Tetsuro Marunouchi

Profile Information

Affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

J-GLOBAL ID: 201801020972342946
researchmap Member ID: B000341797

Research Interests

Research Areas

Life sciences / Pharmacology /

Research History

2020 - Present

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
2015 - 2020

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
2009 - 2015

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

Education

Committee Memberships

- Present

学術評議員, 日本薬理学会

Awards

Mar, 2024

水島昭二記念研究賞, 東京薬科大学

丸ノ内徹郎
Mar, 2022

学生優秀発表賞（ポスター発表の部）, 駆出率が保持された心不全（HFpEF）モデルの作製と各種パラメーターの評価, 日本薬学会第142年会

高橋きらら, 喬立娜, 内田愛美, 並木俊輔, 丸ノ内徹郎, 田野中浩一
Aug, 2021

優秀発表賞, 心筋リモデリングでのHsp90の役割の解明と新規治療法への応用, 日本薬学会薬理系薬学部会生体機能と創薬シンポジウム 2021

丸ノ内徹郎
2018

優秀発表賞, 第 138 回日本薬理学会関東部会

小川惟弘,小林拓也,丸ノ内徹郎,田野中浩一
2011

優秀発表賞, 第13回応用薬理シンポジウム

武藤千晶,丸ノ内徹郎,高木教夫,竹尾聰,田野中浩一

Papers

Angiotensin II Is Involved in MLKL Activation During the Development of Heart Failure Following Myocardial Infarction in Rats

Tetsuro Marunouchi, Sumika Onda, Minami Kurasawa, Kouichi Tanonaka

Biological and Pharmaceutical Bulletin, 47(4) 809-817, Apr 6, 2024 Peer-reviewedLead author
Simvastatin Attenuates Cardiac Fibrosis under Pathophysiological Conditions of Heart Failure with Preserved Left Ventricular Ejection Fraction by Inhibiting TGF-β Signaling.

Tetsuro Marunouchi, Kasumi Matsumura, Eriko Fuji, Akihiro Iwamoto, Kouichi Tanonaka

Pharmacology, 109(1) 43-51, 2024 Peer-reviewedLead author
Involvement of Hsp90 in NLRP3 inflammasome activation in the failing heart following myocardial infarction in rats.

Tetsuro Marunouchi, Aika Iguchi, Aono Shindo, Nana Shimbo, Emi Yano, Kouichi Tanonaka

Biochemical pharmacology, 212 115547-115547, Jun, 2023 Peer-reviewedLead author
Simvastatin attenuates the c-Raf/Erk and calcineurin-NFATc2 pathways via inhibition of Hsp90 activity during the development of heart failure.

Tetsuro Marunouchi, Kyo Fujita, Kirara Takahashi, Shunsuke Namiki, Lina Kyo, Manami Uchida, Emi Yano, Kouichi Tanonaka

Journal of Pharmacological Sciences, Nov, 2022 Peer-reviewedLead author
Hsp90 Inhibitor Attenuates the Development of Pathophysiological Cardiac Fibrosis in Mouse Hypertrophy via Suppression of the Calcineurin-NFAT and c-Raf-Erk Pathways.

Tetsuro Marunouchi, Miyuki Nakashima, Saika Ebitani, Sakiko Umezu, Kasane Karasawa, Emi Yano, Kouichi Tanonaka

Journal of cardiovascular pharmacology, 77(6) 822-829, Jun 1, 2021 Peer-reviewedLead author
Effects of Hsp90 inhibitor on the RIP1-RIP3-MLKL pathway during the development of heart failure in mice.

Tetsuro Marunouchi, Chiharu Nishiumi, Saki Iinuma, Emi Yano, Kouichi Tanonaka

European journal of pharmacology, 898 173987-173987, May 5, 2021 Peer-reviewedLead author
Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats

Tetsuro Marunouchi, Takumi Ito, Sumika Onda, Lina Kyo, Kirara Takahashi, Manami Uchida, Emi Yano, Kouichi, Tanonaka

Journal of Pharmacological Sciences, 147(2) 192-199, 2021 Peer-reviewedLead author
Transplantation of cardiac Sca-1-positive cells rather than c-Kit-positive cells preserves mitochondrial oxygen consumption of the viable myocardium following myocardial infarction in rats.

Tetsuro Marunouchi, Kyohei Sasaki, Emi Yano, Kouichi Tanonaka

Journal of pharmacological sciences, 140(3) 236-241, Jul, 2019 Peer-reviewedLead author
Histone Deacetylase Inhibitor SAHA Treatment Prevents the Development of Heart Failure after Myocardial Infarction via an Induction of Heat-Shock Proteins in Rats.

Shiho Nagata, Tetsuro Marunouchi, Kouichi Tanonaka

Biological & pharmaceutical bulletin, 42(3) 453-461, Mar 1, 2019 Peer-reviewed
Heat-shock protein 90 modulates cardiac ventricular hypertrophy via activation of MAPK pathway.

Shoko Tamura, Tetsuro Marunouchi, Kouichi Tanonaka

Journal of molecular and cellular cardiology, 127 134-142, Feb, 2019 Peer-reviewed
Effects of cardiosphere-derived cell transplantation on cardiac mitochondrial oxygen consumption after myocardial infarction in rats.

Tetsuro Marunouchi, Emi Yano, Kouichi Tanonaka

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 108 883-892, Dec, 2018 Peer-reviewedLead author
[Angiotensin-converting enzyme 2].

Kouichi Tanonaka, Tetsuro Marunouchi

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 147(2) 120-1, Feb, 2016 Peer-reviewedInvited
Cell Death in the Cardiac Myocyte.

Tetsuro Marunouchi, Kouichi Tanonaka

Biological & pharmaceutical bulletin, 38(8) 1094-7, 2015 Peer-reviewedInvitedLead author
Effects of 2-Octynyladenosine (YT-146) on Mitochondrial Function in Ischemic/Reperfused Rat Hearts.

Jun Sasamori, Yohei Abe, Tetsuro Marunouchi, Yoichi Manome, Takehiro Uchibori, Kouichi Tanonaka

Biological & pharmaceutical bulletin, 38(12) 1946-53, 2015 Peer-reviewed
Protective effect of geranylgeranylacetone via enhanced induction of HSPB1 and HSPB8 in mitochondria of the failing heart following myocardial infarction in rats.

Tetsuro Marunouchi, Satomi Inomata, Atsushi Sanbe, Norio Takagi, Kouichi Tanonaka

European journal of pharmacology, 730 140-7, May 5, 2014 Peer-reviewedLead author
Simultaneous loss of phospholipase C delta 1 and phospholipase C delta 3 causes cardiomyocyte apoptosis and cardiomyopathy

Y. Nakamura, K. Kanemaru, R. Kojima, Y. Hashimoto, T. Marunouchi, N. Oka, T. Ogura, K. Tanonaka, K. Fukami

CELL DEATH & DISEASE, 5 e1215, May, 2014 Peer-reviewed
Phenotype of cardiomyopathy in cardiac-specific heat shock protein B8 K141N transgenic mouse.

Atsushi Sanbe, Tetsuro Marunouchi, Tsutomu Abe, Yu Tezuka, Mizuki Okada, Sayuri Aoki, Hideki Tsumura, Junji Yamauchi, Kouichi Tanonaka, Hideo Nishigori …

The Journal of biological chemistry, 288(13) 8910-21, Mar 29, 2013 Peer-reviewed
Possible involvement of phosphorylated heat-shock factor-1 in changes in heat shock protein 72 induction in the failing rat heart following myocardial infarction.

Tetsuro Marunouchi, Mao Murata, Norio Takagi, Kouichi Tanonaka

Biological & pharmaceutical bulletin, 36(8) 1332-40, 2013 Peer-reviewedLead author
Possible involvement of HSP90-HSF1 multichaperone complex in impairment of HSP72 induction in the failing heart following myocardial infarction in rats.

Tetsuro Marunouchi, Masato Araki, Mao Murata, Norio Takagi, Kouichi Tanonaka

Journal of pharmacological sciences, 123(4) 336-46, 2013 Peer-reviewedLead author
Changes in small heat shock proteins HSPB1, HSPB5 and HSPB8 in mitochondria of the failing heart following myocardial infarction in rats.

Tetsuro Marunouchi, Yohei Abe, Mao Murata, Satomi Inomata, Atsushi Sanbe, Norio Takagi, Kouichi Tanonaka

Biological & pharmaceutical bulletin, 36(4) 529-39, 2013 Peer-reviewedLead author

Misc.

心筋幹・前駆細胞の増殖および心筋への分化に及ぼすtanshinone VIの効果

矢野絵美, 丸ノ内徹郎, 猪越南実, 田野中浩一

日本薬学会年会要旨集, 142年会 27PO1-38, Mar, 2022
スタチン系薬物の心筋虚血/再灌流障害の増悪作用への心筋CoQ10含量変化の関与

並木俊輔, 喬立娜, 清水安佳音, 丸ノ内徹郎, 田野中浩一

日本薬学会年会要旨集, 142年会 27PO1-39S, Mar, 2022
駆出率が保持された心不全(HFpEF)モデルの作製と各種パラメーターの評価

高橋きらら, 喬立娜, 内田愛美, 並木俊輔, 丸ノ内徹郎, 田野中浩一

日本薬学会年会要旨集, 142年会 27PO1-42S, Mar, 2022
Effects of Tanshinone VI on the differentiation from cardiac stem cells into cardiomyocytes

Motoi Mayu, Ikoshi Minami, Yano Emi, Marunouchi Tetsuro, Tanonaka Kouichi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95 1-SS-40, 2022
Simvastatin attenuates cardiac remodeling via Hsp90 inhibition.

Uchida Manami, Marunouchi Tetsuro, Fujita Kyo, Yano Emi, Tanonaka Kouichi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95 1-SS-31, 2022
Hsp90 contributes to cardiac hypertrophy in the development of heart failure via regulating c-Raf.

Itoh Takumi, Marunouchi Tetsuro, Yano Emi, Tanonaka Kouichi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 94 3-P2-08, 2021
Tanshinone VI promotes the differentiation of cardiosphere-derived cells into cardiomyocytes.

Marunouchi Tetsuro, Ikoshi Minami, Yano Emi, Tanonaka Kouichi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 94 3-P2-15, 2021
Changes in HSPA9 in the failing heart and effects of ACE inhibitor administration

矢野絵美, 丸ノ内徹郎, 鈴木智子, 鈴木千春, 田野中浩一

日本薬学会年会要旨集(Web), 141st 28P01-149, 2021
Changes in expression levels of Acot2 in the failing heart following cardiac pressure overload in mouse

中島みゆ貴, 丸ノ内徹郎, 大友隆之, 山田純司, 田野中浩一

日本薬学会年会要旨集(Web), 141st 28P01-148S, 2021
心筋リモデリングでのHsp90の役割の解明と新規治療法への応用

丸ノ内徹郎

生体機能と創薬シンポジウム要旨集, 2021, 2021
Changes in HSPA9 in the failing heart following myocardial infarction

Yano Emi, Marunouchi Tetsuro, Suzuki Satoko, Suzuki Chiharu, Tanonaka Kouichi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 93 2-P-206, 2020
Comparison of transplantation effects of cardiac progenitor cell types on the mitochondrial energy-producing ability after myocardial infarction in rats

Saotome Yuiki, Marunouchi Tetsuro, Yano Emi, Tanonaka Kouichi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 93 2-P-208, 2020
Roles of Hsp90 on cardiac remodeling in the development of chronic heart failure.

Abe Yumi, Marunouchi Tetsuro, Yano Emi, Tanonaka Kouichi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 93 1-SS-31, 2020
Possible involvement of necroptosis in the development of heart failure in mice.

丸ノ内徹郎, 矢野絵美, 田野中浩一

日本薬学会年会要旨集(CD-ROM), 140th 27Q-pm046, 2020
Involvement of RanBPM in HDAC6-mediated regulation of microtubule stability after myocardial infarction in rats

Nagata Shiho, Marunouchi Tetsuro, Tanonaka Kouichi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 92 1-P-053, 2019
Involvement of heat shock protein 90 in cardiac fibrosis

Tamura Shoko, Marunouchi Tetsuro, Tanonaka Kouichi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 92 3-P-065, 2019
Comparison of transplantation effects among cardiac progenitor cell types on the mitochondrial energy-producing ability after myocardial infarction in rats

Marunouchi Tetsuro, Yano Emi, Tanonaka Kouichi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 92 1-P-054, 2019
ラット心筋梗塞後不全心でのHSPA9の役割の解明

矢野絵美, 丸ノ内徹郎, 鈴木智子, 鈴木千春, 田野中浩一

日本薬学会年会要旨集(CD-ROM), 139th(3) 134-134, 2019
心筋梗塞ラットのミトコンドリア酸素消費速度に及ぼす心筋前駆細胞移植効果の比較

丸ノ内徹郎, 佐々木恭平, 田野中浩一

日本薬学会年会要旨集(CD-ROM), 139th(3) 137-137, 2019
心筋梗塞後不全心のHSPA9の病態生理学的変化

矢野絵美, 丸ノ内徹郎, 鈴木智子, 鈴木千春, 田野中浩一

日本薬理学雑誌, 154(Supplement), 2019

Books and Other Publications

薬系薬理学書 = Pharmacology for pharmacy

立川, 英一, 田野中, 浩一, 弘瀬, 雅教 (Role: Joint author, 循環器系薬理)

南江堂, Jul, 2018 (ISBN: 9784524403295)

Professional Memberships

Research Projects

Development of a Novel Chronic Heart Failure Therapy Focusing on Regulation of Hsp90-Client Interaction

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
心不全心での HSP90AA1 の役割の解明と新規治療法の開発

若手研究, 科研費, Apr, 2019 - Mar, 2022

丸ノ内徹郎
Therapeutic systems of muscular dystrophy by morpholino oligonucleotide-loaded nanobubble and ultrasound

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014

NEGISHI yoichi, MARUYAMA Kazuo, TAKAGI Norio, ARAMAKI Yukihiko, TAKAHASHI Yoko, NOMIZU Motoyoshi, TANONAKA Kouichi, MARUNOUCHI Tetsuro, KATAGIRI Fumihiko, OMATA Daiki, HAMANO Nobuhito, ISHII Yuko, OGURI Yukiko, SHIONO Hitomi, AKIYAMA Saki, MAYAMA Sayaka, KIKUCHI Taiki

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Awards

Papers

Misc.

Books and Other Publications

Professional Memberships

Research Projects

Menu

Coauthors