© 2016 The Author(s). We report precursory seismic patterns prior to the 2016 Kumamoto earthquakes, as measured by four different methods based on changes in seismicity that can be used for earthquake forecasting: the b-value method, two methods of seismic quiescence evaluation, and an analysis of seismicity density in space and time. The spatial extent of precursory patterns differs from one method to the other and ranges from local scales (typically, asperity size) to regional scales (e.g., 2° × 3° around the source zone). The earthquakes were preceded by periods of pronounced anomalies, which lasted in yearly scales (1.5 years), or longer (>3 years). We demonstrate that a combination of multiple methods detected different signals prior to the Kumamoto earthquakes. This indicates great potential to reduce the hazard at possible future sites of earthquakes relative to long-term seismic hazard assessment. We also found that the seismic quiescence in a regional-scale area, detected by using the two methods of seismic quiescence evaluation, was a common precursor to the 2016 Kumamoto earthquakes and 2015 Off Satsuma Peninsula earthquake. The result allows us to interpret both events as the onset that occurred at a section along the tectonic line from the Okinawa Trough through the Beppu-Shimabara graben.