2018年10月
Fibroblast growth factor-2 inhibits CD40-mediated periodontal inflammation.
Journal of cellular physiology
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- 巻
- 234
- 号
- 5
- 開始ページ
- 7149
- 終了ページ
- 7160
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/jcp.27469
© 2018 Wiley Periodicals, Inc. Fibroblast growth factor-2 (FGF-2) stimulates periodontal regeneration by a broad spectrum of effects on periodontal ligament (PDL) cells, such as proliferation, migration, and production of extracellular matrix. A critical factor in the success of periodontal regeneration is the rapid resolution of inflammatory responses in the tissue. We explored an anti-inflammatory effect of FGF-2 during periodontal regeneration and healing. We found that FGF-2 on mouse periodontal ligament cells (MPDL22) markedly downregulated CD40 expression, a key player of inflammation. In addition, FGF-2 inhibited CD40 signaling by the non-canonical nuclear factor-kappa B2 (NFκB2) pathway, resulting in decreased production of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), which have the potential to recruit immune cells to inflamed sites. Furthermore, in vivo treatment of FGF-2 enhanced healing of skin wounds by counteracting the CD40-mediated inflammation. These results reveal that FGF-2 has an important function as a negative regulator of inflammation during periodontal regeneration and healing.
- リンク情報
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- DOI
- https://doi.org/10.1002/jcp.27469
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/30370560
- URL
- http://europepmc.org/abstract/med/30370560
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055697586&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85055697586&origin=inward
- ID情報
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- DOI : 10.1002/jcp.27469
- ISSN : 0021-9541
- eISSN : 1097-4652
- ORCIDのPut Code : 74198142
- PubMed ID : 30370560
- SCOPUS ID : 85055697586