Tomoiku Takaku

Profile Information

Affiliation: 准教授 (M.D, Ph.D), 血液内科学, 順天堂大学大学院医学研究科

J-GLOBAL ID: 201801001658594731
researchmap Member ID: B000332289

Research Interests

Research Areas

Research History

Oct, 2007 - Sep, 2010

Post doctal fellow, National Heart Lung and Blood institute, National Insitutes of Health

Committee Memberships

Oct, 2019 - Present

Executive Committee of TFR, Japanese Society of Hematology
Oct, 2018 - Present

Program committee member, Japanese Society of Hematology
Sep, 2018 - Present

評議員, 日本血液学会

Awards

2012

Orloff Award, National Institutes of Health

Tomoiku Takaku
Jun, 2008

Hippocrates, Tokyo Medical University

Tomoiku Takaku
2006

Sasa Memorial Award, Tokyo Medical University

Tomoiku Takaku

Papers

Case report: Ensitrelvir for treatment of persistent COVID-19 in lymphoma patients: a report of two cases.

Chiho Furuya, Hajime Yasuda, Makoto Hiki, Shuichi Shirane, Tomohito Yamana, Ayana Uchimura, Tadaaki Inano, Tomoiku Takaku, Yasuharu Hamano, Miki Ando

Frontiers in immunology, 15 1287300-1287300, 2024
Clinical management of second-generation tyrosine kinase inhibitor therapy in patients with newly diagnosed chronic myeloid leukemia in the chronic phase, focusing on age and dose effects

Michihide Tokuhira, Yuta Kimura, Takayuki Tabayashi, Naoki Watanabe, Shun Tsuchiya, Tomoiku Takaku, Noriyoshi Iriyama, Eriko Sato, Tomonori Nakazato, Toru Mitsumori …

International Journal of Hematology, May 2, 2023
Evaluation of bone marrow aspirates using the automated hematology analyzer Sysmex XN-3000.

Koji Tsuchiya, Konobu Kimura, Tomohiko Ai, Takamasa Yamamoto, Kaori Nagasaka, Hiroyuki Takemura, Yoko Edahiro, Kaori Saito, Yuki Horiuchi, Shigeki Misawa …

International journal of laboratory hematology, 45(4) 460-468, Mar 12, 2023
Endothelial function measured by peripheral arterial tonometry in patients with chronic myeloid leukemia on tyrosine kinase inhibitor therapy: a pilot study.

Tomohiro Kaneko, Sakiko Miyazaki, Azusa Kurita, Ryoko Morimoto, Shun Tsuchiya, Naoki Watanabe, Tomoiku Takaku, Norio Komatsu, Tohru Minamino

Cardio-oncology (London, England), 9(1) 11-11, Feb 22, 2023
Management and Risk Factors for Pleural Effusion in Japanese Patients with Chronic Myeloid Leukemia Treated with First-line Dasatinib in Real-world Clinical Practice

Shun Tsuchiya, Tomoiku Takaku, Naoki Watanabe, Noriyoshi Iriyama, Yuta Kimura, Eisaku Iwanaga, Kei-ji Sugimoto, Toru Mitsumori, Maho Ishikawa, Tomonori Nakazato …

Internal Medicine, 2023
Outcomes of adolescents and young adults with chronic-phase chronic myeloid leukaemia treated with tyrosine kinase inhibitors

Yuriko Nishiyama-Fujita, Tomonori Nakazato, Noriyoshi Iriyama, Michihide Tokuhira, Maho Ishikawa, Eriko Sato, Tomoiku Takaku, Keiji Sugimoto, Hiroyuki Fujita, Isao Fujioka …

Annals of Medicine, 54(1) 1244-1254, Dec 31, 2022
Bosutinib-induced late-onset severe liver injury preceded by eosinophilia.

Naoki Watanabe, Tomoiku Takaku, Isao Fujioka, Shun Tsuchiya, Miki Ando

Annals of hematology, 101(10) 2257-2262, Oct, 2022
A pilot study examining the efficacy of hochuekkito for improving quality of life in patients with myeloproliferative neoplasms.

Yoko Edahiro, Michiaki Koike, Shuko Nojiri, Yoshinao Harada, Akihiko Gotoh, Kazutoshi Fujibayashi, Yuji Nishizaki, Naotake Yanagisawa, Tomoiku Takaku, Hideaki Nitta …

Japanese journal of clinical oncology, 52(8) 872-878, May 14, 2022
Hodgkin Lymphoma on Hemodialysis Successfully Treated with Extended Courses of Brentuximab Vedotin

Ayana Uchimura, Hajime Yasuda, Jun Ando, Yasunori Ota, Makoto Sasaki, Tomoiku Takaku, Yutaka Tsukune, Miyuki Tsutsui, Yoko Edahiro, Naoki Watanabe …

Case Reports in Oncology, 15(1) 263-266, Mar 15, 2022
Bosutinib-induced lung injury: a report of two cases and literature review.

Naoki Watanabe, Tomoiku Takaku, Yutaka Tsukune, Hajime Yasuda, Tomonori Ochiai, Kohei Yamada, Hiroki Nakazawa, Saori Hotta, Takayasu Nishimaki, Haruhi Takagi …

International journal of hematology, 115(6) 902-905, Feb 28, 2022
Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors.

Yosuke Tanaka, Reina Takeda, Tsuyoshi Fukushima, Keiko Mikami, Shun Tsuchiya, Moe Tamura, Keito Adachi, Terumasa Umemoto, Shuhei Asada, Naoki Watanabe …

Nature communications, 13(1) 271-271, Jan 12, 2022
[Systemic chemotherapy combined with thrombopoietin receptor agonist for the treatment of diffuse large B-cell lymphoma complicated with aplastic anemia].

Yasutaka Fukuda, Yoko Edahiro, Tomoiku Takaku, Chiho Furuya, Shuichi Shirane, Yasuharu Hamano, Michiaki Koike, Norio Komatsu

[Rinsho ketsueki] The Japanese journal of clinical hematology, 63(1) 20-25, 2022
Intravascular large B-cell lymphoma as a recurrence of primary central nervous system lymphoma after chemotherapy: A case report.

Yoko Edahiro, Tomoiku Takaku, Mario Suzuki, Yasutaka Fukuda, Sakiko Harada, Shintaro Kinoshita, Tadaaki Inano, Shuichi Shirane, Yasuharu Hamano, Akihide Kondo …

Leukemia research reports, 15 100249-100249, 2021
Expansion of senescent megakaryocyte-lineage cells maintains CML cell leukemogenesis.

Yamato Tanabe, Shimpei Kawamoto, Tomoiku Takaku, Soji Morishita, Atsushi Hirao, Norio Komatsu, Eiji Hara, Naofumi Mukaida, Tomohisa Baba

Blood advances, 4(24) 6175-6188, Dec 22, 2020
The EUTOS long-term survival score predicts disease-specific mortality and molecular responses among patients with chronic myeloid leukemia in a practice-based cohort.

Eriko Sato, Noriyoshi Iriyama, Michihide Tokuhira, Tomoiku Takaku, Maho Ishikawa, Tomonori Nakazato, Kei-Ji Sugimoto, Hiroyuki Fujita, Yuta Kimura, Isao Fujioka …

Cancer medicine, 9(23) 8931-8939, Dec, 2020
Platelet-rich plasma (PRP) accelerates murine patellar tendon healing through enhancement of angiogenesis and collagen synthesis.

Yohei Kobayashi, Yoshitomo Saita, Tomoiku Takaku, Tomomasa Yokomizo, Hirofumi Nishio, Hiroshi Ikeda, Yuji Takazawa, Masashi Nagao, Kazuo Kaneko, Norio Komatsu

Journal of experimental orthopaedics, 7(1) 49-49, Jul 8, 2020 Peer-reviewed
Platelet-rich plasma promotes recruitment of macrophages in the process of tendon healing.

Hirofumi Nishio, Yoshitomo Saita, Yohei Kobayashi, Tomoiku Takaku, Shin Fukusato, Sayuri Uchino, Takanori Wakayama, Hiroshi Ikeda, Kazuo Kaneko

Regenerative therapy, 14 262-270, Jun, 2020 Peer-reviewed
Nilotinib treatment induced large granular lymphocyte expansion and maintenance of longitudinal remission in a Philadelphia chromosome-positive acute lymphoblastic leukemia.

Masao Hagihara, Jian Hua, Morihiro Inoue, Tomoyuki Uchida, Shiro Ide, Shin Ohara, Tomoiku Takaku

International journal of hematology, 111(5) 719-723, May, 2020
[Management of vascular adverse events during tyrosine kinase inhibitors in patients with chronic myeloid leukemia].

Tomoiku Takaku

[Rinsho ketsueki] The Japanese journal of clinical hematology, 61(9) 1018-1027, 2020
Potential role for second‑generation tyrosine kinase inhibitors in patients with chronic myeloid leukemia harboring additional clonal chromosome abnormalities: A retrospective CML Cooperative Study Group analysis.

Maho Ishikawa, Noriyoshi Iriyama, Michihide Tokuhira, Tomoiku Takaku, Eriko Sato, Kei-Ji Sugimoto, Tomonori Nakazato, Hiroyuki Fujita, Yuta Kimura, Isao Fujioka …

Oncology reports, 42(6) 2836-2843, Dec, 2019 Peer-reviewed

Misc.

慢性骨髄性白血病患者のTKI治療における血栓症に関する多施設共同後方視的解析中間解析アップデート(An updated analysis of vascular adverse events in large cohort of TKI treated Japanese CML patients)

高久智生, 藤岡功, 入山規良, 得平道英, 木村勇太, 岩永栄作, 佐藤恵理子, 石川真穂, 仲里朝周, 杉元啓二 …

臨床血液, 59(9) 1705-1705, Sep, 2018
マウス胎生期における造血幹細胞の成熟はEvi-1/Hlf軸によって制御される(Evi-1/Hlf axis regulates HSC maturation in the mouse embryo)

横溝智雅, 渡邊直紀, 梅本晃正, 高久智生, 須田年生, 黒川峰夫, 小松則夫, 大里元美

臨床血液, 59(9) 1571-1571, Sep, 2018
CML付加的染色体異常と予後に関する後方視的解析(Additional chromosomal abnormalities at diagnosis and their impact on treatment response in CML)

石川真穂, 入山規良, 得平道英, 高久智生, 佐藤恵理子, 杉元啓二, 仲里朝周, 岩永栄作, 藤田浩之, 木村勇太 …

臨床血液, 59(9) 1561-1561, Sep, 2018
ニロチニブ治療患者における心血管系有害事象リスク因子に関する多施設共同後方視的研究(Analysis of cardiovascular risk factors in nilotinib-treated Japanese CML patients)

藤岡功, 高久智生, 得平道英, 木村勇太, 岩永栄作, 杉元啓二, 仲里朝周, 入山規良, 佐藤恵理子, 石川真穂 …

臨床血液, 59(9) 1561-1561, Sep, 2018
【診断と治療のABC[133]悪性リンパ腫】 (第2章)病理・病態生理病態生理

新田英昭, 高久智生

最新医学, 別冊(悪性リンパ腫) 35-42, Apr, 2018
MAIDI-TOF MSデータを用いたバンコマイシン低感受性MRSA株の自動判別

朝倉弘太, 片山由紀, 松井秀仁, 高田徹, 花木秀明, 柴山恵吾, 矢原耕史, 高久智生, 落合友則, 小松則夫 …

日本臨床微生物学雑誌, 28(Suppl.1) 441-441, Dec, 2017
慢性骨髄性白血病治療の現状

高久智生

東京内科医会会誌, 33(2) 156-163, Dec, 2017
単一施設におけるdasatinib投与中に肺高血圧症を合併した慢性骨髄性白血病症例の後方視的検討

枝廣陽子, 高久智生, 小西博応, 築根豊, 藤岡功, 高須清, 後藤明彦, 代田浩之, 小松則夫

臨床血液, 58(11) 2213-2218, Nov, 2017
慢性骨髄性白血病に対するイマチニブ中止試験

高久智生

Medical Practice, 34(9) 1552-1554, Sep, 2017
多血小板血漿(PRP)はマクロファージの遊走を介して腱の組織修復を促進する

西尾啓史, 齋田良知, 小林洋平, 高久智生, 金子和夫

日本整形外科学会雑誌, 91(8) S1571-S1571, Aug, 2017
器質化肺炎の急性増悪を合併し突然死に至ったsarcoidosis-lymphoma syndrome

飯塚和秀, 安藤純, 増田安土, 落合友則, 友政蘭, 安田肇, 高久智生, 大田泰徳, 八尾隆史, 後藤明彦 …

臨床血液, 58(8) 927-932, Aug, 2017
Eprobe-PCR法を用いた簡便・高感度な造血器腫瘍遺伝子定量検査キットの開発と精度検証

土屋浩二, 森下総司, 高久智生, 臼井健悟, 大川貴裕, 由利麻衣子, 三澤成毅, 山中康成, 田部陽子, 大坂顯通

日本臨床検査自動化学会会誌, 42(4) 424-424, Aug, 2017
ANALYSIS OF VASCULAR ADVERSE EVENTS IN TKI TREATED JAPANESE CML PATIENTS: RETROSPECTIVE LARGE COHORT STUDY OF CML COOPERATIVE STUDY GROUP

I. Fujioka, T. Takaku, N. Iriyama, M. Tokuhira, E. Sato, M. Ishikawa, T. Nakazato, K-J. Sugimoto, H. Fujita, N. Asou …

HAEMATOLOGICA, 102 435-436, Jun, 2017
Dasatinib少量間歇投与で7年間血液学的寛解を維持している超高齢者慢性骨髄性白血病

奥田優子, 青田泰雄, 横山智央, 北川尚之, 高久智生, 後藤明彦, 小松則夫

老年者造血器疾患研究会会誌, 25 18-20, Jun, 2017
血小板輸血によるアナフィラキシーを契機に診断された先天性ハプトグロビン欠損症

安藤純, 増田安土, 飯塚和秀, 落合友則, 高久智生, 大澤俊也, 嶋田英子, 渡辺嘉久, 小松則夫, 大坂顯通

臨床血液, 57(12) 2507-2511, Dec, 2016
便潜血検査でdasatinibによる薬剤性腸炎の早期診断が可能であった慢性骨髄性白血病の3例

藤岡功, 高久智生, 渡邊直紀, 後藤明彦, 小松則夫

臨床血液, 57(6) 780-780, Jun, 2016
併発した免疫性血小板減少症にエルトロンボパグを投与しR-CHOP療法の導入が可能であったDLBCL

奥田優子, 青田泰雄, 羽生直史, 横山智央, 北川尚之, 高久智生, 後藤明彦, 小松則夫

老年者造血器疾患研究会会誌, 24 20-23, Jun, 2016
Dasatinib少量間歇投与で7年間血液学的寛解を維持している超高齢者慢性骨髄性白血病

奥田優子, 青田泰雄, 横山智央, 北川尚之, 高久智生, 後藤明彦, 小松則夫

老年者造血器疾患研究会会誌, 24 4-4, Jun, 2016
Eltrombopagによる治療中に骨髄線維症を生じた特発性血小板減少性紫斑病

堀越昶, 津久田純平, 安部涼平, 藤原直樹, 伊藤栄作, 高久智生

臨床血液, 57(5) 638-641, May, 2016
慢性骨髄性白血病の微小残存病変高感度検出にむけたBCR/ABLゲノムDNA定量技術の構築

上田雄也, 森下総司, 高久智生, 佐藤恵理子, 大坂顯通, 常田聡, 小松則夫

日本分子生物学会年会プログラム・要旨集(Web), 39th ROMBUNNO.1P‐0841 (WEB ONLY), 2016

Professional Memberships

Research Projects

TKI治療抵抗性の慢性骨髄性白血病細胞に対する新規治療戦略の開発

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

高久智生
Analysis of hematopoietic regulation system by circadian rhythm

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2015

TOMOIKU Takaku
Development of the new treatment strategy of ATRA-resistant APL using PP2A-FOXO3A activation pathway

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

KOMATSU NORIO, TAKAKU Tomoiku
Applications of molecular nanotechnology for human disease using DNA-encode based gene expression analysis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2005 - 2007

OHYASHIKI Junko, YAMADA Seiko, OHYASHIKI Junko

Industrial Property Rights

特開2007-159416 ダサチニブの耐性の判別とその克服方法

田内哲三, 布田晃介, 高久智生, 指田吾郎, 住昌彦, 岡部聖一, 大屋敷純子, 大屋敷一馬

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