Toshiyuki Ko

Profile Information

Affiliation: Assistant Professor, Department of Frontier Cardiovascular Science, Graduate School of Medicine, The University of Tokyo
: Project researcher, Sakakibara Heart Institute

J-GLOBAL ID: 202101008079893808
researchmap Member ID: R000031417

Research Interests

Research Areas

Life sciences / Cardiology / Heart failure

Research History

Apr, 2020 - Present

Project Assistant Professor, Graduate School of Medicine, Department of Cardiovascular Medicine, The University of Tokyo
Apr, 2019 - Mar, 2020

Project researcher, Graduate School of Medicine, Department of Cardiovascular Medicine, The University of Tokyo
Apr, 2017 - Mar, 2019

Research Fellowship for Young Scientists, Japan Society for the Promotion of Science
Apr, 2014 - Mar, 2018

Graduate School of Medicine Doctoral Program, Cardiovascular Medicine, The University of Tokyo
Apr, 2012 - Mar, 2014

Department of Cardiology, Sakakibara Heart Institute
Apr, 2010 - Mar, 2012

St. Luke’s international hospital

Education

Apr, 2014 - Mar, 2018

Graduate School of Medicine Doctoral Program, Cardiovascular Medicine, The University of Tokyo
Apr, 2006 - Mar, 2010

Faculty of Medicine, The University of Tokyo
Apr, 2004 - Mar, 2006

The University of Tokyo
Apr, 2001 - Mar, 2004

東京都立戸山高等学校

Awards

Papers

Myocardial DNA Damage Predicts Heart Failure Outcome in Various Underlying Diseases.

Zhehao Dai, Toshiyuki Ko, Kanna Fujita, Seitaro Nomura, Yukari Uemura, Kenji Onoue, Momoko Hamano, Manami Katoh, Shintaro Yamada, Mikako Katagiri …

JACC. Heart failure, 12(4) 648-661, Apr, 2024 Peer-reviewedLead author
Applying the HARMS2-AF Risk Score for Japanese population: An analysis of a nationwide epidemiological dataset.

Toshiyuki Ko, Yuta Suzuki, Hidehiro Kaneko, Takahiro Jimba, Jin Komuro, Akira Okada, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Koichi Node …

European journal of preventive cardiology, Mar 19, 2024 Peer-reviewedLead author
A Valuable Genetically Engineered Nonhuman Primate Model of Dilated Cardiomyopathy.

Toshiyuki Ko, Issei Komuro

JACC. Basic to translational science, 9(3) 396-398, Mar, 2024 Lead author
A Pathogenic LAMP2 Non-Canonical Splice Site Mutation Caused Danon Disease Requiring Heart Transplantation.

Ryo Abe, Toshiyuki Ko, Shunsuke Inoue, Seitaro Nomura, Takahiro Jimba, Manami Katoh, Masamichi Ito, Junichi Ishida, Eisuke Amiya, Norifumi Takeda …

Circulation journal : official journal of the Japanese Circulation Society, Jan 20, 2024 Peer-reviewed
Network-based identification of diagnosis-specific trans-omic biomarkers via integration of multiple omics data

Md Mamunur Rashid, Momoko Hamano, Midori Iida, Michio Iwata, Toshiyuki Ko, Seitaro Nomura, Issei Komuro, Yoshihiro Yamanishi

Biosystems, 105122-105122, Jan, 2024 Peer-reviewed
Compound Heterozygous Truncating Variants in the BAG5 Gene As a Cause of Early-Onset Dilated Cardiomyopathy

Shunsuke Inoue, Toshiyuki Ko, Seitaro Nomura, Takanobu Yamada, Bo Zhang, Zhehao Dai, Takahiro Jimba, Manami Kato, Junichi Ishida, Eisuke Amiya …

Circulation: Genomic and Precision Medicine, Oct 24, 2023 Peer-reviewed
Alpha 7 nicotinic acetylcholine receptors signaling boosts cell-cell interactions in macrophages effecting anti-inflammatory and organ protection.

Yasuna Nakamura, Hirotaka Matsumoto, Chia-Hsien Wu, Daichi Fukaya, Rie Uni, Yosuke Hirakawa, Mikako Katagiri, Shintaro Yamada, Toshiyuki Ko, Seitaro Nomura …

Communications biology, 6(1) 666-666, Jun 23, 2023 Peer-reviewed
Recent Advances in Translational Research for Heart Failure in Japan

SHINTARO YAMADA, TOSHIYUKI KO, MIKAKO KATAGIRI, HIROYUKI MORITA, ISSEI KOMURO

Journal of Cardiac Failure, 29(6) 931-938, Jun, 2023 Peer-reviewedLead author
TEAD1 trapping by the Q353R–Lamin A/C causes dilated cardiomyopathy

Shintaro Yamada, Toshiyuki Ko, Masamichi Ito, Tatsuro Sassa, Seitaro Nomura, Hiromichi Okuma, Mayuko Sato, Tsuyoshi Imasaki, Satoshi Kikkawa, Bo Zhang …

Science Advances, 9(15), Apr 14, 2023 Peer-reviewedLead author
LMNA Mutations and Right Heart Failure in Cardiomyopathy Patients With Left Ventricular Assist Devices

Takanobu Yamada, Seitaro Nomura, Eisuke Amiya, Manami Katoh, Shunsuke Inoue, Satoshi Hatsuse, Kanna Fujita, Masamichi Ito, Takanori Fujita, Chie Bujo …

Journal of Cardiac Failure, 29(5) 855-857, Mar, 2023 Peer-reviewed
心筋組織におけるDNA損傷は原疾患によらず左室駆出率の低下した心不全の治療反応及び予後を予測する

戴哲皓, 候聡志, 野村征太郎, 藤田寛奈, 濱野桃子, 山西芳裕, 尾上健児, 小室一成

日本内科学会雑誌, 112(臨増) 144-144, Feb, 2023
Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction

Shintaro Yamada, Toshiyuki Ko, Satoshi Hatsuse, Seitaro Nomura, Bo Zhang, Zhehao Dai, Shunsuke Inoue, Masayuki Kubota, Kosuke Sawami, Takanobu Yamada …

Nature Cardiovascular Research, 1(11) 1072-1083, Nov 17, 2022 Peer-reviewedLead author
Heart Failure Pathogenesis Elucidation and New Treatment Method Development.

Mikako Katagiri, Shintaro Yamada, Manami Katoh, Toshiyuki Ko, Masamichi Ito, Issei Komuro

JMA journal, 5(4) 399-406, Oct 17, 2022
Molecular Genomic Autopsy ― Clues to Preventing Further Tragedy? ―

Toshiyuki Ko, Hiroyuki Morita

Circulation Journal, Sep 17, 2022 Peer-reviewedInvitedLead authorCorresponding author
Takotsubo Cardiomyopathy and Peripartum Cardiomyopathy: Similar in Features, but Different in Nature

Toshiyuki Ko, Hiroyuki Morita

International Heart Journal, 63(4) 651-653, Jul 30, 2022 Peer-reviewedInvitedLead authorCorresponding author
Manipulating Cardiomyocyte Plasticity for Heart Regeneration

Toshiyuki Ko, Seitaro Nomura

Frontiers in Cell and Developmental Biology, 10 929256, Jul 11, 2022 Peer-reviewedLead author
Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis

Toshiyuki Ko, Seitaro Nomura, Shintaro Yamada, Kanna Fujita, Takanori Fujita, Masahiro Satoh, Chio Oka, Manami Katoh, Masamichi Ito, Mikako Katagiri …

Nature Communications, 13(1) 3275-3275, Jun, 2022 Peer-reviewedLead author
シングルセル分子病理解析による心臓サルコイドーシスの病態解明とバイオマーカーの同定

片桐美香子, 伊藤正道, 候聡志, 山田臣太郎, 野村征太郎, 小室一成

日本内分泌学会雑誌, 97(5) 1476-1476, Mar, 2022
心筋細胞のβアレスチン偏向性受容体CXCR7は心筋梗塞後リモデリングを抑制する

石塚理人, 原田睦生, 野村征太郎, 候聡志, 武城怜史, 郭嘉煕, てき博文, 岸川理紗, 東口治弘, 小室一成

日本内分泌学会雑誌, 97(5) 1476-1476, Mar, 2022
シングルセル分子病理解析による心臓サルコイドーシスの病態解明とバイオマーカーの同定

片桐美香子, 伊藤正道, 候聡志, 山田臣太郎, 野村征太郎, 小室一成

日本内分泌学会雑誌, 97(5) 1476-1476, Mar, 2022

Misc.

慢性心不全患者と便秘

高圓恵理, 候聡志, 伊東紀揮, 上村夕香理, 岡山大, 田中宏和, 弓野大

日本在宅医学会大会, 20回 182-182, Apr, 2018
心不全と排便の関係

高圓恵理, 候聡志, 伊東紀揮, 岡山大, 藤田真奈, 諸冨伸夫, 臼井靖博, 田中宏和, 上村夕香理, 弓野大

日本循環器学会学術集会抄録集, 81回 CA-06, Mar, 2017

Books and Other Publications

「循環器専門医」2021年8月号「シングルセル解析に基づく循環器病態研究」

(Role: Contributor)

南江堂, 2021
臨床雑誌「内科」128巻1号「特集：心不全のすべて〜増え続ける心不全患者にどう対峙するか〜」

(Role: Contributor)

南江堂, 2021
「Heart View」2020年10月号「循環器疾患バイオマーカー有用性と可能性」

(Role: Contributor)

メジカルビュー社, 2020
日経メディカル 2018年5月号「あなたが防ぐ急性憎悪」

(Role: Contributor)

日経BP社, 2018
末梢血管疾患診療マニュアル

(Role: Contributor)

南江堂, 2018
研修医・若手Drにエキスパートが伝授する循環器診療のロジック

(Role: Contributor)

南山堂, 2017
在宅新療0-100 2017年5月号「非専門医でもわかる心不全の在宅医療のコツ」

(Role: Contributor)

へるす出版, 2017
循環器内科ポケットバイブル

(Role: Joint editor)

中山書店, 2015

Professional Memberships

Research Projects

非分裂細胞である心筋細胞のDNA損傷と老化による心不全発症機序の解明

科学研究費助成事業基盤研究(A), 基盤研究(A), 日本学術振興会, Apr, 2021 - Mar, 2024

小室一成, 野村征太郎, 候聡志, 加藤愛巳
Single-cell pathological dynamics in tissue repair and remodeling after myocardial infarction

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Ko Toshiyuki
一細胞解析に基づく心不全における非心筋細胞の再定義及びその機能解明

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, Apr, 2017 - Mar, 2019

候聡志
The effect of high-fat low-carbon diet on cardiac function and metabolism

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Toko Haruhiro, HARADA Mutsuo, KO Toshiyuki, MURAKAMI Haruka, ISHIZUKA Masato

Profile Information

Research Interests

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Research History

Education

Awards

Papers

Misc.

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