunio, Nakano Toru
NATURE CELL BIOLOGY   9(1) 64-U81   Jan 2007   [Refereed]
Ikegami Kohta, Iwatani Misa, Suzuki Masako, Tachibana Makoto, Shinkai Yoichi, Tanaka Satoshi, Greally John M., Yagi Shintaro, Hattori Naka, Shiota Kunio
GENES TO CELLS   12(1) 1-11   Jan 2007   [Refereed]
Senda Sho, Wakayama Teruhiko, Arai Yoshikazu, Yamazaki Yukiko, Ohgane Jun, Tanaka Satoshi, Hattori Naka, Yanagimachi Ryuzo, Shiota Kunio
CLONING AND STEM CELLS   9(3) 293-302   2007   [Refereed]
Iwatani Misa, Ikegami Kohta, Kremenska Yuliya, Hattori Naka, Tanaka Satoshi, Yagi Shintaro, Shiota Kunio
STEM CELLS   24(11) 2549-2556   Nov 2006   [Refereed]
Wakayama Sayaka, Jakt Martin L., Suzuki Masako, Araki Ryoko, Hikichi Takafusa, Kishigami Satoshi, Ohta Hiroshi, Van Thuan Nguyen, Mizutani Eiji, Sakaide Yuko, Senda Sho, Tanaka Satoshi, Okada Mitsuhiro, Miyake Masashi, Abe Masumi, Nishikawa Shin-Ichi, Shiota Kunio, Wakayama Teruhiko
STEM CELLS   24(9) 2023-2033   Sep 2006   [Refereed]
Arima T, Hata K, Tanaka S, Kusumi M, Li E, Kato K, Shiota K, Sasaki H, Wake N
Developmental biology   297(2) 361-373   Sep 2006   [Refereed]
Yamada K, Kanda H, Tanaka S, Takamatsu N, Shiba T, Ito M
Differentiation; research in biological diversity   74(5) 212-221   Jun 2006   [Refereed]
Sun W, Kimura H, Hattori N, Tanaka S, Matsuyama S, Shiota K
Biochemical and biophysical research communications   342(3) 817-823   Apr 2006   [Refereed]
Tomikawa J, Fukatsu K, Tanaka S, Shiota K
The Journal of biological chemistry   281(17) 12163-12169   Apr 2006   [Refereed]
Nakamura Y, Hamada Y, Fujiwara T, Enomoto H, Hiroe T, Tanaka S, Nose M, Nakahara M, Yoshida N, Takenawa T, Fukami K
Molecular and cellular biology   25(24) 10979-10988   Dec 2005   [Refereed]
Gotoh N, Manova K, Tanaka S, Murohashi M, Hadari Y, Lee A, Hamada Y, Hiroe T, Ito M, Kurihara T, Nakazato H, Shibuya M, Lax I, Lacy E, Schlessinger J
MOLECULAR AND CELLULAR BIOLOGY   25(10) 4105-4116   May 2005   [Refereed]
Ko YG, Nishino K, Hattori N, Arai Y, Tanaka S, Shiota K
The Journal of biological chemistry   280(10) 9627-9634   Mar 2005   [Refereed]
Hiratsuka S, Kataoka Y, Nakao K, Nakamura K, Morikawa S, Tanaka S, Katsuki M, Maru Y, Shibuya M
Molecular and cellular biology   25(1) 355-363   Jan 2005   [Refereed]
Imamura T, Miyauchi-Senda N, Tanaka S, Shiota K
The Journal of veterinary medical science   66(11) 1387-1393   Nov 2004   [Refereed]
Imamura T, Yamamoto S, Ohgane J, Hattori N, Tanaka S, Shiota K
Biochemical and biophysical research communications   322(2) 593-600   Sep 2004   [Refereed]
Senda S, Wakayama T, Yamazaki Y, Ohgane J, Hattori N, Tanaka S, Yanagimachi R, Shiota K
Biochemical and biophysical research communications   321(1) 38-44   Aug 2004   [Refereed]
Min KS, Hiyama T, Seong HH, Hattori N, Tanaka S, Shiota K
The Journal of reproduction and development   50(3) 297-304   Jun 2004   [Refereed]
Singh U, Fohn LE, Wakayama T, Ohgane J, Steinhoff C, Lipkowitz B, Schulz R, Orth A, Ropers HH, Behringer RR, Tanaka S, Shiota K, Yanagimachi R, Nuber UA, Fundele R
Developmental dynamics : an official publication of the American Association of Anatomists   230(1) 149-164   May 2004   [Refereed]
Nishino K, Hattori N, Tanaka S, Shiota K
The Journal of biological chemistry   279(21) 22306-22313   May 2004   [Refereed]
Hattori N, Nishino K, Ko YG, Hattori N, Ohgane J, Tanaka S, Shiota K
The Journal of biological chemistry   279(17) 17063-17069   Apr 2004   [Refereed]
Ohgane J, Wakayama T, Senda S, Yamazaki Y, Inoue K, Ogura A, Marh J, Tanaka S, Yanagimachi R, Shiota K
Genes to cells : devoted to molecular & cellular mechanisms   9(3) 253-260   Mar 2004   [Refereed]
Kremenskoy M, Kremenska Y, Ohgane J, Hattori N, Tanaka S, Hashizume K, Shiota K
Biochemical and biophysical research communications   311(4) 884-890   Nov 2003   [Refereed]
Sekiguchi S, Yoshikawa Y, Tanaka S, Kwon J, Ishii Y, Kyuwa S, Wada K, Nakamura S, Takahashi K
Experimental animals   52(4) 365-369   Jul 2003   [Refereed]
Kimura H, Nakamura T, Ogawa T, Tanaka S, Shiota K
Nucleic acids research   31(12) 3101-3113   Jun 2003   [Refereed]
Shiota K, Kogo Y, Ohgane J, Imamura T, Urano A, Nishino K, Tanaka S, Hattori N
Genes to cells : devoted to molecular & cellular mechanisms   7(9) 961-969   Sep 2002   [Refereed]
Ohgane J, Hattori N, Oda M, Tanaka S, Shiota K
Biochemical and biophysical research communications   290(2) 701-706   Jan 2002   [Refereed]
Saneyoshi T, Min KS, Jing Ma X, Nambo Y, Hiyama T, Tanaka S, Shiota K
Biology of reproduction   65(6) 1686-1690   Dec 2001   [Refereed]
Tanaka S, Oda M, Toyoshima Y, Wakayama T, Tanaka M, Yoshida N, Hattori N, Ohgane J, Yanagimachi R, Shiota K
Biology of reproduction   65(6) 1813-1821   Dec 2001   [Refereed]
Oda M, Sun W, Hattori N, Tanaka S, Shiota K
Biochemical and biophysical research communications   287(3) 721-726   Sep 2001   [Refereed]
Cho JH, Kimura H, Minami T, Ohgane J, Hattori N, Tanaka S, Shiota K
Endocrinology   142(8) 3389-3396   Aug 2001   [Refereed]
Imamura T, Ohgane J, Ito S, Ogawa T, Hattori N, Tanaka S, Shiota K
Genomics   76(1-3) 117-125   Aug 2001   [Refereed]
Yan J, Tanaka S, Oda M, Makino T, Ohgane J, Shiota K
Developmental biology   235(2) 422-432   Jul 2001   [Refereed]
Ohgane J, Wakayama T, Kogo Y, Senda S, Hattori N, Tanaka S, Yanagimachi R, Shiota K
Genesis (New York, N.Y. : 2000)   30(2) 45-50   Jun 2001   [Refereed]
Ishimura R, Yoshida K, Kimura H, Dohmae N, Takio K, Ogawa T, Tanaka S, Shiota K
Molecular and cellular endocrinology   174(1-2) 77-89   Mar 2001   [Refereed]
Sun W, Hattori N, Mutai H, Toyoshima Y, Kimura H, Tanaka S, Shiota K
Biochemical and biophysical research communications   280(4) 1048-1054   Feb 2001   [Refereed]
Mutai H, Toyoshima Y, Sun W, Hattori N, Tanaka S, Shiota K
Biochemical and biophysical research communications   274(2) 427-433   Aug 2000   [Refereed]
Iwatsuki K, Shinozaki M, Sun WY, Yagi S, Tanaka S, Shiota K
BIOLOGY OF REPRODUCTION   62(5) 1352-1359   May 2000   [Refereed]
Kubota N, Terauchi Y, Miki H, Tamemoto H, Yamauchi T, Komeda K, Satoh S, Nakano R, Ishii C, Sugiyama T, Eto K, Tsubamoto Y, Okuno A, Murakami K, Sekihara H, Hasegawa G, Naito M, Toyoshima Y, Tanaka S, Shiota K, Kitamura T, Fujita T, Ezaki O, Aizawa S, Kadowaki T
Molecular cell   4(4) 597-609   Oct 1999   [Refereed]
Hirosawa-Takamori, M., Matsuura, Y., Tanaka, S., Ogawa, T. and Shiota, K.
Journal of Reproduction and Development   45 43-50   1999   [Refereed]
Tanaka S, Kunath T, Hadjantonakis AK, Nagy A, Rossant J
Science (New York, N.Y.)   282(5396) 2072-2075   Dec 1998   [Refereed]
Kimura H, Takeda T, Tanaka S, Ogawa T, Shiota K
Biochemical and biophysical research communications   253(2) 495-501   Dec 1998   [Refereed]
Iwatsuki K, Oda M, Sun WY, Tanaka S, Ogawa T, Shiota K
ENDOCRINOLOGY   139(12) 4976-4983   Dec 1998   [Refereed]
Wilms' tumor suppressor gene (WT1) as a target gene of SRY function in a mouse ES cell line transfected with SRY.
Toyooka Y, Tanaka SS, Hirota O, Tanaka S, Takagi N, Yamanouchi K, Tojo H, Tachi C
The International journal of developmental biology   42(8) 1143-1151   Nov 1998   [Refereed]
Functions of the N-glycans of rat leukemia inhibitory factor expressed in Chinese hamster ovary cells.
Sasai K, Aikawa Ji, Saburi S, Tojo H, Tanaka S, Ogawa T, Shiota K
Journal of biochemistry   124(5) 999-1003   Nov 1998   [Refereed]
Hattori N, Nukada T, Oda M, Tanaka S, Ogawa T, Shiota K
Endocrine journal   45(5) 659-674   Oct 1998   [Refereed]
Kano, K., Tojo, H., Yamanouchi, K., Soeta, C., Tanaka, S., Ishii, S. and Tachi, C.
Journal of Reproduction and Development   44(3) 253-260   1998   [Refereed]
Tanaka S, Yanagisawa N, Tojo H, Kim YJ, Tsujimura T, Kitamura Y, Sawasaki T, Tachi C
Biochimica et biophysica acta   1352(2) 151-155   May 1997   [Refereed]
Seo BB, Kim CH, Tojo H, Tanaka S, Yamanouchi K, Takahashi M, Sawasaki T, Tachi C
Reproduction, fertility, and development   9(2) 263-269   1997   [Refereed]
Quantitative analysis of striped coat-color patterns in Large White-->Duroc chimeric pigs with special reference to the genetic control mechanisms of the dominant black-eyed white phenotype.
Inoué K, Tanaka S, Kashiwazaki N, Nakao H, Nakatsuji N, Sakaki N, Tojo H, Tachi C
Pigment cell research   9(6) 289-297   Dec 1996   [Refereed]
Quantitative analysis of the spreading of the mouse trophoblast in vitro: a model for early invasion.
Suenaga A, Tachi C, Tojo H, Tanaka S, Tsutsumi O, Taketani Y
Placenta   17(8) 583-590   Nov 1996   [Refereed]
Wen J, Kawamata Y, Tojo H, Tanaka S, Tachi C
Molecular reproduction and development   41(4) 399-406   Aug 1995   [Refereed]
Tanaka S, Tojo H, Kasai K, Sawasaki T, Tachi C
Pigment cell research   7(3) 152-157   Jun 1994   [Refereed]
Expression of tyrosinase gene in transgenic albino mice: the heritable patterned coat colors.
Tanaka S, Takeuchi T
Pigment cell research   5(5 Pt 2) 300-303   Nov 1992   [Refereed]
Conserved regulatory mechanisms of tyrosinase genes in mice and humans.
Tanaka M, Tanaka S, Miura H, Yamamoto H, Kikuchi H, Takeuchi T
Pigment cell research   5(5 Pt 2) 304-311   Nov 1992   [Refereed]
Phylogeny of regulatory regions of vertebrate tyrosinase genes.
Yamamoto H, Kudo T, Masuko N, Miura H, Sato S, Tanaka M, Tanaka S, Takeuchi S, Shibahara S, Takeuchi T
Pigment cell research   5(5 Pt 2) 284-294   Nov 1992   [Refereed]
Tanaka S, Yamamoto H, Takeuchi S, Takeuchi T
Development (Cambridge, England)   108(2) 223-227   Feb 1990   [Refereed]

Misc

 
Hirosawa, M., Hayakawa, K., Shiota, K. and Tanaka, S.
OBM Genetics   2(3) 036   Sep 2018   [Refereed]
Hayakawa K, Himeno E, Tanaka S, Kunath T
Current protocols in stem cell biology   32 1E.4.1-32   Feb 2015   [Refereed]
Tanaka S, Nakanishi MO, Shiota K
The International journal of developmental biology   58(2-4) 231-238   2014   [Refereed]
中西もも, 田中智
臨床婦人科産科   65(3) 260-265   Mar 2011
Oda M, Shiota K, Tanaka S
Development, growth & differentiation   52(3) 285-291   Apr 2010   [Refereed]

Books etc

 
Croy B. A. (B. Anne), Yamada Aureo T., DeMayo Francesco J., Adamson S. Lee (Part:Contributor, Epigenetics of Placental Development and Function)
Elsevier   2014   ISBN:9780123944450
Stem Cell Biology (Cold Spring Harbor Monograph Series, 40)
Daniel R. Marshak (Author, Editor), Richard L. Gardner (Editor), David Gottlieb (Editor) (Part:Contributor, Trophoblast Stem Cells.)
Cold Spring Harbor Laboratory Press   Feb 2001   ISBN:9780879695750

Conference Activities & Talks

 
TANI Ruiko, HAYAKAWA Koji, TANAKA Satoshi, SHIOTA Kunio
The Journal of Reproduction and Development Supplement   2015   
リンカーヒストンH1のバリアントの一つであるH1Tは,精子形成過程中の精母細胞から精細胞の段階で高い発現を示す。最近の研究で我々は,卵子特異的なバリアントであるH1fooがクロマチン構造を弛緩させるという,これまで報告されていた体細胞型H1の機能とは逆の働きを有していること,また強制発現によりマウスES細胞の分化を阻害することを明らかにした。このことから,生殖細胞型H1には体細胞型とは異なった機能やゲノム標的領域を持つことが示唆される。そこで本研究では生殖細胞特異的H1の一つであるH1Tに...
田中智
日本絨毛性疾患研究会・日本胎盤学会学術集会プログラム・抄録集   2015   
YAMASHITA Midori, ARAI Yoshikazu, ITO Shuhei, OHGANE Jun, HIROSAWA-TAKAMORI Mitsuko, TANAKA Satoshi, YAGI Shintaro, SHIOTA Kunio
The Journal of Reproduction and Development Supplement   2011   
GSK3 (glycogen synthase kinase 3) はセリン/スレオニンリン酸化酵素で、インスリンやIGF等の様々なシグナル経路の中心酵素である。マウスでは、2つのアイソフォーム(GSK3a,b)が存在し、Gsk3ダブルノックアウトにより、ES細胞からのEB (embryoid body) 形成能が失われることが報告されている。遺伝子の少ない領域や転写が不活性な領域に存在するゲノム凝集状態を反映した動的な構造であるヘテロクロマチンの構築はES細胞の分化過程にお...
Abe Yukiko, Hayakawa Koji, Hirosawa-Takamori Mitsuko, Yagi Shintaro, Tanaka Satoshi, Shiota Kunio
The Journal of Reproduction and Development Supplement   2011   
マウス初期胚における核O-GlcNAcシグナル マウス初期胚では8細胞期以降で解糖系が機能し,グルコースを主なエネルギー源とした発生が進行する。胚の体外発生では培地中のグルコース除去及び高濃度グルコースは胚盤胞期胚への到達や正常な形態形成を阻害する。グルコース代謝経路の一つであるヘキソサミン合成経路において,O結合型N-アセチルグルコサミン(O-GlcNAc)修飾の基質であるUDP-GlcNAcはグルコースから合成され,O-GlcNAc転移酵素(Ogt)によりタンパク質へと付加される。O-...
Hayakawa Koji, Ohgane Jun, Tanaka Satoshi, Shiota Kunio, Yagi Shinntaro
The Journal of Reproduction and Development Supplement   2011   
哺乳動物のゲノム上には組織・細胞種依存的なメチル化可変領域(T-DMR)が多数存在し、T-DMRのメチル化・非メチル化の組み合わせであるDNAメチル化プロフィールは細胞種固有の機能発現に重要な役割を果たしている。ヒストンH1ファミリーに属するH1fooは、卵核胞期から受精後2細胞前期までの限られた時期・細胞のみで発現する。H1fooは T-DMRを有し、雌性生殖細胞系列でのみ脱メチル化され、体細胞および雄性生殖細胞系列ではDNAメチル化によって発現が抑制されている。H1fooは体細胞核のリ...