論文

査読有り
2017年5月

Antimicrobial peptides extend lifespan in Drosophila

PLOS ONE
  • Gerrit Loch
  • ,
  • Ingo Zinke
  • ,
  • Tetsushi Mori
  • ,
  • Pilar Carrera
  • ,
  • Jonas Schroer
  • ,
  • Haruko Takeyama
  • ,
  • Michael Hoch

12
5
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.0176689
出版者・発行元
PUBLIC LIBRARY SCIENCE

Antimicrobial peptides (AMPs) are important defense molecules of the innate immune system. High levels of AMPs are induced in response to infections to fight pathogens, whereas moderate levels induced by metabolic stress are thought to shape commensal microbial communities at barrier tissues. We expressed single AMPs in adult flies either ubiquitously or in the gut by using the inducible GeneSwitch system to tightly regulate AMP expression. We found that activation of single AMPs, including Drosocin, resulted in a significant extension of Drosophila lifespan. These animals showed reduced activity of immune pathways over lifetime, less intestinal regenerative processes, reduced stress response and a delayed loss of gut barrier integrity. Furthermore, intestinal Drosocin induction protected the animals against infections with the natural Drosophila pathogen Pseudomonas entomophila, whereas a germ-reduced environment prevented the lifespan extending effect of Drosocin. Our study provides new insights into the crosstalk of innate immunity, intestinal homeostasis and ageing.

リンク情報
DOI
https://doi.org/10.1371/journal.pone.0176689
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000401487700027&DestApp=WOS_CPL
ID情報
  • DOI : 10.1371/journal.pone.0176689
  • ISSN : 1932-6203
  • Web of Science ID : WOS:000401487700027

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